Immunotherapy for pancreatic cancer - science driving clinical progress (Q36133140)

12 August 2017

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title

Immunotherapy for pancreatic cancer - science driving clinical progress (English)

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12 August 2017

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2

Elizabeth M Jaffee

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12 August 2017

Dan Laheru

1

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PubMed ID

15905855

12 August 2017

language of work or name

English

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publication date

1 June 2005

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12 August 2017

Nature Reviews Cancer

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12 August 2017

5

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12 August 2017

6

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12 August 2017

459-467

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https://scigraph.springernature.com/pub.10.1038/nrc1630

12 August 2017

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The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma.

21 January 2018

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Cancer immunotherapy: breaking the barriers to harvest the crop

21 January 2018

1 reference

Cancer immunotherapy: moving beyond current vaccines

21 January 2018

1 reference

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

21 January 2018

1 reference

VEGF as a mediator of tumor-associated immunodeficiency

21 January 2018

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Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients

21 January 2018

1 reference

BTLA: a new inhibitory receptor with a B7-like ligand

21 January 2018

1 reference

B7-H4, a molecule of the B7 family, negatively regulates T cell immunity

21 January 2018

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The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function

21 January 2018

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21 January 2018

1 reference

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

21 January 2018

1 reference

CTLA-4 ligation blocks CD28-dependent T cell activation

21 January 2018

1 reference

CD28/CTLA-4 and CD80/CD86 families: signaling and function

21 January 2018

1 reference

CD28/B7 costimulation: a review

21 January 2018

1 reference

T cell costimulatory pathways: blockade for autoimmunity

21 January 2018

1 reference

The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses

21 January 2018

1 reference

B7-H1 pathway and its role in the evasion of tumor immunity.

21 January 2018

1 reference

New regulatory co-receptors: inducible co-stimulator and PD-1.

21 January 2018

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

21 January 2018

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The roles of the new negative T cell costimulatory pathways in regulating autoimmunity

21 January 2018

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Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

21 January 2018

1 reference

Fas and Fas-ligand expression in human pancreatic cancer.

21 January 2018

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CTLA-4. FasL induces alloantigen-specific hyporesponsiveness

21 January 2018

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Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21(WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells.

21 January 2018

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Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer

21 January 2018

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Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.

21 January 2018

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TGF-beta: how tolerant can it be?

21 January 2018

1 reference

Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex

21 January 2018

1 reference

The T cell receptor/CD3 complex: a dynamic protein ensemble

21 January 2018

1 reference

Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family

21 January 2018

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The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules.

21 January 2018

1 reference

T cell antigen receptor activation pathways: The tyrosine kinase connection

21 January 2018

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The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

21 January 2018

1 reference

Tolerance, danger, and the extended family

21 January 2018

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Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

21 January 2018

1 reference

Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells

21 January 2018

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Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40.

21 January 2018

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Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells

21 January 2018

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The role of the CD40 pathway in the pathogenesis and treatment of cancer.

21 January 2018

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VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.

21 January 2018

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Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation

21 January 2018

1 reference

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

21 January 2018

1 reference

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

21 January 2018

1 reference

The EGF receptor family as targets for cancer therapy

21 January 2018

1 reference

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

21 January 2018

1 reference

Synergy between tumor immunotherapy and antiangiogenic therapy

21 January 2018

1 reference

Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial

21 January 2018

1 reference

HER-2/neu-specific monoclonal antibodies collaborate with HER-2/neu-targeted granulocyte macrophage colony-stimulating factor secreting whole cell vaccination to augment CD8+ T cell effector function and tumor-free survival in Her-2/neu-transgenic m

21 January 2018

1 reference

Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation

21 January 2018

1 reference

MUC-1 epithelial tumor mucin-based immunity and cancer vaccines

21 January 2018

1 reference

The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues

21 January 2018

1 reference

Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation

21 January 2018

1 reference

Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcino

21 January 2018

1 reference

The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas

21 January 2018

1 reference

Antitumor effect induced by dendritic cell (DC)-based immunotherapy against peritoneal dissemination of the hamster pancreatic cancer.

21 January 2018

1 reference

Development of immunotherapy for pancreatic cancer

21 January 2018

1 reference

Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method

21 January 2018

1 reference

Progress in human tumour immunology and immunotherapy

21 January 2018

1 reference

Tumor antigens recognized by T lymphocytes

21 January 2018

1 reference

Mesothelin: a new target for immunotherapy

21 January 2018

1 reference

Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays.

21 January 2018

1 reference

Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients

21 January 2018

1 reference

Vaccinia as a vector for gene delivery

21 January 2018

1 reference

TRICOM: enhanced vaccines as anticancer therapy

21 January 2018

1 reference

Advances in the development of bacterial vector technology

21 January 2018

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Mouse models of pancreatic cancer: the fur is finally flying!

21 January 2018

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

1 reference

Computational tools for protein modeling.

21 January 2018

1 reference

SYFPEITHI: database for MHC ligands and peptide motifs

21 January 2018

1 reference

Immunological escape mechanisms in pancreatic carcinoma

21 January 2018

1 reference

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

31 March 2020

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Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma

31 March 2020

1 reference

Vector-based delivery of tumor-associated antigens and T-cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity

31 March 2020

1 reference

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

Cellular mucins: targets for immunotherapy

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC1630

1 reference

PubMed ID

15905855

Dimensions Publication ID

12 August 2017

0 references

1 reference

PubMed ID

15905855