Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family? (Q37725138)

22 August 2017

6 references

18 October 2019

19 November 2019

18 July 2020

7 August 2020

26 August 2020

3 October 2022

Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family? (English)

1 reference

22 August 2017

hemic and immune systems

1 reference

18 October 2019

1 reference

19 November 2019

1 reference

18 July 2020

1 reference

7 August 2020

1 reference

26 August 2020

Harold J Ting

1

1 reference

PMCID

2854111

22 August 2017

Fadi T Khasawneh

series ordinal

2

1 reference

22 August 2017

6 April 2010

7 references

Journal of Biomedical Science

22 August 2017

18 October 2019

19 November 2019

18 July 2020

7 August 2020

26 August 2020

3 October 2022

7 references

22 August 2017

18 October 2019

19 November 2019

18 July 2020

7 August 2020

26 August 2020

3 October 2022

17

1 reference

22 August 2017

1

1 reference

22 August 2017

24

1 reference

Creative Commons Attribution 2.0 Generic

22 August 2017

6 references

18 October 2019

19 November 2019

18 July 2020

7 August 2020

26 August 2020

https://scigraph.springernature.com/pub.10.1186/1423-0127-17-24

3 October 2022

0 references

0 references

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Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets

23 August 2017

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Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology

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Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model

23 August 2017

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Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading

23 August 2017

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23 August 2017

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23 August 2017

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Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways

23 August 2017

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Platelets and anti-platelet therapy.

23 August 2017

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Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin

23 August 2017

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Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking

23 August 2017

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Isoprostanes: an overview and putative roles in pulmonary pathophysiology

23 August 2017

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Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways

23 August 2017

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F(2)-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo

23 August 2017

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Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change

23 August 2017

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Platelet signal transduction pathways: could we organize them into a 'hierarchy'?

23 August 2017

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Crosstalk between Galpha(i)- and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange.

23 August 2017

1 reference

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Platelet dense granules: structure, function and implications for haemostasis.

23 August 2017

1 reference

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Identification of Galpha13 as one of the G-proteins that couple to human platelet thromboxane A2 receptors

23 August 2017

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Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

23 August 2017

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The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha

23 August 2017

1 reference

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Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles

23 August 2017

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Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or protein kinase C

23 August 2017

1 reference

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Galpha12 and galpha13 are phosphorylated during platelet activation

23 August 2017

1 reference

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23 August 2017

Platelet alpha-granules

1 reference

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G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

23 August 2017

1 reference

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Aspirin as an antiplatelet drug

23 August 2017

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Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products.

23 August 2017

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Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

23 August 2017

1 reference

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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

23 August 2017

1 reference

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Effects of the lonophore A23187 on the blood platelets II. Influence on ultrastructure.

23 August 2017

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11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation

23 August 2017

1 reference

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G proteins: transducers of receptor-generated signals

23 August 2017

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Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine

23 August 2017

1 reference

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A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

23 August 2017

1 reference

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The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Platelet Function Defects: A Clinical Review

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Platelet alpha-granule proteins: studies on release and subcellular localization

23 August 2017

1 reference

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Production of diglyceride from phosphatidylinositol in activated human platelets

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Laboratory investigation of platelet function: a review of methodology

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Augmented vasoconstriction and thromboxane formation by 15-F(2t)-isoprostane (8-iso-prostaglandin F(2alpha)) in immature pig periventricular brain microvessels

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

The role of blood platelets in nucleoside metabolism: regulation of megakaryocyte development and platelet production

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Cytosolic calcium in platelet activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Thromboxane A2 biosynthesis in human disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Interrelations of Platelet Aggregation and Secretion

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Rapid, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Coagulation and platelet activation pathways. A review of the key components and the way in which these can be manipulated

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Aggregation of human and canine platelets: modulation by purine nucleotides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Agonist receptors and G proteins as mediators of platelet activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Lipid peroxidation and platelet activation in murine atherosclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Integrin signaling: the platelet paradigm

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Evidence for the distinct nature of F2-isoprostane receptors from those of thromboxane A2.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Clinical and biochemical characteristics of a primary platelet disorder

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548).

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Involvement of endoperoxides and thromboxanes in anaphylactic reactions

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Gq/11 communicates with thromboxane A2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Physiological significance of thromboxane A(2) receptor dimerization.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Cytotoxicity of the E(2)-isoprostane 15-E(2t)-IsoP on oligodendrocyte progenitors

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Signaling mechanisms mediated by G-protein coupled receptors in human platelets

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

The putative role of isoprostanes in human cardiovascular physiology and disease: following the fingerprints

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

The isoprostanes. Current knowledge and directions for future research

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854111

Thromboxane A2/prostaglandin H2 directly stimulates platelet shape change independent of secreted ADP

1 September 2018

1 reference

12 December 2020

Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage

1 reference

12 December 2020

Regulation of megakaryocytopoiesis

1 reference

12 December 2020

Evidence that the F2-isoprostane, 8-epi-prostaglandin F2 alpha, is formed in vivo

1 reference

12 December 2020

Changes in the cytoskeletal structure of human platelets following thrombin activation

1 reference

12 December 2020

8-epi PGF2 alpha generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo

1 reference

12 December 2020

Epinephrine induced platelet aggregation in rat platelet-rich plasma

1 reference

12 December 2020

Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex

1 reference

12 December 2020

Synthesis and structure of the platelet aggregation factor thromboxane A2

1 reference

12 December 2020

Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways

1 reference

12 December 2020

The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis

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12 December 2020

Fibrinogen binding is independent of an increase in intracellular calcium concentration in thrombin degranulated platelets

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12 December 2020

Subcellular localization of alpha-subunits of trimeric G-proteins in human platelets

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12 December 2020

Is thrombin the problem or (dis)solution?

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12 December 2020

The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems

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12 December 2020

Metabolism of 8-iso-prostaglandin F2alpha

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12 December 2020

Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo

1 reference

12 December 2020

Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor

1 reference

12 December 2020

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver

1 reference

12 December 2020

Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion

1 reference

12 December 2020

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1 reference

12 December 2020

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions

1 reference

12 December 2020

Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors

1 reference

12 December 2020

Prostaglandin endoperoxides and thromboxane A2 can induce platelet aggregation in the absence of secretion

1 reference

12 December 2020

The F2-isoprostane, 8-epi-prostaglandin F2 alpha, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist

1 reference

12 December 2020

Specific analysis in plasma and urine of 2,3-dinor-5, 6-dihydro-isoprostane F(2alpha)-III, a metabolite of isoprostane F(2alpha)-III and an oxidation product of gamma-linolenic acid

1 reference

12 December 2020

Release of isoprostanes by human pulmonary artery in organ culture: a cyclo-oxygenase and nitric oxide dependent pathway

1 reference

12 December 2020

Comparative study of platelet dense granule constituents

1 reference

12 December 2020

Concomitant activation of Gi and Gq protein-coupled receptors does not require an increase in cytosolic calcium for platelet aggregation

1 reference

12 December 2020

Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets

1 reference

12 December 2020

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

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12 December 2020

Heterogeneity of prostaglandin H2/thromboxane A2 receptors: distinct subtypes mediate vascular smooth muscle contraction and platelet aggregation

1 reference

12 December 2020

Role of nonenzymatically generated prostanoid, 8-iso-PGF2 alpha, in pulmonary oxygen toxicity

1 reference

12 December 2020

Identifiers

DOI

10.1186/1423-0127-17-24

1 reference

22 August 2017

1 reference

22 August 2017

1 reference

PMCID

2854111