T regulatory cells in cancer: recent advances and therapeutic potential (Q37800935)

23 August 2017

T regulatory cells in cancer: recent advances and therapeutic potential (English)

1 reference

23 August 2017

Eyad Elkord

1

1 reference

23 August 2017

Erik M Alcantar-Orozco

2

1 reference

23 August 2017

Simon J Dovedi

3

1 reference

23 August 2017

Dat Q Tran

4

1 reference

23 August 2017

Robert E Hawkins

5

1 reference

23 August 2017

David E Gilham

6

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23 August 2017

language of work or name

English

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publication date

1 November 2010

1 reference

Expert Opinion on Biological Therapy

23 August 2017

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23 August 2017

10

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23 August 2017

11

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23 August 2017

1573-1586

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Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy

23 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Natural versus adaptive regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory T cells: how do they suppress immune responses?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Immunosuppressive networks in the tumour environment and their therapeutic relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory T cells, tumour immunity and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Renal Cell Carcinoma Induces Prostaglandin E2 and T-Helper Type 2 Cytokine Production in Peripheral Blood Mononuclear Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Frequency and gene expression profile of regulatory T cells in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory T cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory T cells and treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Functional characterization of EBV-encoded nuclear antigen 1-specific CD4+ helper and regulatory T cells elicited by in vitro peptide stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Myeloid-derived suppressor cells as regulators of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Role of LAG-3 in regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

ICOS co-stimulatory receptor is essential for T-cell activation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Pharmacogenomic approach for the identification of novel determinants of acquired resistance to oxaliplatin in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory T cells in tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Inability to mediate prolonged reduction of regulatory T Cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Cutting edge: programmed death-1 defines CD8+CD122+ T cells as regulatory versus memory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

CD4 regulatory T cells in human cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

FOXP3 defines regulatory T cells in human tumor and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

The anticancer immune response: indispensable for therapeutic success?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Targeted knock down of CCL22 and CCL17 by siRNA during DC differentiation and maturation affects the recruitment of T subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Immunoregulatory T cells: role and potential as a target in malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Vaccination against the Forkhead Family Transcription Factor Foxp3 Enhances Tumor Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

FOXP3 expression and overall survival in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.529126

10.1517/14712598.2010.529126

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference