Adoptive cell therapy: genetic modification to redirect effector cell specificity. (Q37778694)

23 August 2017

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title

Adoptive cell therapy: genetic modification to redirect effector cell specificity (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

3

Steven A Rosenberg

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

author name string

Richard A Morgan

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

Mark E Dudley

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

publication date

1 July 2010

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23 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

page(s)

336-341

1 reference

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Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity

13 May 2020

cites work

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Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen

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Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.

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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

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Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

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Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence

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Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

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Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones

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Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

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Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions

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A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

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Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells

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High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

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Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

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Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

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A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

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Gene transfer in humans using a conditionally replicating lentiviral vector

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Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

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Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains

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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

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12 December 2020

Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells

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Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

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A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

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12 December 2020

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

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Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

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Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression

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12 December 2020

Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy

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Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

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12 December 2020

Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients

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Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

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12 December 2020

Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells

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12 December 2020

Myeloid-derived suppressor cells as regulators of the immune system

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12 December 2020

The promise and potential pitfalls of chimeric antigen receptors

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12 December 2020

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

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12 December 2020

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

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12 December 2020

Blocking PD-1 in cancer immunotherapy

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12 December 2020

Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication

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12 December 2020

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

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12 December 2020

A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire

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12 December 2020

A transposon and transposase system for human application

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12 December 2020

T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing

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12 December 2020

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

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12 December 2020

Enhanced T cell receptor gene therapy for cancer

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12 December 2020

Building better chimeric antigen receptors for adoptive T cell therapy

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12 December 2020

Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial

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12 December 2020

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

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12 December 2020

Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients

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12 December 2020

Selected murine residues endow human TCR with enhanced tumor recognition

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12 December 2020

Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells

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12 December 2020

CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma

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12 December 2020

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

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12 December 2020

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

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12 December 2020

Transfer of specificity by murine alpha and beta T-cell receptor genes

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12 December 2020

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

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12 December 2020

Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report

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12 December 2020

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells

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12 December 2020

Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation

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12 December 2020

Targeting p53 as a general tumor antigen

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12 December 2020

Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors

1 reference

12 December 2020

10.1097/PPO.0B013E3181EB3879

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6348476&resulttype=core&format=json

13 May 2020

1 reference