Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development (Q37709373)

22 August 2017

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title

Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development (English)

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22 August 2017

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Evan R Barry

1

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22 August 2017

Gareth N Corry

series ordinal

2

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22 August 2017

Theodore P Rasmussen

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

1 April 2010

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Expert Opinion on Therapeutic Targets

22 August 2017

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22 August 2017

14

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22 August 2017

4

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22 August 2017

405-418

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The diverse functions of histone lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The structure of DNA in the nucleosome core

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Chromatin structure and epigenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Protein methyltransferases as a target class for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Chemical probes for histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

New nomenclature for chromatin-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Epigenetic regulation: methylation of histone and non-histone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

A histone H3 lysine 27 demethylase regulates animal posterior development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The molecular biology of mixed lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Dot1p modulates silencing in yeast by methylation of the nucleosome core

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Structural and sequence motifs of protein (histone) methylation enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The SET-domain protein superfamily: protein lysine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Histone modifications defining active genes persist after transcriptional and mitotic inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Overexpression of grappa encoding a histone methyltransferase enhances stress resistance in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Profile of histone lysine methylation across transcribed mammalian chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Misguided transcriptional elongation causes mixed lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The polycomb-group gene Ezh2 is required for early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Changes in H3K79 methylation during preimplantation development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The first molecular details of ALT in human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The epigenetic regulation of mammalian telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Mouse hematopoietic stem cells, unlike human and mouse embryonic stem cells, exhibit checkpoint-apoptosis coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The role of CALM-AF10 gene fusion in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The leukemogenic CALM/AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

U937 cell line has a t(10;11)(p13-14;q14-21) rather than a deletion of 11q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

A chromatin landmark and transcription initiation at most promoters in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Divergent transcription from active promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Developmental gonadal expression of the transcription factor SET and its target gene, P450c17 (17alpha-hydroxylase/c17,20 lyase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

Nuclear pore proteins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003623241

10.1517/14728221003623241

21 January 2018

Identifiers

DOI

1 reference

release_uxwp7dgtcjafti72emthwt5ae4

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uxwp7dgtcjafti72emthwt5ae4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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