Hyperactive Ras in developmental disorders and cancer (Q29616397)

Europe PubMed Central

title

Hyperactive Ras in developmental disorders and cancer (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

author name string

Schubbert S

series ordinal

1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

Shannon K

series ordinal

2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

Bollag G

series ordinal

3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

language of work or name

1 reference

30 April 2017

publication date

April 2007

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

published in

Nature Reviews Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

volume

7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

issue

4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

30 April 2017

page(s)

295-308

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

The beta-PDGF receptor induces neuronal differentiation of PC12 cells

30 April 2017

cites work

1 reference

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

21 January 2018

1 reference

Biochemical characterization of polypeptides encoded by mutated human Ha-ras1 genes

21 January 2018

1 reference

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

1 reference

Multiple Lentigenes Syndrome

21 January 2018

1 reference

HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.

21 January 2018

1 reference

HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

21 January 2018

1 reference

The GTPase superfamily: a conserved switch for diverse cell functions

21 January 2018

1 reference

The GTPase superfamily: conserved structure and molecular mechanism

31 March 2020

1 reference

The guanine nucleotide-binding switch in three dimensions

31 March 2020

1 reference

NF1 tumor suppressor gene function: narrowing the GAP

31 March 2020

1 reference

Noonan syndrome and related disorders: genetics and pathogenesis

31 March 2020

1 reference

Stops along the RAS pathway in human genetic disease

31 March 2020

1 reference

Germline mutations in HRAS proto-oncogene cause Costello syndrome

31 March 2020

1 reference

PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

31 March 2020

1 reference

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

31 March 2020

1 reference

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

31 March 2020

1 reference

Germline KRAS mutations cause Noonan syndrome

31 March 2020

1 reference

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

31 March 2020

1 reference

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

31 March 2020

1 reference

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

31 March 2020

1 reference

Proteins regulating Ras and its relatives

31 March 2020

1 reference

Signaling interplay in Ras superfamily function

31 March 2020

1 reference

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

31 March 2020

1 reference

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

31 March 2020

1 reference

Signal transduction and the Ets family of transcription factors

31 March 2020

1 reference

Ras and Rho regulation of the cell cycle and oncogenesis

31 March 2020

1 reference

Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

1 reference

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

31 March 2020

1 reference

Oncogenic PI3K deregulates transcription and translation

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

Exploiting the PI3K/AKT pathway for cancer drug discovery

31 March 2020

1 reference

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

31 March 2020

1 reference

Ras caught in another affair: the exchange factors for Ral.

31 March 2020

1 reference

RalGDS is required for tumor formation in a model of skin carcinogenesis.

31 March 2020

1 reference

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

31 March 2020

1 reference

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

31 March 2020

1 reference

Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras.

31 March 2020

1 reference

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

31 March 2020

1 reference

Phospholipase C(epsilon): a novel Ras effector

31 March 2020

1 reference

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

31 March 2020

1 reference

Targeting RAS signalling pathways in cancer therapy

31 March 2020

1 reference

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

31 March 2020

1 reference

K-ras is essential for the development of the mouse embryo

31 March 2020

1 reference

K-Ras is essential for normal fetal liver erythropoiesis

31 March 2020

1 reference

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

31 March 2020

1 reference

The murine N-ras gene is not essential for growth and development

31 March 2020

1 reference

Compartmentalized Ras/MAPK signaling

31 March 2020

1 reference

Ras redux: rethinking how and where Ras acts.

31 March 2020

1 reference

Ras signaling from plasma membrane and endomembrane microdomains

31 March 2020

1 reference

Ras signalling on the endoplasmic reticulum and the Golgi

31 March 2020

1 reference

Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation

31 March 2020

1 reference

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

31 March 2020

1 reference

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

31 March 2020

1 reference

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

31 March 2020

1 reference

Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane

31 March 2020

1 reference

Differential modification of Ras proteins by ubiquitination

31 March 2020

1 reference

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

31 March 2020

1 reference

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

31 March 2020

1 reference

Biological and biochemical properties of human rasH genes mutated at codon 61.

