Current perspectives of natural killer cell education by MHC class I molecules (Q37785488)

23 August 2017

Current perspectives of natural killer cell education by MHC class I molecules (English)

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23 August 2017

Petter Brodin

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author name string

Petter Höglund

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1

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23 August 2017

6 September 2010

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Nature Reviews Immunology

23 August 2017

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23 August 2017

10

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23 August 2017

10

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23 August 2017

724-734

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Adaptive immune features of natural killer cells

23 August 2017

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T cell- and B cell-independent adaptive immunity mediated by natural killer cells.

31 March 2020

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Cytokine-induced memory-like natural killer cells

31 March 2020

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Human natural killer cell deficiencies

31 March 2020

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KIR and disease: a model system or system of models?

31 March 2020

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NK cells: elusive players in autoimmunity

31 March 2020

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Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.

31 March 2020

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Empty MHC class I molecules come out in the cold

31 March 2020

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

31 March 2020

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Induction of Immunity and of Unresponsiveness to Parental Marrow Grafts in Adult F1 Hybrid Mice

31 March 2020

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Genetic control of bone marrow graft rejection. I. Determinant-specific difference of reactivity in two pairs of inbred mouse strains

31 March 2020

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Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts

31 March 2020

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Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice

31 March 2020

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Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice

31 March 2020

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MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

31 March 2020

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Licensing of natural killer cells by host major histocompatibility complex class I molecules

31 March 2020

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Human NK cell education by inhibitory receptors for MHC class I.

31 March 2020

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Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules

31 March 2020

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A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules

31 March 2020

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Unravelling natural killer cell function: triggering and inhibitory human NK receptors

31 March 2020

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31 March 2020

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MHC class I molecules and KIRs in human history, health and survival

31 March 2020

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Evolution of the Ly49 and Nkrp1 recognition systems

31 March 2020

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

31 March 2020

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Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)

31 March 2020

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Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection.

31 March 2020

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Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells

31 March 2020

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Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors

31 March 2020

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Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice.

31 March 2020

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Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice

31 March 2020

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MHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity

31 March 2020

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Activity and phenotype of natural killer cells in peptide transporter (TAP)-deficient patients (type I bare lymphocyte syndrome)

31 March 2020

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The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells

31 March 2020

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'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection

31 March 2020

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Dendritic cells prime natural killer cells by trans-presenting interleukin 15

31 March 2020

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Cutting edge: Priming of NK cells by IL-18.

31 March 2020

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Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk

31 March 2020

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Inhibitory receptors signal activation

31 March 2020

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Licensing of natural killer cells by self-major histocompatibility complex class I.

31 March 2020

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Self-tolerance of natural killer cells

31 March 2020

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Cis association of Ly49A with MHC class I restricts natural killer cell inhibition

31 March 2020

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H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function

31 March 2020

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A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

31 March 2020

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Quantifying the reduction in accessibility of the inhibitory NK cell receptor Ly49A caused by binding MHC class I proteins in cis

31 March 2020

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Distinct Conformations of Ly49 Natural Killer Cell Receptors Mediate MHC Class I Recognition in Trans and Cis

31 March 2020

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NK cell education: not an on-off switch but a tunable rheostat.

31 March 2020

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NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model

31 March 2020

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Beyond licensing and disarming: a quantitative view on NK-cell education

31 March 2020

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Up on the tightrope: natural killer cell activation and inhibition

31 March 2020

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Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity

31 March 2020

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Activation, coactivation, and costimulation of resting human natural killer cells

31 March 2020

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Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase

31 March 2020

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MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

31 March 2020

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Education of human natural killer cells by activating killer cell immunoglobulin-like receptors

31 March 2020

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Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1.

31 March 2020

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Effects of MHC class I alleles on licensing of Ly49A+ NK cells.

31 March 2020

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Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP-2) Can Play a Direct Role in the Inhibitory Function of Killer Cell Ig-Like Receptors in Human NK Cells

31 March 2020

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Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

31 March 2020

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31 March 2020

12 December 2020

SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation

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Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.

31 March 2020

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Natural killer cell tolerance licensing and other mechanisms.

31 March 2020

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Natural killer cells: diversity in search of a niche

31 March 2020

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Identification of probabilistic transcriptional switches in the Ly49 gene cluster: a eukaryotic mechanism for selective gene activation

31 March 2020

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Identification of bidirectional promoters in the human KIR genes

31 March 2020

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KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression.

31 March 2020

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Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice

31 March 2020

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Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor repertoire.

31 March 2020

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MHC-dependent shaping of the inhibitory Ly49 receptor repertoire on NK cells: evidence for a regulated sequential model.

31 March 2020

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A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors

31 March 2020

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Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.

31 March 2020

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Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways

31 March 2020

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Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

31 March 2020

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Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo

31 March 2020

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Continuous engagement of a self-specific activation receptor induces NK cell tolerance

31 March 2020

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Tolerance of NK cells encountering their viral ligand during development

31 March 2020

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How do natural killer cells find self to achieve tolerance?

31 March 2020

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Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype

31 March 2020

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MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells

31 March 2020

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Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors

31 March 2020

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HLA alleles determine differences in human natural killer cell responsiveness and potency

31 March 2020

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Natural killer cell developmental pathways: a question of balance.

31 March 2020

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Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

31 March 2020

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Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation

31 March 2020

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Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.

31 March 2020

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Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.

31 March 2020

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Multiplicity and plasticity of natural killer cell signaling pathways

31 March 2020

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Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.

31 March 2020

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Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45

31 March 2020

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LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor

31 March 2020

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NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

31 March 2020

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NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway

31 March 2020

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DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo

31 March 2020

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NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

31 March 2020

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DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming

31 March 2020

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A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

31 March 2020

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Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production

31 March 2020

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Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

31 March 2020

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Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

31 March 2020

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Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

31 March 2020

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NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy

31 March 2020

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Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice

31 March 2020

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Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

31 March 2020

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Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells

31 March 2020

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Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells

31 March 2020

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The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion

31 March 2020

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p110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells

31 March 2020

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The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

31 March 2020

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Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells

31 March 2020

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Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.

31 March 2020

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Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

31 March 2020

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12 December 2020

Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice

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12 December 2020

NK cell response to viral infections in beta 2-microglobulin-deficient mice.

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12 December 2020

Enhanced generation of NK cells with intact cytotoxic function in CD45 exon 6-deficient mice

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12 December 2020

Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1.

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12 December 2020

DEFICIENT GROWTH OF C57BL MARROW CELLS TRANSPLANTED IN F1 HYBRID MICE. ASSOCIATION WITH THE HISTOCOMPATIBILITY-2 LOCUS

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12 December 2020

Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity.

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12 December 2020

Identifiers

DOI

10.1038/NRI2835

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23 August 2017

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PubMed ID

20818413