Targeting Notch signaling in pancreatic cancer (Q37730861)

22 August 2017

1 reference

title

Targeting Notch signaling in pancreatic cancer (English)

1 reference

22 August 2017

1 reference

Elodie Ristorcelli

1

1 reference

PubMed ID

20392166

22 August 2017

Dominique Lombardo

series ordinal

2

1 reference

PubMed ID

20392166

22 August 2017

language of work or name

English

0 references

publication date

1 May 2010

1 reference

Expert Opinion on Therapeutic Targets

22 August 2017

1 reference

22 August 2017

14

1 reference

22 August 2017

5

1 reference

22 August 2017

541-552

1 reference

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signalling controls pancreatic cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Recent insights into the role of Notch signaling in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

The Notch pathway in cancer: differentiation gone awry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling: the demise of elegant simplicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

ADAMs in cancer cell proliferation and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

A closer look at alpha-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

ERK1/2 is an endogenous negative regulator of the gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

HES and HERP families: multiple effectors of the Notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

The multifaceted role of Notch in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Fringe is a glycosyltransferase that modifies Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling and inherited disease syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Numb regulates post-endocytic trafficking and degradation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Direct and potent regulation of gamma-secretase by its lipid microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Multiple niches for Notch in cancer: context is everything

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch gene expression during pancreatic organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling in pancreatic endocrine cell and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Identification of pancreatic cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Intercellular signals regulating pancreas development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Minireview: transcriptional regulation in pancreatic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

The Snail genes as inducers of cell movement and survival: implications in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

The many facets of Notch ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Shh signaling and pancreatic cancer: implications for therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Disruption of TGFbeta signaling pathways in human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Pancreatic cancer: pathogenesis, prevention and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch1 augments NF-kappaB activity by facilitating its nuclear retention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Evidence for the notch signaling pathway on the role of estrogen in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

JNK phosphorylates beta-catenin and regulates adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

21 January 2018

Cancer statistics, 2007

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Current therapies and advances in the treatment of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Molecular targeted therapies for pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Pancreatic cancer: current and future treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Phase II study of cisplatin, gemcitabine and 5-fluorouracil in advanced pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Immunotherapy for pancreatic cancer - science driving clinical progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

SOX9 is required for maintenance of the pancreatic progenitor cell pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling: where pancreatic cancer and differentiation meet?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Peroxisomal proliferator-activated receptor-gamma agonists induce partial reversion of epithelial-mesenchymal transition in anaplastic thyroid cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch signaling, gamma-secretase inhibitors, and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Aberrant activation of notch signaling in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Monoclonal antibody 16D10 to the COOH-terminal domain of the feto-acinar pancreatic protein targets pancreatic neoplastic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

Conditional ablation of Notch signaling in pancreatic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003769895

10.1517/14728221003769895

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20392166