Orexin receptor antagonists: a new concept in CNS disorders? (Q37764786)

22 August 2017

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title

Orexin receptor antagonists: a new concept in CNS disorders? (English)

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22 August 2017

John Gatfield

1

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22 August 2017

Catherine Brisbare-Roch

series ordinal

2

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22 August 2017

Francois Jenck

series ordinal

3

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22 August 2017

Christoph Boss

series ordinal

4

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22 August 2017

publication date

1 August 2010

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22 August 2017

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22 August 2017

volume

5

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22 August 2017

issue

8

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22 August 2017

page(s)

1197-1214

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Investigations into the neurologic basis of narcolepsy

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins and orexin receptors: from molecules to integrative physiology

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Interactions of orexins/hypocretins with adrenocortical functions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin receptors are expressed in the adrenal medulla of the rat.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin synthesis and response in the gut.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Distribution of orexin neurons in the adult rat brain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Neurons containing hypocretin (orexin) project to multiple neuronal systems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Differential expression of orexin receptors 1 and 2 in the rat brain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductances

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Lateral hypothalamus: early developmental expression and response to hypocretin (orexin).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Gastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins activate histaminergic neurons via the orexin 2 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins/hypocretins excite basal forebrain cholinergic neurones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Hypothalamic regulation of sleep and circadian rhythms

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Reduced number of hypocretin neurons in human narcolepsy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Hypocretin (orexin) deficiency in human narcolepsy.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Promotion of sleep by targeting the orexin system in rats, dogs and humans

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin: a link between energy homeostasis and adaptive behaviour

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Effect of intraperitoneal CCK-8 on food intake and brain orexin-A after 48 h of fasting in the rat.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Nutritional status modulates behavioural and olfactory bulb Fos responses to isoamyl acetate or food odour in rats: roles of orexins and leptin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Mind versus metabolism in the control of food intake and energy balance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Central nervous system control of food intake and body weight

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Narcolepsy and the hypocretin system--where motion meets emotion

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin neurons project to diverse sympathetic outflow systems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins in the regulation of the hypothalamic-pituitary-adrenal axis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

A key role for orexin in panic anxiety.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Afferents to the orexin neurons of the rat brain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

A role for lateral hypothalamic orexin neurons in reward seeking

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Addiction and arousal: the hypocretin connection.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Arousal and reward: a dichotomy in orexin function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The orexin system regulates alcohol-seeking in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin-A expression in human peripheral tissues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Functions of orexins in peripheral tissues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Possible role of orexin A in nonadrenergic, noncholinergic inhibitory response of muscle of the mouse small intestine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Stimulatory effect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The STC-1 cells express functional orexin-A receptors coupled to CCK release

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Glucose regulates the release of orexin-a from the endocrine pancreas

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin-A-induced Ca2+ entry: evidence for involvement of trpc channels and protein kinase C regulation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Biomedical application of orexin/hypocretin receptor ligands in neuroscience

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin receptor antagonists: a review of promising compounds patented since 2006.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Orexin receptor antagonists: medicinal chemistry and therapeutic potential

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000132

7 January 2021

Identifiers

DOI

10.1002/CMDC.201000132

1 reference

22 August 2017

1 reference