Update on the pathophysiology of liver fibrosis (Q37777155)

23 August 2017

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title

Update on the pathophysiology of liver fibrosis (English)

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23 August 2017

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Massimo Pinzani

1

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PubMed ID

20678019

23 August 2017

Jose Macias-Barragan

series ordinal

2

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23 August 2017

1 August 2010

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Expert Review of Gastroenterology & Hepatology

23 August 2017

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23 August 2017

4

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23 August 2017

4

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23 August 2017

459-472

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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups

23 August 2017

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Liver fibrosis: from the bench to clinical targets

21 January 2018

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Mechanisms of hepatic fibrogenesis

21 January 2018

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Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

21 January 2018

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Matrix as a modulator of hepatic fibrogenesis

21 January 2018

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Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research

21 January 2018

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The role of circulating fibrocytes in fibrosis

21 January 2018

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Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon

21 January 2018

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The bone marrow functionally contributes to liver fibrosis.

21 January 2018

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Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.

21 January 2018

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Epithelial origin of myofibroblasts during fibrosis in the lung

21 January 2018

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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

21 January 2018

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Epithelial-to-mesenchymal transitions in the liver

21 January 2018

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Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

21 January 2018

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Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro

21 January 2018

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Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

21 January 2018

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Coagulation and fibrosis in chronic liver disease

21 January 2018

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Chemokine-directed immune cell infiltration in acute and chronic liver disease

21 January 2018

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Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis

21 January 2018

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Unraveling the spider web of hepatic stellate cell apoptosis.

21 January 2018

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Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans.

21 January 2018

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Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans

21 January 2018

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Redox mechanisms in hepatic chronic wound healing and fibrogenesis

21 January 2018

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Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids

21 January 2018

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Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.

21 January 2018

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Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice

21 January 2018

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Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

21 January 2018

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Innate and adaptive immune responses related to IBD pathogenesis

21 January 2018

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Infectious disease, the innate immune response, and fibrosis

21 January 2018

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Toll-like receptor signalling

21 January 2018

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Chemokines provide the sustained inflammatory bridge between innate and acquired immunity

21 January 2018

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Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells

21 January 2018

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Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis

21 January 2018

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Toll-like receptors and adaptor molecules in liver disease: update

21 January 2018

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TLR4 enhances TGF-beta signaling and hepatic fibrosis

21 January 2018

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A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C.

21 January 2018

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Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection

21 January 2018

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Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.

21 January 2018

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Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

21 January 2018

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Toll-like receptors as targets in chronic liver diseases

21 January 2018

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Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases

21 January 2018

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STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity.

21 January 2018

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Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.

21 January 2018

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Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis

21 January 2018

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Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners

21 January 2018

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Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells

21 January 2018

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Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution.

21 January 2018

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Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury

21 January 2018

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Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

21 January 2018

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Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells

21 January 2018

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Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells.

21 January 2018

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gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis

21 January 2018

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Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance

21 January 2018

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Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals

21 January 2018

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Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver

21 January 2018

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Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice

21 January 2018

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The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology

21 January 2018

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Leptin is essential for the hepatic fibrogenic response to chronic liver injury

21 January 2018

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Leptin deficiency reduces but does not eliminate the development of hepatic fibrosis in mice infected with Schistosoma mansoni

21 January 2018

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Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

21 January 2018

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The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies

21 January 2018

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The hormone resistin links obesity to diabetes

21 January 2018

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Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells

21 January 2018

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Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease

21 January 2018

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Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin

21 January 2018

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

21 January 2018

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Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells.

21 January 2018

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The role of the endocannabinoid system in liver diseases

21 January 2018

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Role of cannabinoids in chronic liver diseases

21 January 2018

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Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis

21 January 2018

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Antifibrogenic role of the cannabinoid receptor CB2 in the liver

21 January 2018

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Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats.

21 January 2018

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Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C.

21 January 2018

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Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice

21 January 2018

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Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

21 January 2018

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Cationic amino acid transporter-2 regulates immunity by modulating arginase activity

21 January 2018

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Mechanisms of angiogenesis and arteriogenesis

21 January 2018

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Angiogenesis in chronic inflammatory liver disease

21 January 2018

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Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers

21 January 2018

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Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis

21 January 2018

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Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis

21 January 2018

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Hepatocyte growth factor activates endothelial proangiogenic mechanisms relevant in chronic hepatitis C-associated neoangiogenesis

21 January 2018

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Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation

21 January 2018

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Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells

21 January 2018

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Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells.

21 January 2018

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Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking

21 January 2018

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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/EGH.10.47

1 reference

23 August 2017

1 reference

PubMed ID

20678019