Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility. (Q37756119)

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2 February 2020

review article

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title

Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility (English)

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2 February 2020

6

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2 February 2020

author name string

György Dormán

1

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2 February 2020

Sándor Cseh

2

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2 February 2020

István Hajdú

3

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2 February 2020

László Barna

4

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2 February 2020

Dénes Kónya

5

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2 February 2020

László Kovács

7

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2 February 2020

Péter Ferdinandy

8

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publication date

1 May 2010

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2 February 2020

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volume

70

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issue

8

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2 February 2020

page(s)

949-964

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https://scigraph.springernature.com/pub.10.2165/11318390-000000000-00000

2 February 2020

exact match

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cites work

The design of inhibitors for medicinally relevant metalloproteins

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F11318390-000000000-00000

Zinc-binding groups modulate selective inhibition of MMPs

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F11318390-000000000-00000

Assays of matrix metalloproteinases (MMPs) activities: a review.

21 January 2018

1 reference

12 December 2020

Marimastat: BB 2516, TA 2516

1 reference

12 December 2020

Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning

1 reference

12 December 2020

Collagenolytic activity in amphibian tissues: a tissue culture assay

1 reference

12 December 2020

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

1 reference

12 December 2020

Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning.

1 reference

12 December 2020

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs

1 reference

12 December 2020

Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial.

1 reference

12 December 2020

Why do we still not have cardioprotective drugs?

1 reference

12 December 2020

Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts

1 reference

12 December 2020

Matrix metalloproteinases as valid clinical targets

1 reference

12 December 2020

Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation

1 reference

12 December 2020

Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis

1 reference

12 December 2020

Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction.

1 reference

12 December 2020

Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach

1 reference

12 December 2020

Batimastat-eluting stent implantation for the treatment of coronary artery disease: results of the Brazilian pilot study

1 reference

12 December 2020

Phosphinic peptides as zinc metalloproteinase inhibitors

1 reference

12 December 2020

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

1 reference

12 December 2020

Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition

1 reference

12 December 2020

Protease inhibitors in the clinic.

1 reference

12 December 2020

Preconditioning decreases ischemia/reperfusion-induced release and activation of matrix metalloproteinase-2

1 reference

12 December 2020

MMPs as therapeutic targets--still a viable option?

1 reference

12 December 2020

Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis

1 reference

12 December 2020

Chemically modified tetracyclines (CMT-3 and CMT-8) enable control of the pathologic remodellation of human aortic valve stenosis via MMP-9 and VEGF inhibition

1 reference

12 December 2020

Structural bases for substrate and inhibitor recognition by matrix metalloproteinases

1 reference

12 December 2020

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

1 reference

12 December 2020

Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats

1 reference

12 December 2020

The next generation of MMP inhibitors. Design and synthesis

1 reference

12 December 2020

Enhanced hit-to-lead process using bioanalogous lead evolution and chemogenomics: application in designing selective matrix metalloprotease inhibitors

1 reference

12 December 2020

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

1 reference

12 December 2020

Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.

1 reference

12 December 2020

Targeting proteases: successes, failures and future prospects

1 reference

12 December 2020

The evolution of the matrix metalloproteinase inhibitor drug discovery program at abbott laboratories

1 reference

12 December 2020

Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study

1 reference

12 December 2020

Extra binding region induced by non-zinc chelating inhibitors into the S1' subsite of matrix metalloproteinase 8 (MMP-8)

1 reference

12 December 2020

Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin)

1 reference

12 December 2020

Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation

1 reference

12 December 2020

Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart

1 reference

12 December 2020

MMP inhibitors in cardiac diseases: an update

1 reference

12 December 2020

Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

1 reference

12 December 2020

Recent advances in MMP inhibitor design

1 reference

12 December 2020

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

1 reference

12 December 2020

Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. A novel pharmacological approach for tissue remodelling-related diseases

1 reference

12 December 2020

Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity

1 reference

12 December 2020

A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MMI270 (previously termed CGS27023A) with 5-FU and folinic acid

1 reference

12 December 2020

Selective matrix metalloproteinase inhibitors for cancer

1 reference

12 December 2020

Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature

1 reference

12 December 2020

Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates

1 reference

12 December 2020

A new role for old ligands: discerning chelators for zinc metalloproteinases

1 reference

12 December 2020

Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.

1 reference

12 December 2020

Metalloproteinase inhibition by batimastat does not reduce neointimal thickening in stented atherosclerotic porcine femoral arteries

1 reference

12 December 2020

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

1 reference

12 December 2020

BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity

1 reference

12 December 2020

Advances in assays of matrix metalloproteinases (MMPs) and their inhibitors

1 reference

12 December 2020

Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches

1 reference

12 December 2020

A decade of fragment-based drug design: strategic advances and lessons learned

1 reference

12 December 2020

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

1 reference

12 December 2020

Matrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation?

1 reference

12 December 2020

Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis

1 reference

12 December 2020

Pyrimidine-2,4,6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors

1 reference

12 December 2020

The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors

1 reference

12 December 2020

Marimastat: the clinical development of a matrix metalloproteinase inhibitor

1 reference

12 December 2020

Structural basis for the highly selective inhibition of MMP-13.

1 reference

12 December 2020

Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability

1 reference

12 December 2020

Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases.

1 reference

12 December 2020

1 reference

12 December 2020

Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?

1 reference

12 December 2020

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors

1 reference

12 December 2020

Insight into the structural determinants for selective inhibition of matrix metalloproteinases

1 reference

12 December 2020

Overexpression of biglycan in the heart of transgenic mice: an antibody microarray study.

1 reference

12 December 2020

Activity-based probes for the proteomic profiling of metalloproteases

1 reference

12 December 2020

Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors

1 reference

12 December 2020