Kappa opioids and the modulation of pain (Q37725698)

22 August 2017

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title

Kappa opioids and the modulation of pain (English)

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22 August 2017

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1

Bronwyn Kivell

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22 August 2017

Thomas E Prisinzano

2

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22 August 2017

language of work or name

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7 April 2010

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22 August 2017

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22 August 2017

volume

210

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22 August 2017

issue

2

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22 August 2017

page(s)

109-119

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https://scigraph.springernature.com/pub.10.1007/s00213-010-1819-6

22 August 2017

exact match

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cites work

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Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding.

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The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist

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Long-lasting antinociceptive effects of a novel dynorphin analogue, Tyr-D-Ala-Phe-Leu-Arg psi (CH(2)NH) Arg-NH(2), in mice

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Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain

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12 December 2020

Effects of kappa opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension

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12 December 2020

Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones

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12 December 2020

Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal

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12 December 2020

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

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12 December 2020

Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat

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12 December 2020

Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat

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Neuroanatomy of the pain system and of the pathways that modulate pain

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Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist

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A method for evaluating both non-narcotic and narcotic analgesics

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Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans.

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12 December 2020

Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence

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12 December 2020

Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone

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12 December 2020

Brain concentrations of asimadoline in mice: the influence of coadministration of various P-glycoprotein substrates.

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12 December 2020

Peripheral analgesic actions of opioids

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12 December 2020

Assessing pain threshold in the rat: changes with estrus and time of day

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12 December 2020

Analgesic and antiinflammatory effects of two novel kappa-opioid peptides

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12 December 2020

Animal models of nociception.

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12 December 2020

Visceral polymodal receptors.

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12 December 2020

Effects of intracolonic opioid receptor agonists on polymodal pelvic nerve afferent fibers in the rat.

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12 December 2020

Animal Models of Neuropathic Pain

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12 December 2020

Serotonin and noradrenaline reuptake inhibitors in animal models of pain

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Opioids in chronic pain

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12 December 2020

Models of Visceral Nociception

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Peripheral mechanisms of opioid analgesia

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The neurobiology of nociceptive and anti-nociceptive systems

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12 December 2020

Effects of kappa opioids in the inflamed rat colon

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Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats

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12 December 2020

Antinociceptive effect of a kappa-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy

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Nociception, pain, and antinociception: current concepts

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The importance of the hypothalamo-hypophyseal-adrenal axis to the anti-inflammatory actions of the kappa-opioid agonist PNU-50,488H in rats with adjuvant arthritis.

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The formalin test: a tonic pain model in the primate

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Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors

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75 years of opioid research: the exciting but vain quest for the Holy Grail

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Azepinone as a conformational constraint in the design of kappa-opioid receptor agonists

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12 December 2020

Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man.

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Opioid receptor signaling: relevance for gastrointestinal therapy

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Bremazocine: an opiate that induces sedation and analgesia without respiratory depression

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12 December 2020

Evaluation of the supraspinal analgesic activity and abuse liability of ethylketocyclazocine.

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12 December 2020

Peripheral opioid modulation of visceral pain

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12 December 2020

Allodynia and hyperalgesia induced by herpes simplex virus type-1 infection in mice

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Peripheral mechanisms of opioid analgesia

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12 December 2020

Contribution of opioid receptors on primary afferent versus sympathetic neurons to peripheral opioid analgesia

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12 December 2020

Peripheral kappa-opioid agonists for visceral pain

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12 December 2020

Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans

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12 December 2020

PET imaging of opioid receptors in pain: progress and new directions

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12 December 2020

Peptide kappa opioid receptor ligands: potential for drug development

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12 December 2020

A model for chronic quantitative studies of colorectal sensitivity using balloon distension in conscious mice -- effects of opioid receptor agonists

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12 December 2020

Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and beta-endorphin

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12 December 2020

Analgesic potency and side action liability in man of heptazone, WIN 1161-2, 6-methyl dihydromorphine, Metopon, levo-isomethadone and pentobarbital sodium, as a further effort to refine methods of evaluation of analgesic drugs.

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12 December 2020

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12 December 2020

Lack of cross-tolerance between the antinociceptive effects of systemic morphine and asimadoline, a peripherally-selective kappa-opioid agonist, in CCI-neuropathic rats

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12 December 2020

Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation.

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12 December 2020

The increasing-temperature hot-plate test: an improved test of nociception in mice and rats

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12 December 2020

Pharmacology of metopon and other new analgesic opium derivatives

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12 December 2020

Delta and kappa opioid receptors as suitable drug targets for pain

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12 December 2020

A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist

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12 December 2020

Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis

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12 December 2020

Spinal distribution of ascending lamina I axons anterogradely labeled withPhaseolus vulgaris leucoagglutinin (PHA-L) in the cat

1 reference

12 December 2020

Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen

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12 December 2020

Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat.

1 reference

12 December 2020

The antialgesic drugs: human therapeutic correlates of their potency in laboratory animal models of hyperalgesia

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12 December 2020

Diverse immunocytochemical expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia

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12 December 2020

Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study

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12 December 2020

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

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12 December 2020

Primary afferent projections from the upper respiratory tract in the muskrat

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12 December 2020

Psychotomimesis mediated by kappa opiate receptors

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12 December 2020

Supraspinal and spinal potency of selective opioid agonists in the mouse writhing test

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12 December 2020

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study

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12 December 2020

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

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12 December 2020

Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance

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12 December 2020

Dental injury models: experimental tools for understanding neuroinflammatory interactions and polymodal nociceptor functions

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12 December 2020

Distinct distributions of mu, delta and kappa opioid receptor mRNA in rat brain

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12 December 2020

A test for analgesics as an indicator of locomotor activity in writhing mice

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12 December 2020

Novel malonamide derivatives as potent kappa opioid receptor agonists

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12 December 2020

Kappa-opioid receptors and analgesia

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12 December 2020

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse

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12 December 2020

Peripherally restricted opioid agonists as novel analgesic agents

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12 December 2020

The pain system. The neural basis of nociceptive transmission in the mammalian nervous system

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12 December 2020

Inflammation of the hind limb as a model of unilateral, localized pain: influence on multiple opioid systems in the spinal cord of the rat.

1 reference

12 December 2020

Effects of the peripherally selective kappa-opioid asimadoline, on substance P and CGRP mRNA expression in chronic arthritis of the rat.

1 reference

12 December 2020

Endogenous kappa-opioid receptor systems inhibit hyperalgesia associated with localized peripheral inflammation

1 reference

12 December 2020

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway

1 reference

12 December 2020

Scoring the mouse formalin test: validation study

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12 December 2020

The spinal cord as a site of opioid effects on gastrointestinal transit in the mouse

1 reference

12 December 2020

Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists

1 reference

12 December 2020

Inflammation of the colonic wall induced by formalin as a model of acute visceral pain

1 reference

12 December 2020

Studies of the dependence-producing potential of the narcotic antagonist 2-cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (cyclazocine, WIN-20,740, ARC II-c-3)

1 reference

12 December 2020

Effects of intracolonic acetic acid on responses to colorectal distension in the rat.

1 reference

12 December 2020

Endogenous mechanisms of sensory modulation

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12 December 2020

The peripherally acting kappa-opiate agonist EMD 61753 and analogues: opioid activity versus peripheral selectivity.

1 reference

12 December 2020

Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation

1 reference

12 December 2020

Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice

1 reference

12 December 2020

2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A

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12 December 2020

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

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12 December 2020

Lack of cross-tolerance between U69,593 and bremazocine suggests kappa-opioid receptor multiplicity in mice

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12 December 2020

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

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12 December 2020

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

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12 December 2020

Salvinorin A analogs as probes in opioid pharmacology

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12 December 2020

Effect of a kappa-opioid agonist, i.v. JNJ-38488502, on sensation of colonic distensions in healthy male volunteers

1 reference

12 December 2020

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

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12 December 2020

Mechanisms of referred visceral pain: uterine inflammation in the adult virgin rat results in neurogenic plasma extravasation in the skin.

1 reference

12 December 2020

Motivational effects of opioids in an animal model of prolonged inflammatory pain: alteration in the effects of kappa- but not of mu-receptor agonists.

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12 December 2020

Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice

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12 December 2020

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

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12 December 2020

Novel pharmacology: asimadoline, a kappa-opioid agonist, and visceral sensation

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12 December 2020

Anti-inflammatory effects of opioids

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12 December 2020

Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography

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12 December 2020

A capsaicin-receptor homologue with a high threshold for noxious heat

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12 December 2020

Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat.

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12 December 2020

A comparison of the actions of meperidine, Nu-1196, methadone, morphine, Nu-2206, and metopon upon the intestine and uterus

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12 December 2020

Impact of shock on pain reactivity: III. The magnitude of hypoalgesia observed depends on test location

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12 December 2020

Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo

1 reference

12 December 2020

Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis

1 reference

12 December 2020

Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain

1 reference

12 December 2020

Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat.

1 reference

12 December 2020

Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards

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12 December 2020

Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

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12 December 2020

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain

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12 December 2020

Pronociceptive actions of dynorphin maintain chronic neuropathic pain

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12 December 2020

Constraints on the tailflick assay: morphine analgesia and tolerance are dependent upon locus of tail stimulation

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12 December 2020

The antinociceptive effect of salvinorin A in mice

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12 December 2020

10.1007/S00213-010-1819-6

Identifiers

DOI

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22 August 2017

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