A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity (Q39785306)

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scientific article published on November 2009

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English	A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity	scientific article published on November 2009

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scholarly article

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity (English)

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Steven Rosenberg

9

object named as

Steven A Rosenberg

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

author name string

Yangbing Zhao

1

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Qiong J Wang

2

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Shicheng Yang

3

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

James N Kochenderfer

4

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Zhili Zheng

5

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Xiaosong Zhong

6

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Michel Sadelain

7

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Zelig Eshhar

8

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Richard A Morgan

10

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

language of work or name

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publication date

1 November 2009

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Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

Journal of Immunology

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Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

183

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Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

9

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

5563-5574

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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UpGene: Application of a web-based DNA codon optimization algorithm

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

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Costimulation of human CD28- T cells by 4-1BB ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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Cancer regression in patients after transfer of genetically engineered lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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A new era for cancer immunotherapy based on the genes that encode cancer antigens

1 reference

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Utility of c-erbB-2 expression in tissue and sera of ovarian cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

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Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

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4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

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Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

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ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

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Clinical trial results of a HER2/neu (E75) vaccine to prevent recurrence in high-risk breast cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

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Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of the NKG2D immunoreceptor and its ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy through TCR gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB-mediated immunotherapy of rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of Cardiac Dysfunction in a Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Paclitaxel, With or Without Trastuzumab As Adjuvant Therapy in Node-Positive, Human Epidermal Growth Factor Receptor 2–Overexpressing Bre

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The T-body approach: redirecting T cells with antibody specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting tumours with genetically enhanced T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF/TNFR family members in costimulation of T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanization of an anti-p185HER2 antibody for human cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immuno-gene therapy of established prostate tumors using chimeric receptor-redirected human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the immune response through 4-1BB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HER-2/neu antigen loss and relapse of mammary carcinoma are actively induced by T cell-mediated anti-tumor immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene modification strategies to induce tumor immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The makings of a tumor rejection antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19843940

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.0900447

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

1 reference

Europe PubMed Central

3 July 2019

http://europepmc.org/abstract/PMC/6292203

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