Importance of disrupted intestinal barrier in inflammatory bowel diseases (Q37781315)

23 August 2017

Importance of disrupted intestinal barrier in inflammatory bowel diseases (English)

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inflammatory bowel diseases

23 August 2017

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inflammation

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author name string

Sa'ad Y Salim

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1

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PubMed ID

20725949

23 August 2017

Johan D Söderholm

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2

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23 August 2017

19 August 2010

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Inflammatory Bowel Diseases

23 August 2017

20

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based on heuristic

inferred from page(s)

published in

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23 August 2017

17

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23 August 2017

362-381

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23 August 2017

1

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Inflammatory Bowel Disease

23 August 2017

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Intestinal permeability: an overview

21 January 2018

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Insights into IBD Pathogenesis

21 January 2018

1 reference

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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Role of intestinal flora in the development of allergy

21 January 2018

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The gut microbiota as an environmental factor that regulates fat storage

21 January 2018

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Molecular analysis of commensal host-microbial relationships in the intestine

21 January 2018

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A microbial symbiosis factor prevents intestinal inflammatory disease

21 January 2018

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The gut microbiota shapes intestinal immune responses during health and disease

21 January 2018

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Do symbiotic bacteria subvert host immunity?

21 January 2018

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Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut.

21 January 2018

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Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens

21 January 2018

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Structure of the intestinal flora responsible for development of the gut immune system in a rodent model

21 January 2018

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The effect of weaning on the clonality of alpha beta T-cell receptor T cells in the intestine of GF and SPF mice

21 January 2018

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Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis

21 January 2018

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21 January 2018

Probiotics and immunity

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Beneficial effects of Bacteroides fragilis polysaccharides on the immune system

21 January 2018

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Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells

21 January 2018

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Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

21 January 2018

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

21 January 2018

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Intestinal mucosal barrier function in health and disease

21 January 2018

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The immune geography of IgA induction and function

21 January 2018

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Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria.

21 January 2018

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Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

21 January 2018

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Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria

21 January 2018

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Intestinal IgA synthesis: regulation of front-line body defences

21 January 2018

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21 January 2018

The intestinal stem cell

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Decoding the patterns of self and nonself by the innate immune system

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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War and peace at mucosal surfaces

21 January 2018

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Crohn's disease--defect in innate defence.

21 January 2018

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Immune responses to the microbiota at the intestinal mucosal surface

21 January 2018

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Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

21 January 2018

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

21 January 2018

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21 January 2018

Human TSLP-educated DCs.

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TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis.

21 January 2018

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Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells.

21 January 2018

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Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria

21 January 2018

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Collaboration of epithelial cells with organized mucosal lymphoid tissues.

21 January 2018

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The composition and function of M cell apical membranes: implications for microbial pathogenesis

21 January 2018

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Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease

21 January 2018

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Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.

21 January 2018

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M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis.

21 January 2018

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Epithelial M cells: gateways for mucosal infection and immunization

21 January 2018

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Compartmentalization of the mucosal immune responses to commensal intestinal bacteria

21 January 2018

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Phenotype and function of intestinal dendritic cells

21 January 2018

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Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

21 January 2018

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Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells

21 January 2018

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Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

21 January 2018

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Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection.

21 January 2018

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Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection

21 January 2018

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Intestinal permeability: functional assessment and significance

21 January 2018

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Intestinal permeability, leaky gut, and intestinal disorders

21 January 2018

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Permeable junctional complexes. The movement of lanthanum across rabbit gallbladder and intestine

21 January 2018

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Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia

21 January 2018

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Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport

21 January 2018

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Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships

21 January 2018

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Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

21 January 2018

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Molecular mechanism of intestinal permeability: interaction at tight junctions

21 January 2018

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Inflammatory bowel disease and the apical junctional complex

21 January 2018

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Multifunctional strands in tight junctions

21 January 2018

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Claudins in occluding junctions of humans and flies

21 January 2018

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21 January 2018

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Epithelial transport and barrier function in occludin-deficient mice

21 January 2018

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Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration

21 January 2018

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Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease

21 January 2018

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The role of JAM-A in inflammatory bowel disease: unrevealing the ties that bind

21 January 2018

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Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability

21 January 2018

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Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

21 January 2018

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Tight junctions: molecular structure meets function.

21 January 2018

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In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death

21 January 2018

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Molecular components of the adherens junction.

21 January 2018

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Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium

21 January 2018

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Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease.

21 January 2018

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Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

21 January 2018

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Endocytic mechanisms for targeted drug delivery

21 January 2018

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The coated pit and macropinocytic pathways serve distinct endosome populations

21 January 2018

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Factors affecting antigen uptake by human intestinal epithelial cell lines

21 January 2018

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Regulated portals of entry into the cell

21 January 2018

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Lipid raft organization and function in the small intestinal brush border

21 January 2018

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Membrane traffic and the cellular uptake of cholera toxin

21 January 2018

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Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

21 January 2018

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Gut barrier dysfunction as detected by intestinal luminal microdialysis

21 January 2018

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In vitro methods to study intestinal drug metabolism

21 January 2018

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Advances in methods to evaluate gastrointestinal transport function

21 January 2018

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In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell.

21 January 2018

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A guide to Ussing chamber studies of mouse intestine

21 January 2018

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Analysis of unstirred water layer in in vitro permeability experiments.

21 January 2018

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Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

21 January 2018

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The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications

21 January 2018

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Permeability for intestinal absorption: Caco-2 assay and related issues

21 January 2018

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M-cell targeting of whole killed bacteria induces protective immunity against gastrointestinal pathogens.

21 January 2018

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Unravelling the pathogenesis of inflammatory bowel disease

21 January 2018

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21 January 2018

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The immunological and genetic basis of inflammatory bowel disease

21 January 2018

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Inflammatory bowel disease: new insights into pathogenesis and treatment

21 January 2018

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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

21 January 2018

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The genetic basis of inflammatory bowel disease.

21 January 2018

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Inflammatory bowel disease: review from the aspect of genetics

21 January 2018

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Evolving paradigms in the pathogenesis of IBD.

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

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TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

21 January 2018

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

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Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

21 January 2018

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Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant

21 January 2018

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Human IRGM induces autophagy to eliminate intracellular mycobacteria

21 January 2018

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

21 January 2018

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Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease

21 January 2018

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IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

21 January 2018

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

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Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

21 January 2018

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Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk

21 January 2018

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Genome-wide association identifies multiple ulcerative colitis susceptibility loci

21 January 2018

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Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging.

21 January 2018

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Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease

21 January 2018

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Increased transmucosal uptake of E. coli K12 in collagenous colitis persists after budesonide treatment

21 January 2018

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Clustering of increased small intestinal permeability in families with Crohn's disease.

21 January 2018

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Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk

21 January 2018

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Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease

21 January 2018

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Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?

21 January 2018

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The primary defect in experimental ileitis originates from a nonhematopoietic source

21 January 2018

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Predicting relapse in Crohn's disease: a biopsychosocial model

21 January 2018

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Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine

21 January 2018

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(51)CrEDTA colonic permeability and therapy response in patients with ulcerative colitis

21 January 2018

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Increased colonic permeability in patients with ulcerative colitis: an in vitro study.

21 January 2018

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Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

21 January 2018

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Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis

21 January 2018

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Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases.

21 January 2018

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Mucosal flora in inflammatory bowel disease

21 January 2018

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Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease

21 January 2018

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Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics

21 January 2018

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High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

21 January 2018

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Type 1 pili-mediated adherence of Escherichia coli strain LF82 isolated from Crohn's disease is involved in bacterial invasion of intestinal epithelial cells.

21 January 2018

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Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria

21 January 2018

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Role of intestinal microflora in chronic inflammation and ulceration of the rat colon

21 January 2018

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Intestinal inflammation and the gut microflora

21 January 2018

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Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat.

