Gelsolin as therapeutic target in Alzheimer's disease (Q37740141)

22 August 2017

1 reference

title

Gelsolin as therapeutic target in Alzheimer's disease (English)

1 reference

22 August 2017

0 references

1

Eva Carro

1 reference

22 August 2017

language of work or name

English

0 references

publication date

1 June 2010

1 reference

Expert Opinion on Therapeutic Targets

22 August 2017

published in

1 reference

22 August 2017

volume

14

1 reference

22 August 2017

issue

6

1 reference

22 August 2017

page(s)

585-592

1 reference

Alzheimer disease therapy: can the amyloid cascade be halted?

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

The molecular pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Alzheimer's disease. In the beginning...

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Clearing the brain's amyloid cobwebs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Biology of A beta amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Beta amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: usage of a novel blood brain barrier endothelial cell model system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Megalin mediates the transport of leptin across the blood-CSF barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Oxidative stress damage and oxidative stress responses in the choroid plexus in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

The cell biology of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Inhibition of Alzheimer's amyloid-beta peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gelsolin, a multifunctional actin regulatory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Enhanced Motility in NIH 3T3 Fibroblasts That Overexpress Gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Inhibition of apoptosis by the actin-regulatory protein gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Cytoplasmic gelsolin increases mitochondrial activity and reduces Abeta burden in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Functions of gelsolin: motility, signaling, apoptosis, cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Binding of gelsolin, a secretory protein, to amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Isolation of a set of genes expressed in the choroid plexus of the mouse using suppression subtractive hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Identification of critical functional and regulatory domains in gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gelsolin is a downstream effector of rac for fibroblast motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Beta-thymosin, a modulator of the actin cytoskeleton is increased in regenerating retinal ganglion cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Neuroprotective effects of gelsolin during murine stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Neuronal apoptosis after CNS injury: the roles of glutamate and calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Actin-based plasticity in dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Signaling between the actin cytoskeleton and the postsynaptic density of dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Rapid turnover of actin in dendritic spines and its regulation by activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Regulation of the actin cycle in vivo by actin filament severing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Brain Cytochrome Oxidase in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

S-nitrosation of mitochondrial complex I depends on its structural conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Peripheral transgene expression of plasma gelsolin reduces amyloid in transgenic mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gelsolin restores A beta-induced alterations in choroid plexus epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gelsolin inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Life and death of neurons in the aging brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Gelsolin gene therapy by retrovirus producer cells for human bladder cancer in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

An experimental model of retrovirus gene therapy for malignant brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.488222

10.1517/14728222.2010.488222

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference