Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (Q37606286)

21 August 2017

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title

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (English)

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21 August 2017

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Bin-Bing S Zhou

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21 August 2017

Haiying Zhang

2

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21 August 2017

Marc Damelin

3

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21 August 2017

Kenneth G Geles

4

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21 August 2017

Justin C Grindley

5

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21 August 2017

Peter B Dirks

6

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21 August 2017

1 October 2009

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Nature Reviews Drug Discovery

21 August 2017

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21 August 2017

8

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21 August 2017

806-823

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21 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd2137

21 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

31 March 2020

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31 March 2020

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

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31 March 2020

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31 March 2020

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31 March 2020

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PML targeting eradicates quiescent leukaemia-initiating cells

31 March 2020

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PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

31 March 2020

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

31 March 2020

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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

31 March 2020

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Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

31 March 2020

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Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

31 March 2020

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

31 March 2020

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A distinct "side population" of cells with high drug efflux capacity in human tumor cells

31 March 2020

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Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic

31 March 2020

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Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

31 March 2020

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Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

31 March 2020

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

31 March 2020

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Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

31 March 2020

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Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

31 March 2020

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

31 March 2020

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High-throughput analysis of signals regulating stem cell fate and function

31 March 2020

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

31 March 2020

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Notch signalling regulates stem cell numbers in vitro and in vivo

31 March 2020

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Low O2 tensions and the prevention of differentiation of hES cells

31 March 2020

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Self-renewal of embryonic stem cells by a small molecule

31 March 2020

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High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells

31 March 2020

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High-throughput identification of genes promoting neuron formation and lineage choice in mouse embryonic stem cells

31 March 2020

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A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation

31 March 2020

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High-throughput screening for modulators of stem cell differentiation

31 March 2020

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Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates

31 March 2020

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Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

31 March 2020

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

31 March 2020

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The fuzzy math of solid tumor stem cells: a perspective.

31 March 2020

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

31 March 2020

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Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells

31 March 2020

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Transplantation of Human Tumors in Nude Mice23

31 March 2020

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Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model

31 March 2020

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In vivo imaging, tracking, and targeting of cancer stem cells

31 March 2020

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Detection of functional haematopoietic stem cell niche using real-time imaging.

31 March 2020

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The prognostic role of a gene signature from tumorigenic breast-cancer cells.

31 March 2020

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Isolation of rare circulating tumour cells in cancer patients by microchip technology

31 March 2020

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

31 March 2020

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CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts.

31 March 2020

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The clonal evolution of tumor cell populations

31 March 2020

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CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

31 March 2020

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Modeling the initiation and progression of human acute leukemia in mice

31 March 2020

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Contributions of human tumor xenografts to anticancer drug development

31 March 2020

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Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis

31 March 2020

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12 December 2020

Stem cells: the real culprits in cancer?

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12 December 2020

High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase.

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12 December 2020

Branching morphogenesis of the lung: new models for a classical problem

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12 December 2020

Beyond DNA cross-linking: history and prospects of DNA-targeted cancer treatment--fifteenth Bruce F. Cain Memorial Award Lecture.

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12 December 2020

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

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12 December 2020

Identification of a cancer stem cell in human brain tumors

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12 December 2020

Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity

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12 December 2020

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia.

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12 December 2020

Comment on "Tumor growth need not be driven by rare cancer stem cells".

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12 December 2020

Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

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12 December 2020

Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo.

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12 December 2020

Identifiers

DOI

10.1038/NRD2137

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Dimensions Publication ID

21 August 2017

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