α2C-adrenoceptor modulators: a patent review (Q37854049)

24 August 2017

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title

α2C-adrenoceptor modulators: a patent review (English)

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24 August 2017

Wilma Quaglia

1

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24 August 2017

Fabio Del Bello

2

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24 August 2017

Mario Giannella

3

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24 August 2017

Alessandro Piergentili

4

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24 August 2017

Maria Pigini

5

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24 August 2017

language of work or name

English

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publication date

1 April 2011

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Expert Opinion on Therapeutic Patents

24 August 2017

published in

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24 August 2017

volume

21

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24 August 2017

issue

4

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24 August 2017

page(s)

455-481

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Differentiation of Receptor Systems activated by Sympathomimetic Amines

24 August 2017

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A functional basis for classification of α-adrenergic receptors

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Classification of alpha 1-adrenoceptor subtypes

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.alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. Part 1. Molecular Biology and Adrenoceptor Subclassification

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The use of constitutively active GPCRs in drug discovery and functional genomics

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Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

21 January 2018

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Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype

21 January 2018

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Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

21 January 2018

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Molecular characterization of a rat alpha 2B-adrenergic receptor

21 January 2018

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Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16.

21 January 2018

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Pharmacological characteristics of alpha-2 adrenergic receptor subtypes

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alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actions

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Central hypotensive effects of the alpha2a-adrenergic receptor subtype

21 January 2018

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Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough

21 January 2018

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Different roles of alpha2-adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat

21 January 2018

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Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice

21 January 2018

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Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission

21 January 2018

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Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice

21 January 2018

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Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models.

21 January 2018

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Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice

21 January 2018

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Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.

21 January 2018

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The vasculopathy of Raynaud's phenomenon and scleroderma

21 January 2018

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Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns.

21 January 2018

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Role of alpha2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alpha2C-adrenoceptor gene

21 January 2018

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Insights from in vivo modification of adrenergic receptor gene expression

21 January 2018

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D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype

21 January 2018

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Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models

21 January 2018

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alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy

21 January 2018

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The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma

21 January 2018

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Pharmacology and physiology of human adrenergic receptor polymorphisms

21 January 2018

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Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure

21 January 2018

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Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor

21 January 2018

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Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure

21 January 2018

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A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors

21 January 2018

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Clinical uses of alpha2 -adrenergic agonists

21 January 2018

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Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs

21 January 2018

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Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block

21 January 2018

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Hemodynamic and respiratory changes following dexmedetomidine administration during general anesthesia: sevoflurane vs desflurane

21 January 2018

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Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children.

21 January 2018

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Dexmedetomidine as a total intravenous anesthetic in infants

21 January 2018

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Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine

21 January 2018

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The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype

21 January 2018

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Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist.

21 January 2018

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Peripheral suppression of arthritic pain by intraarticular fadolmidine, an alpha 2-adrenoceptor agonist, in the rat.

21 January 2018

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Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs

21 January 2018

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High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells

21 January 2018

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Receptor reserve analysis of the human alpha(2C)-adrenoceptor using

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli.

21 January 2018

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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

21 January 2018

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Agonists and antagonists targeting the different alpha2-adrenoceptor subtypes

21 January 2018

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Presynaptic alpha 2-adrenoceptors mediating inhibition of noradrenaline and 5-hydroxytryptamine release in rat cerebral cortex: further characterization as different alpha 2-adrenoceptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

Rigid Analogues of the α2-Adrenergic Blocker Atipamezole: Small Changes, Big Consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.565333

10.1517/13543776.2011.565333

21 January 2018

Identifiers

DOI

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24 August 2017

1 reference