Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? (Q37815613)

23 August 2017

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title

Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? (English)

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23 August 2017

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3

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Gaspare Gulotta

7

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Daniele Santini

6

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Viviana Bazan

8

object named as

Viviana Bazan

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23 August 2017

5

Nicola Silvestris

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23 August 2017

Sergio Rizzo

1

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23 August 2017

Giuseppe Bronte

2

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23 August 2017

Lidia Corsini

4

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23 August 2017

Nicola Gebbia

9

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23 August 2017

Fabio Fulfaro

10

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23 August 2017

Antonio Russo

11

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23 August 2017

1 November 2010

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23 August 2017

Cancer Treatment Reviews

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23 August 2017

36 Suppl 3

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23 August 2017

S56-61

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Global cancer statistics, 2002

23 August 2017

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EGFR signaling and drug discovery.

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Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

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Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab

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Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab

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PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

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Hyperactive Ras in developmental disorders and cancer

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Untangling the ErbB signalling network

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Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

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Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study

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K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients

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Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

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7 January 2021

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

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7 January 2021

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

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Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer

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A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer

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Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer

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Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype

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Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

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Moyamoya disease and moyamoya syndrome

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KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer.

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Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

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Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers.

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High frequency of mutations of the PIK3CA gene in human cancers

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Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.

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Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis

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PTEN gene mutations in colorectal cancers displaying microsatellite instability

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PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients

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Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.

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PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer.

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Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab

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Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study

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7 January 2021

10.1016/S0305-7372(10)70021-9

Identifiers

DOI

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23 August 2017

1 reference