Engineered cystine-knot miniproteins for diagnostic applications (Q37724879)

22 August 2017

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title

Engineered cystine-knot miniproteins for diagnostic applications (English)

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22 August 2017

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Harald Kolmar

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22 August 2017

1 April 2010

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

22 August 2017

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22 August 2017

10

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22 August 2017

3

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22 August 2017

361-368

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NMR as a tool for elucidating the structures of circular and knotted proteins.

22 August 2017

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Knottin cyclization: impact on structure and dynamics

21 January 2018

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Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

21 January 2018

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Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects

21 January 2018

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Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.

21 January 2018

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The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery

21 January 2018

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The KNOTTIN website and database: a new information system dedicated to the knottin scaffold.

21 January 2018

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Protective effect of retinal ischemia by blockers of voltage-dependent calcium channels and intracellular calcium stores

21 January 2018

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SNX-111, a novel, presynaptic N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits.

21 January 2018

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Autoradiographic localization of N-type VGCCs in gerbil hippocampus and failure of omega-conotoxin MVIIA to attenuate neuronal injury after transient cerebral ischemia.

21 January 2018

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Squash inhibitors: from structural motifs to macrocyclic knottins

21 January 2018

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Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins

21 January 2018

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Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth

21 January 2018

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Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker

21 January 2018

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NMR structure of a minimized human agouti related protein prepared by total chemical synthesis

21 January 2018

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Current trends in the structure-activity relationship studies of the endogenous agouti-related protein (AGRP) melanocortin receptor antagonist

21 January 2018

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High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein

21 January 2018

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Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice

21 January 2018

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Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein

21 January 2018

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Sequence requirements of the GPNG beta-turn of the Ecballium elaterium trypsin inhibitor II explored by combinatorial library screening

21 January 2018

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Mast cell tryptase beta as a target in allergic inflammation: an evolving story

21 January 2018

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Head-to-tail cyclized cystine-knot peptides by a combined recombinant and chemical route of synthesis

21 January 2018

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Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta

21 January 2018

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Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

21 January 2018

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Identification of epitope-like consensus motifs using mRNA display

21 January 2018

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Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities

21 January 2018

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A fusion protein system for the recombinant production of short disulfide bond rich cystine knot peptides using barnase as a purification handle

21 January 2018

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Role of integrins in cell invasion and migration

21 January 2018

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Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

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Vascular integrins in tumor angiogenesis: mediators and therapeutic targets

21 January 2018

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Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting

21 January 2018

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Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man.

21 January 2018

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Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD

21 January 2018

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Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity

21 January 2018

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An engineered knottin peptide labeled with 18F for PET imaging of integrin expression

21 January 2018

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(64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression

21 January 2018

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Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalency

21 January 2018

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A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

21 January 2018

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Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance.

21 January 2018

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Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists

21 January 2018

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The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

21 January 2018

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The cystine knot motif in toxins and implications for drug design.

21 January 2018

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Immunogenicity of a disulphide-containing neurotoxin: presentation to T-cells requires a reduction step

21 January 2018

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Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II.

21 January 2018

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Alternative binding proteins get mature: Rivalling antibodies

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERM.10.15

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22 August 2017

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PubMed ID

20370592