Approaches to target the genome and its epigenome in cancer (Q37855866)

24 August 2017

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title

Approaches to target the genome and its epigenome in cancer (English)

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24 August 2017

Nadine Chapman-Rothe

1

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PubMed ID

21426061

24 August 2017

Robert Brown

series ordinal

2

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24 August 2017

1 November 2009

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Future Medicinal Chemistry

24 August 2017

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24 August 2017

1

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24 August 2017

8

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24 August 2017

1481-1495

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https://api.crossref.org/works/10.4155%2FFMC.09.105

24 August 2017

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Epigenetics: a landscape takes shape

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

X inactivation, differentiation, and DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

MeCP2 and other methyl-CpG binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

DNA methylation and environmental exposures in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

A DNA methylation-based switch generates bistable gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

The epigenomics of cancer

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.105

DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

DNA methylation and gene silencing in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

DNA methyltransferase inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

The promises and pitfalls of epigenetic therapies in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Deficiency of Mbd2 attenuates Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Duration of nuclear NF-kappaB action regulated by reversible acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Regulation of E2F1 activity by acetylation

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.105

Deacetylation of p53 modulates its effect on cell growth and apoptosis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.105

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Targeting the mTOR signaling network in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Small silencing RNAs: state-of-the-art

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

MicroRNA-directed transcriptional gene silencing in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

The promises and pitfalls of RNA-interference-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Improved nuclear localization of DNA-binding polyamides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Accessibility of Nuclear Chromatin by DNA Binding Polyamides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Chromatin opening of DNA satellites by targeted sequence-specific drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Inhibition of transcription at a coding sequence by alkylating polyamide

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Arresting cancer proliferation by small-molecule gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Rapid, high-throughput engineering of sequence-specific zinc finger DNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Krüppel-associated boxes are potent transcriptional repression domains

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

The control of histone lysine methylation in epigenetic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.105

21 January 2018

Identifiers

DOI

10.4155/FMC.09.105

1 reference

24 August 2017

1 reference

PubMed ID

21426061