21 January 2018

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Low counts of Faecalibacterium prausnitzii in colitis microbiota.

21 January 2018

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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

21 January 2018

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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 January 2018

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A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease

21 January 2018

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NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

21 January 2018

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A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon

21 January 2018

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Reduced Paneth cell alpha-defensins in ileal Crohn's disease

21 January 2018

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Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha

21 January 2018

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Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry

21 January 2018

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Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease.

21 January 2018

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Enterocyte cytoskeleton changes are crucial for enhanced translocation of nonpathogenic Escherichia coli across metabolically stressed gut epithelia

21 January 2018

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Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.

21 January 2018

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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease

21 January 2018

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Subclinical intestinal inflammation: an inherited abnormality in Crohn’s disease relatives?

21 January 2018

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Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn?s disease

21 January 2018

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Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcome

21 January 2018

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Profile of soluble cytokine receptors in Crohn's disease

21 January 2018

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Polarized production of T-helper cell type 1 cells in Peyer's patches in Crohn's disease.

21 January 2018

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Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.

21 January 2018

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TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation

21 January 2018

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Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2

21 January 2018

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Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease

21 January 2018

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Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment

21 January 2018

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Disrupted barrier function through epithelial cell apoptosis

21 January 2018

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A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.

21 January 2018

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Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression

21 January 2018

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Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line.

21 January 2018

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Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter

21 January 2018

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Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier

21 January 2018

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Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment

21 January 2018

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Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process

21 January 2018

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Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane

21 January 2018

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Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers

21 January 2018

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Mechanism of interferon-gamma-induced increase in T84 intestinal epithelial tight junction

21 January 2018

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Phosphatidylinositol 3'-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability.

21 January 2018

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Dendritic cells in intestinal immune regulation.

21 January 2018

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21 January 2018

Mucosal dendritic cells

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CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

21 January 2018

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CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease.

21 January 2018

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Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease

21 January 2018

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Evolving knowledge and therapy of inflammatory bowel disease

21 January 2018

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A randomized controlled study comparing elemental diet and steroid treatment in Crohn's disease.

21 January 2018

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Impact of different therapeutic regimens on the outcome of patients with Crohn's disease of the upper gastrointestinal tract

21 January 2018

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The mechanisms of prednisone inhibition of inflammation in Crohn's disease involve changes in intestinal permeability, mucosal TNFalpha production and nuclear factor kappa B expression

21 January 2018

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Mechanism of glucocorticoid regulation of the intestinal tight junction barrier

21 January 2018

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Biologic therapy of inflammatory bowel disease.

21 January 2018

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The effect of probiotic bacteria on the adhesion of pathogens to human intestinal mucus.

21 January 2018

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Lactobacillus acidophilus LA 1 binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria

21 January 2018

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Influence of Saccharomyces boulardii on the intestinal permeability of patients with Crohn's disease in remission

21 January 2018

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Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis

21 January 2018

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Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: a pilot study.

21 January 2018

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Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine

21 January 2018

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Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis.

21 January 2018

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Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells.

21 January 2018

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VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation

21 January 2018

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Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2.

21 January 2018

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The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells

21 January 2018

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Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

21 January 2018

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Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair

21 January 2018

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Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis.

21 January 2018

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Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

21 January 2018

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Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats

21 January 2018

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Modulation of the effect of dextran sulfate sodium-induced acute colitis by the administration of different probiotic strains of Lactobacillus and Bifidobacterium.

21 January 2018

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Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse

21 January 2018

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Stress impairs murine intestinal barrier function: improvement by glucagon-like peptide-2.

21 January 2018

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Epithelial tight junctions in intestinal inflammation

21 January 2018

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Intraepithelial lymphocytes express junctional molecules in murine small intestine

21 January 2018

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Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

21 January 2018

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VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IBD.21403

1 reference

23 August 2017

1 reference

PubMed ID

20725949