Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells (Q37737387)

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scientific article published on 24 April 2010

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English	Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells	scientific article published on 24 April 2010

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scholarly article

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Europe PubMed Central

22 August 2017

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Europe PubMed Central

Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells (English)

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Europe PubMed Central

22 August 2017

object named as

Kjetil Taskén

2

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author name string

Isabelle Cornez

1

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Europe PubMed Central

22 August 2017

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publication date

24 April 2010

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Europe PubMed Central

22 August 2017

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Europe PubMed Central

22 August 2017

584

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Europe PubMed Central

22 August 2017

2681-2688

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Europe PubMed Central

22 August 2017

12

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Europe PubMed Central

22 August 2017

Adapters in lymphocyte signalling

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21 January 2018

Positive and negative regulation of T-cell activation through kinases and phosphatases

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21 January 2018

Proximal protein tyrosine kinases in immunoreceptor signaling

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Membrane compartmentation is required for efficient T cell activation.

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Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

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Localized effects of cAMP mediated by distinct routes of protein kinase A.

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AKAP signalling complexes: focal points in space and time

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Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

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T cell antigen receptor activation pathways: The tyrosine kinase connection

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Cross-linking of CD4 and CD8 with the T-cell receptor complex: quaternary complex formation and T-cell repertoire selection

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Do CD4 and CD8 control T-cell activation via a specific tyrosine protein kinase?

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Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling

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T cell antigen receptor signaling: three families of tyrosine kinases and a phosphatase

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Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts

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The amplification of TCR signaling by dynamic membrane microdomains

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Adapter proteins in lymphocyte antigen-receptor signaling

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Lipid rafts and T-lymphocyte function: implications for autoimmunity

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T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation

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Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

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Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

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Transcriptional regulation of T lymphocyte development and function

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Adaptors and molecular scaffolds in immune cell signaling

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The role of NF-AT transcription factors in T cell activation and differentiation

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Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts

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Acquisition of transforming properties by FYN, a normal SRC-related human gene

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Three-dimensional structure of the tyrosine kinase c-Src

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

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Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor

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Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

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Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

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Constitutive activation of Src family kinases in mouse embryos that lack Csk.

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Csk controls antigen receptor-mediated development and selection of T-lineage cells.

1 reference

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Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells

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C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases

1 reference

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Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1 reference

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

1 reference

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Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

1 reference

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Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton

1 reference

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Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor

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Regulation of FynT function by dual domain docking on PAG/Cbp

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PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes

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The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function

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Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development

1 reference

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21 January 2018

Removal of C-terminal SRC kinase from the immune synapse by a new binding protein

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Protein tyrosine phosphatases in T cell physiology.

1 reference

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

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Regulation and role of adenylyl cyclase isoforms

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

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Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

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Natural versus adaptive regulatory T cells

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Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

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Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens

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miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA.

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

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Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling

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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

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CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

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p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

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Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation

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Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk

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10.1016/J.FEBSLET.2010.04.056

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

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