Genetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents (Q37830057)

24 August 2017

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title

Genetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents (English)

1 reference

24 August 2017

Erika K Pollex

1

1 reference

PubMed ID

21247371

24 August 2017

Janine R Hutson

series ordinal

2

1 reference

PubMed ID

21247371

24 August 2017

language of work or name

English

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publication date

20 January 2011

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Expert Opinion on Drug Metabolism & Toxicology

24 August 2017

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24 August 2017

7

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24 August 2017

3

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24 August 2017

325-339

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P-glycoprotein in the placenta: expression, localization, regulation and function.

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Trends in deliveries, prenatal care, and obstetrical complications in women with pregestational diabetes: a population-based study in Ontario, Canada, 1996-2001.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999-2005.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Role of MDR1 and MRP1 in trophoblast cells, elucidated using retroviral gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional role of P-glycoprotein in the human blood-placental barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Role of P-glycoprotein in transplacental transfer of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Genetic variation in the ATP-binding Cassette Transporter gene ABCG2 (BCRP) in a Swedish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Basal Membrane Localization of MRP1 in Human Placental Trophoblast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Expression in human trophoblast and choriocarcinoma cell lines, BeWo, Jeg-3 and JAr of genes involved in the hepatobiliary-like excretory function of the placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Impact of OATP transporters on pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional analysis of organic cation transporter 3 expressed in human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional variants of OCTN cation transporter genes are associated with Crohn disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Clinical pharmacokinetics of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Placental passage of metformin in women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Pharmacokinetics of metformin during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

SLCO1B1 polymorphism and oral antidiabetic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

The role of placental breast cancer resistance protein in the efflux of glyburide across the human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Case series of rosiglitazone used during the first trimester of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Placental transfer of rosiglitazone in the first trimester of human pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Use of repaglinide on a pregnant woman during embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Effect of SLCO1B1 genetic polymorphism on the pharmacokinetics of nateglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

In acute leukemia, the polymorphism −211C>T in the promoter region of the multidrug resistance-associated protein 3 (MRP3) does not determine the expression level of the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

Placental transfer of quetiapine in relation to P-glycoprotein activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.553188

10.1517/17425255.2011.553188

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21247371