Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance (Q37846585)

24 August 2017

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title

Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance (English)

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Pablo Blanco Martínez de Morentín

24 August 2017

author

Pablo Blanco Martínez de Morentin

1

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Miguel López

Miguel López

8

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Manuel Tena-Sempere

Manuel Tena-Sempere

7

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Antonio Vidal-Puig

Antonio Vidal-Puig

6

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author name string

Carmen R González

2

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24 August 2017

Asisk K Saha

3

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24 August 2017

Luís Martins

4

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24 August 2017

Carlos Diéguez

5

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24 August 2017

publication date

1 September 2011

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Reviews in Endocrine and Metabolic Disorders

24 August 2017

published in

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24 August 2017

volume

12

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24 August 2017

issue

3

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24 August 2017

page(s)

127-140

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A war on obesity, not the obese

24 August 2017

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21 January 2018

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The AMP-activated protein kinase cascade--a unifying system for energy control

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21 January 2018

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21 January 2018

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21 January 2018

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

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A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

21 January 2018

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KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

21 January 2018

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

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Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

21 January 2018

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

21 January 2018

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Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

21 January 2018

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Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Central nervous system control of food intake and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Neurobiology of feeding and energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Peripheral tissue-brain interactions in the regulation of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

AMP-activated protein kinase plays a role in the control of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Regulation of hypothalamic malonyl-CoA by central glucose and leptin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic AMP-activated protein kinase regulates glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Retracted: Central Exercise Action Increases the AMPK and mTOR Response to Leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Post-prandial decrease of circulating human ghrelin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin enhances appetite and increases food intake in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

A role for ghrelin in the central regulation of feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin induces adiposity in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin action in the brain controls adipocyte metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Uncoupling protein-2 decreases the lipogenic actions of ghrelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Absence of ghrelin protects against early-onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Mice lacking ghrelin receptors resist the development of diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin stimulates gastric acid secretion and motility in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin causes hyperphagia and obesity in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic CaMKK2 contributes to the regulation of energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

AMP-activated protein kinase signaling in metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Role of resistin in diet-induced hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Brain SIRT1: anatomical distribution and regulation by energy availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic Sirt1 regulates food intake in a rodent model system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Hypothalamic mTOR signaling regulates food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Regulation of food intake through hypothalamic signaling networks involving mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Unexpected evidence for active brown adipose tissue in adult humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Cold-activated brown adipose tissue in healthy men

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Identification and importance of brown adipose tissue in adult humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Functional brown adipose tissue in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

21 January 2018

How does an axon grow?

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-011-9165-5

Gateway to the metabolic syndrome

21 January 2018

1 reference

12 December 2020

Ghrelin strongly stimulates growth hormone release in humans

1 reference

12 December 2020

Metformin activates AMP kinase through inhibition of AMP deaminase

1 reference

12 December 2020

Ghrelin-induced growth hormone secretion in humans

1 reference

12 December 2020

The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function

1 reference

12 December 2020

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

1 reference

12 December 2020

Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo

1 reference

12 December 2020

Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet

1 reference

12 December 2020

10.1007/S11154-011-9165-5

Identifiers

DOI

1 reference

24 August 2017

1 reference