p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress (Q37867129)

24 August 2017

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title

p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress (English)

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24 August 2017

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Sebastio Perrini

3

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Francesco Giorgino

object named as

Francesco Giorgino

series ordinal

5

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Luigi Laviola

series ordinal

4

object named as

Luigi Laviola

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24 August 2017

1

Annalisa Natalicchio

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24 August 2017

Federica Tortosa

2

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24 August 2017

21 April 2011

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Archives of Physiology and Biochemistry

24 August 2017

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24 August 2017

117

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24 August 2017

3

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24 August 2017

116-124

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Annexin 1 regulates cell proliferation by disruption of cell morphology and inhibition of cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal

24 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Stem cells and the regeneration of the aging cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The role of p66Shc deletion in age-associated arterial dysfunction and disease states.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Effects of EGF, bFGF, NGF and PDGF(bb) on cell proliferative, migratory and invasive capacities of human brain-tumour biopsies in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Deletion of p66shc gene protects against age-related endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Mitochondrial Generation of Reactive Oxygen Species and its Role in Aerobic Life

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Hyperketonemia increases tumor necrosis factor-alpha secretion in cultured U937 monocytes and Type 1 diabetic patients and is apparently mediated by oxidative stress and cAMP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Regulation of cell motility by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Role of the life span determinant P66(shcA) in ethanol-induced liver damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

c-Jun N-terminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Evolution of Shc functions from nematode to human

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Oxidant stress in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Actin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

A model for p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Signaling via Shc family adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The role of mitochondrial oxidative stress in aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Cell motility, invasion, and malignancy induced by overexpression of K-FGF or bFGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Distinct mechanisms of taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

p66ShcA modulates tissue response to hindlimb ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.562513

10.3109/13813455.2011.562513

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21506908