31 March 2020

1 reference

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

31 March 2020

1 reference

The effector interactions of p21ras

31 March 2020

1 reference

Multiple Ras functions can contribute to mammalian cell transformation

31 March 2020

1 reference

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

31 March 2020

1 reference

Distinct requirements for Ras oncogenesis in human versus mouse cells

31 March 2020

1 reference

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

31 March 2020

1 reference

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

31 March 2020

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

1 reference

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

31 March 2020

1 reference

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

31 March 2020

1 reference

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

31 March 2020

1 reference

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

31 March 2020

1 reference

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

31 March 2020

1 reference

Inducible gene targeting in mice

31 March 2020

1 reference

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

31 March 2020

1 reference

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

31 March 2020

1 reference

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

31 March 2020

1 reference

SIGNAL TRANSDUCTION: Prelude to an Anniversary for the RAS Oncogene

31 March 2020

1 reference

RAS oncogenes: the first 30 years.

31 March 2020

1 reference

Neurofibromatosis Type 1 Due to Germ-Line Mosaicism in a Clinically Normal Father

31 March 2020

1 reference

Epidemiology of neurofibromatosis type 1 (NF1) in northern Finland

31 March 2020

1 reference

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

31 March 2020

1 reference

cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product

31 March 2020

1 reference

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

31 March 2020

1 reference

The neurofibromatosis type 1 gene encodes a protein related to GAP

31 March 2020

1 reference

31 March 2020

1 reference

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

31 March 2020

1 reference

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

31 March 2020

1 reference

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

31 March 2020

1 reference

The role of Shp2 (PTPN11) in cancer.

31 March 2020

1 reference

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

31 March 2020

1 reference

Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response

31 March 2020

1 reference

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

31 March 2020

1 reference

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

31 March 2020

1 reference

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

31 March 2020

1 reference

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

31 March 2020

1 reference

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

31 March 2020

1 reference

Identification of a putative Syp substrate, the PDGF beta receptor

31 March 2020

1 reference

Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

31 March 2020

1 reference

Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

31 March 2020

1 reference

Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases.

31 March 2020

1 reference

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

31 March 2020

1 reference

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

31 March 2020

1 reference

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

31 March 2020

1 reference

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

31 March 2020

1 reference

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

31 March 2020

1 reference

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

31 March 2020

1 reference

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

31 March 2020

1 reference

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

31 March 2020

1 reference

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

31 March 2020

1 reference

Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.

31 March 2020

1 reference

Diversity, parental germline origin, and phenotypic spectrum of de novoHRASmissense changes in Costello syndrome

31 March 2020

1 reference

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

31 March 2020

1 reference

Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations

31 March 2020

1 reference

Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily

31 March 2020

1 reference

Mutations of the BRAF gene in human cancer

31 March 2020

1 reference

The RAF proteins take centre stage

31 March 2020

1 reference

Guilty as charged: B-RAF is a human oncogene

31 March 2020

1 reference

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

31 March 2020

1 reference

High frequency of BRAF mutations in nevi

31 March 2020

1 reference

Mutations of the BRAF gene in benign and malignant melanocytic lesions

31 March 2020

1 reference

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

31 March 2020

1 reference

BRAF mutation predicts sensitivity to MEK inhibition

31 March 2020

1 reference

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

31 March 2020

1 reference

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

31 March 2020

1 reference

Structural analysis of autoinhibition in the Ras activator Son of sevenless

31 March 2020

1 reference

Genetic screening for signal transduction in the era of network biology

31 March 2020

1 reference

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.

31 March 2020

1 reference

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

31 March 2020

1 reference

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

31 March 2020

1 reference

The structural basis of the activation of Ras by Sos

31 March 2020

1 reference

Inherited predispositions and hyperactive Ras in myeloid leukemogenesis

31 March 2020

1 reference

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

31 March 2020

1 reference

SHP-2 and myeloid malignancies

31 March 2020

1 reference

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

31 March 2020

1 reference

Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

31 March 2020

1 reference

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

31 March 2020

1 reference

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

8466

1040267703

0 references

8466

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17384584

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017