Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes (Q37728377)

22 August 2017

Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes (English)

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22 August 2017

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Hong Zhou

1

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22 August 2017

Yong-jun Li

2

1 reference

22 August 2017

Mian Wang

3

1 reference

22 August 2017

Li-hui Zhang

4

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22 August 2017

Bing-yan Guo

5

1 reference

22 August 2017

Zhan-sheng Zhao

6

1 reference

22 August 2017

Feng-ling Meng

7

1 reference

22 August 2017

Yong-gui Deng

8

1 reference

22 August 2017

Rui-ying Wang

9

1 reference

22 August 2017

11 July 2011

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Acta Pharmacologica Sinica

22 August 2017

1 reference

22 August 2017

32

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22 August 2017

8

1 reference

22 August 2017

999-1008

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https://scigraph.springernature.com/pub.10.1038/aps.2011.54

22 August 2017

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Targeted disruption of ROCK1 causes insulin resistance in vivo.

23 August 2017

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Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts

23 August 2017

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23 August 2017

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Diastolic dysfunction in hypertensive hearts: roles of perivascular inflammation and reactive myocardial fibrosis

23 August 2017

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Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

23 August 2017

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Rocks: multifunctional kinases in cell behaviour

23 August 2017

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Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic

23 August 2017

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Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy

23 August 2017

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Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta

23 August 2017

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

23 August 2017

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The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

23 August 2017

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Cell proliferation induced by reactive oxygen species is mediated via mitogen-activated protein kinase in Chinese hamster lung fibroblast (V79) cells.

14 September 2017

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Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2.

14 September 2017

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Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy

23 June 2018

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Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro

23 June 2018

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Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis

1 September 2018

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Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats

1 September 2018

1 reference

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Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction.

1 September 2018

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IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction

1 September 2018

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Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control

1 September 2018

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High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle

1 September 2018

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High-fat diets promote insulin resistance through cytokine gene expression in growing female rats

1 September 2018

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Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats

1 September 2018

1 reference

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Nongenetic model of type 2 diabetes: a comparative study.

1 September 2018

1 reference

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Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial

1 September 2018

1 reference

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Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells

1 September 2018

1 reference

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Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II.

1 September 2018

1 reference

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Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression

1 September 2018

1 reference

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Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta

1 September 2018

1 reference

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Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002528

Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts

1 September 2018

1 reference

12 December 2020

The effect of chronic alloxan- and streptozotocin-induced diabetes on isolated rat heart performance

1 reference

12 December 2020

Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury

1 reference

12 December 2020

A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats

1 reference

12 December 2020

Early failure of the diabetic heart

1 reference

12 December 2020

Identifiers

DOI

10.1038/APS.2011.54

1 reference

Dimensions Publication ID

22 August 2017

0 references

1 reference

22 August 2017

1 reference