Recombinant antibodies: engineering and production in yeast and bacterial hosts (Q37822354)

23 August 2017

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title

Recombinant antibodies: engineering and production in yeast and bacterial hosts (English)

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23 August 2017

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3

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author name string

Ki Jun Jeong

series ordinal

1

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23 August 2017

Seung Hoon Jang

series ordinal

2

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23 August 2017

publication date

1 January 2011

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23 August 2017

published in

Biotechnology Journal

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23 August 2017

volume

6

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23 August 2017

issue

1

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23 August 2017

page(s)

16-27

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Research and development of next generation of antibody-based therapeutics

23 August 2017

cites work

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21 January 2018

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Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

21 January 2018

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High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

21 January 2018

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

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Engineering therapeutic monoclonal antibodies

21 January 2018

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

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Reduced elimination of IgG antibodies by engineering the variable region.

21 January 2018

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Enhanced antibody half-life improves in vivo activity

21 January 2018

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Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties

21 January 2018

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Optimization of humanized IgGs in glycoengineered Pichia pastoris.

21 January 2018

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Definition of the bacterial N-glycosylation site consensus sequence

21 January 2018

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Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli.

21 January 2018

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A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation

21 January 2018

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Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

21 January 2018

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Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells

21 January 2018

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Efficient expression and purification of human aglycosylated Fcgamma receptors in Escherichia coli.

21 January 2018

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Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

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Process economics of industrial monoclonal antibody manufacture

21 January 2018

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Engineering of Pichia pastoris for improved production of antibody fragments.

21 January 2018

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Antibody production with yeasts and filamentous fungi: on the road to large scale?

21 January 2018

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Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae

21 January 2018

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Cooverexpression of chaperones for enhanced secretion of a single-chain antibody fragment in Pichia pastoris.

21 January 2018

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Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line

21 January 2018

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Effects of inactivation and constitutive expression of the unfolded- protein response pathway on protein production in the yeast Saccharomyces cerevisiae

21 January 2018

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The response to unfolded protein is involved in osmotolerance of Pichia pastoris.

21 January 2018

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Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

Isolation and expression of recombinant antibody fragments to the biological warfare pathogen Brucella melitensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. I. Increased functional expression of antibody fragments with and without cis-prolines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Chaperone-assisted folding of a single-chain antibody in a reconstituted translation system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Functional expression of single-chain Fv antibody in the cytoplasm of Escherichia coli by thioredoxin fusion and co-expression of molecular chaperones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Production of a functional catalytic antibody ScFv-NusA fusion protein in bacterial cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

A scFv antibody mutant isolated in a genetic screen for improved export via the twin arginine transporter pathway exhibits faster folding

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

APEx 2-hybrid, a quantitative protein-protein interaction assay for antibody discovery and engineering

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

High volumetric yields of functional dimeric miniantibodies in Escherichia coli, using an optimized expression vector and high-cell-density fermentation under non-limited growth conditions.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

High level Escherichia coli expression and production of a bivalent humanized antibody fragment

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Enhancing the secretory yields of leech carboxypeptidase inhibitor in Escherichia coli: influence of trigger factor and signal recognition particle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Proteomic profiling of recombinant Escherichia coli in high-cell-density fermentations for improved production of an antibody fragment biopharmaceutical

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Production of correctly folded Fab antibody fragment in the cytoplasm of Escherichia coli trxB gor mutants via the coexpression of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Engineering antibody fragments to fold in the absence of disulfide bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

Optimized expression of full-length IgG1 antibody in a common E. coli strain

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Functional production and characterization of a fibrin-specific single-chain antibody fragment from Bacillus subtilis: effects of molecular chaperones and a wall-bound protease on antibody fragment production.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201000381

Production of recombinant antibody fragments in Bacillus megaterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Development of cell-free protein synthesis platforms for disulfide bonded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Improvements in the cell-free production of functional antibodies using cell extract from protease-deficient Escherichia coli mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

An optimized fermentation process for high-level production of a single-chain Fv antibody fragment in Pichia pastoris.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Oxygen-limited control of methanol uptake for improved production of a single-chain antibody fragment with recombinant Pichia pastoris.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Production of single-chain variable fragment antibody (scFv) in fed-batch and continuous culture of Pichia pastoris by two different methanol feeding methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Identification of framework residues in a secreted recombinant antibody fragment that control production level and localization in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Broad-host-range plasmid pJB658 can be used for industrial-level production of a secreted host-toxic single-chain antibody fragment in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

Efficient production of single-chain Fv antibody possessing rare codon linkers in fed-batch fermentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201000381

21 January 2018

Identifiers

DOI

10.1002/BIOT.201000381

1 reference

23 August 2017

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