Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy. (Q37714008)

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scientific article published on 29 January 2014

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English	Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.	scientific article published on 29 January 2014

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scholarly article

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6 March 2020

Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy (English)

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6 March 2020

Hepatitis C virus

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Brian H Johnston

7

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6 March 2020

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Anne Dallas

1

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6 March 2020

Heini Ilves

2

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6 March 2020

Han Ma

3

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6 March 2020

Daniel J Chin

4

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6 March 2020

Ian Maclachlan

5

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6 March 2020

Klaus Klumpp

6

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6 March 2020

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29 January 2014

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6 March 2020

Journal of Virology

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6 March 2020

88

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6 March 2020

9

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6 March 2020

4647-4656

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6 March 2020

Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers

1 reference

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23 August 2017

Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice

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23 August 2017

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

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23 August 2017

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

1 reference

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HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites

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Preliminary study of two antiviral agents for hepatitis C genotype 1.

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In vitro characterization of the activity of PF-05095808, a novel biological agent for hepatitis C virus therapy

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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

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Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1.

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Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity

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A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants

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Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity

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Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs

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23 August 2017

siRNA and innate immunity

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Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

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23 August 2017

Overcoming the innate immune response to small interfering RNA.

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23 August 2017

Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference

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23 August 2017

Cellular cofactors affecting hepatitis C virus infection and replication

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23 August 2017

Combinatorial RNAi: a winning strategy for the race against evolving targets?

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23 August 2017

Small Interfering RNA Targeted to Hepatitis C Virus 5' Nontranslated Region Exerts Potent Antiviral Effect

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23 August 2017

Silencing of hepatitis A virus infection by small interfering RNAs

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23 August 2017

Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region

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23 August 2017

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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23 August 2017

Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective

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23 August 2017

Genetic diversity and evolution of hepatitis C virus--15 years on

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23 August 2017

A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon

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23 August 2017

Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs

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23 August 2017

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

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23 August 2017

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

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23 August 2017

Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7

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23 August 2017

Core protein-coding sequence, but not core protein, modulates the efficiency of cap-independent translation directed by the internal ribosome entry site of hepatitis C virus

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23 August 2017

A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs

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23 August 2017

Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA.

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23 August 2017

Unique features of internal initiation of hepatitis C virus RNA translation

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23 August 2017

Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA

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23 August 2017

Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus

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23 August 2017

Biosynthesis and biochemical properties of the hepatitis C virus core protein

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23 August 2017

Sequence analysis of the core gene of 14 hepatitis C virus genotypes

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23 August 2017

Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes

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23 August 2017

Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution

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Liver as a target for oligonucleotide therapeutics

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Safety profile of RNAi nanomedicines

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Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052.

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New insights into the HCV quasispecies and compartmentalization

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Nomenclature and numbering of the hepatitis C virus

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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

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shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA.

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14 September 2017

Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model

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Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

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14 September 2017

Human immunodeficiency virus type 1 escape from RNA interference

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14 September 2017

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches

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HIV-1 Escape From RNAi Antivirals: Yet Another Houdini Action?

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A scalable, extrusion-free method for efficient liposomal encapsulation of plasmid DNA.

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Hepatitis C in the United States

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Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials

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1 September 2018

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice

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1 September 2018

Overcoming barriers to care for hepatitis C.

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1 September 2018

The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C.

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pH-triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo

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Inhibition of Hepatitis C IRES-Mediated Gene Expression by Small Hairpin RNAs in Human Hepatocytes and Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24478422

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/JVI.00105-14

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478422%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478422%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478422%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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