Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. (Q34380191)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24158909%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24158909%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

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3

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28 February 2020

Mitali A Tambe

4

1 reference

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28 February 2020

Hari B Kamadurai

7

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28 February 2020

Hari B Kamadurai

8

1 reference

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28 February 2020

Alexander Lancaster

10

1 reference

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28 February 2020

14

Stephen L Buchwald

1 reference

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28 February 2020

15

Susan Lindquist

1 reference

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28 February 2020

Kim A Caldwell

11

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Jean-Christophe Rochet

object named as

Jean-Christophe Rochet

13

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Guy A Caldwell

object named as

Guy A Caldwell

12

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author name string

Daniel F Tardiff

1

1 reference

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28 February 2020

Nathan T Jui

2

1 reference

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28 February 2020

Michelle L Thompson

5

1 reference

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28 February 2020

Chee Yeun Chung

6

1 reference

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28 February 2020

Hyoung Tae Kim

9

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28 February 2020

language of work or name

English

0 references

publication date

24 October 2013

1 reference

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28 February 2020

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28 February 2020

volume

342

1 reference

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28 February 2020

issue

6161

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28 February 2020

page(s)

979-983

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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

28 February 2020

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RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

6 July 2018

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Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context

6 July 2018

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Sna3 is an Rsp5 adaptor protein that relies on ubiquitination for its MVB sorting

6 July 2018

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Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms

6 July 2018

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Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

6 July 2018

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Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway

6 July 2018

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A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

6 July 2018

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VPS35 mutations in Parkinson disease

6 July 2018

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How were new medicines discovered?

6 July 2018

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Synaptic vesicle trafficking and Parkinson's disease

6 July 2018

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A yeast model of FUS/TLS-dependent cytotoxicity

6 July 2018

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

6 July 2018

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Structure and function of a HECT domain ubiquitin-binding site

6 July 2018

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Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease

6 July 2018

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The Parkinson disease protein α-synuclein inhibits autophagy

6 July 2018

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Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis

6 July 2018

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A survey of yeast genomic assays for drug and target discovery

6 July 2018

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Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

6 July 2018

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The ubiquitin code of yeast permease trafficking.

6 July 2018

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Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

6 July 2018

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6 July 2018

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Substrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells

6 July 2018

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6 July 2018

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6 July 2018

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alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

6 July 2018

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Biochemical and genetic analysis of the yeast proteome with a movable ORF collection

6 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

6 July 2018

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The basal turnover of yeast branched-chain amino acid permease Bap2p requires its C-terminal tail

6 July 2018

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6 July 2018

Basic culture methods

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Yeast cells provide insight into alpha-synuclein biology and pathobiology

6 July 2018

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Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

21 January 2018

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Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

21 January 2018

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SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

21 January 2018

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A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by α-synuclein

21 January 2018

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Impairment of microtubule system increases alpha-synuclein aggregation and toxicity

21 January 2018

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Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

21 January 2018

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Preparation of ubiquitinated substrates by the PY motif-insertion method for monitoring 26S proteasome activity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24158909

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24158909

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1245321

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24158909%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

0 references

1 reference

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28 February 2020

PubMed publication ID

24158909

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24158909%20AND%20SRC:MED&resulttype=core&format=json