IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction (Q46805078)

25 December 2017

title

IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction (English)

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25 December 2017

10

Piero Anversa

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8

Jan Kajstura

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Annarosa Leri

7

object named as

Annarosa Leri

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author name string

Jun Ren

1

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Jinhong Duan

2

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D Paul Thomas

3

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Xiaoping Yang

4

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Nair Sreejayan

5

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James R Sowers

6

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Annarosa Leri

7

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Jan Kajstura

8

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Feng Gao

9

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publication date

16 January 2008

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25 December 2017

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

published in

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25 December 2017

volume

294

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issue

3

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page(s)

R793-802

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25 December 2017

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction

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The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

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Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway

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Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.

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Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes

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Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells.

21 January 2018

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Protein kinase B in the diabetic heart

21 January 2018

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Cyclic AMP response element-binding protein mediates reactive oxygen species-induced c-fos expression

21 January 2018

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IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress

21 January 2018

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Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages

21 January 2018

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Impact of beta-myosin heavy chain expression on cardiac function during stress

21 January 2018

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Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.

21 January 2018

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Up-regulation of rho A and rho-kinase mRNAs in the rat myometrium during pregnancy

21 January 2018

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Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes.

21 January 2018

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IGF-I attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes

21 January 2018

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Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction

21 January 2018

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Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells

21 January 2018

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High glucose induces cardiac insulin-like growth factor I resistance in ventricular myocytes: role of Akt and ERK activation

21 January 2018

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Small guanine nucleotide-binding protein Rho and myocardial function

21 January 2018

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Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease

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Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure

21 January 2018

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RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation

21 January 2018

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Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C.

21 January 2018

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Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment

21 January 2018

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Serum insulin-like growth factor I levels in adult diabetic patients: the effect of age.

21 January 2018

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Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1

21 January 2018

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Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress.

21 January 2018

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Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production

21 January 2018

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Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide

21 January 2018

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10.1152/AJPREGU.00713.2007

21 January 2018

Identifiers

DOI

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25 December 2017

PubMed ID

18199585

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25 December 2017