Nrf2: control of sensitivity to carcinogens (Q37849195)

24 August 2017

1 reference

title

Nrf2: control of sensitivity to carcinogens (English)

1 reference

24 August 2017

Stephen L Slocum

1

1 reference

24 August 2017

Thomas W Kensler

series ordinal

2

1 reference

24 August 2017

publication date

3 March 2011

1 reference

24 August 2017

published in

Archives of Toxicology

1 reference

24 August 2017

volume

85

1 reference

24 August 2017

issue

4

1 reference

24 August 2017

page(s)

273-284

1 reference

https://scigraph.springernature.com/pub.10.1007/s00204-011-0675-4

24 August 2017

exact match

0 references

cites work

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

The role of Keap1 in cellular protective responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

High levels of Nrf2 determine chemoresistance in type II endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2: friend or foe for chemoprevention?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Regulation of notch1 signaling by nrf2: implications for tissue regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Carcinogenic effects of low dietary levels of aflatoxin B1 in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Nrf2 as a target for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0675-4

10.1007/S00204-011-0675-4

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference