Hedgehog signaling and therapeutics in pancreatic cancer (Q37824127)

23 August 2017

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title

Hedgehog signaling and therapeutics in pancreatic cancer (English)

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23 August 2017

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Fergal C Kelleher

1

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PubMed ID

21186299

23 August 2017

language of work or name

English

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publication date

24 December 2010

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23 August 2017

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23 August 2017

32

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23 August 2017

4

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23 August 2017

445-451

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Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis

23 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

The hedgehog signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Targeting Hedgehog--a cancer stem cell pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

The hedgehog pathway and neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Sonic hedgehog promotes desmoplasia in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Identification of pancreatic cancer stem cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

A multispecialty approach to the diagnosis and management of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Locally advanced pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Arterial and venous resection for pancreatic adenocarcinoma: operative and long-term outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Stromal depletion goes on trial in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

Treatment of Locally Advanced Pancreatic Cancer in the Real World: Population-Based Practices and Effectiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ280

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGQ280

1 reference

23 August 2017

1 reference

PubMed ID

21186299