Polycomb group proteins in hematopoietic stem cell aging and malignancies (Q37869366)

24 August 2017

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title

Polycomb group proteins in hematopoietic stem cell aging and malignancies (English)

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24 August 2017

Karin Klauke

1

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24 August 2017

Gerald de Haan

series ordinal

2

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24 August 2017

publication date

27 April 2011

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International Journal of Hematology

24 August 2017

published in

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24 August 2017

volume

94

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24 August 2017

issue

1

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24 August 2017

page(s)

11-23

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A direct measurement of the radiation sensitivity of normal mouse bone marrow cells

24 August 2017

cites work

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Epigenetics: a landscape takes shape

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Polycomb silencers control cell fate, development and cancer

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Aging mice show a decreasing correlation of gene expression within genetic modules

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21 January 2018

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Epigenetic gene silencing in cancer: the DNA hypermethylome

21 January 2018

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21 January 2018

Epigenetics in cancer

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A gene complex controlling segmentation in Drosophila

21 January 2018

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

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Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective

21 January 2018

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

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Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

21 January 2018

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

21 January 2018

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Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

21 January 2018

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Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

21 January 2018

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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

21 January 2018

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Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin

21 January 2018

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Hierarchical recruitment of polycomb group silencing complexes

21 January 2018

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

21 January 2018

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

21 January 2018

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Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation

21 January 2018

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

21 January 2018

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PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos

21 January 2018

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Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

21 January 2018

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Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences

21 January 2018

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Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

21 January 2018

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Polycomb group proteins: navigators of lineage pathways led astray in cancer

21 January 2018

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Long noncoding RNA as modular scaffold of histone modification complexes

21 January 2018

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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

21 January 2018

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Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells

21 January 2018

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Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

21 January 2018

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Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

21 January 2018

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Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.

21 January 2018

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells

21 January 2018

1 reference

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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

21 January 2018

1 reference

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Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Modern genome-wide genetic approaches to reveal intrinsic properties of stem cells

21 January 2018

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Genetical genomics: the added value from segregation.

21 January 2018

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Intrinsic and Extrinsic Control of Hemopoietic Stem Cell Numbers: Mapping of a Stem Cell Gene

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice

21 January 2018

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Genetic control of stem-cell properties and stem cells in aging

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb group protein ezh2 controls actin polymerization and cell signaling.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

21 January 2018

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Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity

21 January 2018

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Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

21 January 2018

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The regulation of INK4/ARF in cancer and aging

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The INK4a/ARF network in tumour suppression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

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Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

21 January 2018

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

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Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus

21 January 2018

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p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

21 January 2018

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Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

21 January 2018

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BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The age distribution of cancer and a multi-stage theory of carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

21 January 2018

Acute myeloid leukemia

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Karyotype and age in acute myeloid leukemia. Are they linked?

21 January 2018

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A new theory on cancer-inducing mechanism

21 January 2018

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Normal Production of Erythrocytes by Mouse Marrow Continuous for 73 Months

21 January 2018

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Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Unique molecular and cellular features of acute myelogenous leukemia stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The molecular signature of oncofusion proteins in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The biology and therapy of adult acute lymphoblastic leukemia

21 January 2018

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Prevalence of t(12;21)[ETV6-RUNX1]-positive cells in healthy neonates.

21 January 2018

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t(11;14)-positive clones can persist over a long period of time in the peripheral blood of healthy individuals.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Chromosome translocations and covert leukemic clones are generated during normal fetal development

21 January 2018

1 reference

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Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals

21 January 2018

1 reference

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The history of cancer epigenetics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Cross-talk between aging and cancer: the epigenetic language

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Global histone modification patterns predict risk of prostate cancer recurrence

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb proteins in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Role of the chromobox protein CBX7 in lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0857-0

Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays

21 January 2018

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Modification of Morphine Withdrawal by Drugs interacting with Humoral Mechanisms: Some Contradictions and their Interpretation

21 January 2018

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Early repair processes in marrow cells irradiated and proliferating in vivo

21 January 2018

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12 December 2020

HOW MANY CELL-GENERATIONS?

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12 December 2020

A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton

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12 December 2020

Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span

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12 December 2020

Autonomous behavior of hematopoietic stem cells

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12 December 2020

Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice

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12 December 2020

DNA methylation and cancer

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12 December 2020

Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1

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12 December 2020

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.

1 reference

12 December 2020

Dynamic changes in mouse hematopoietic stem cell numbers during aging.

1 reference

12 December 2020

REPAIR PROCESSES IN IRRADIATED MOUSE HEMATOPOIETIC TISSUE

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12 December 2020

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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12 December 2020

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

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12 December 2020

Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27 beta DNA probe

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12 December 2020

Stage-specific expression of polycomb group genes in human bone marrow cells

1 reference

12 December 2020

Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis

1 reference

12 December 2020

Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity.

1 reference

12 December 2020

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas

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12 December 2020

Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging

1 reference

12 December 2020

Decline in bone marrow proliferative capacity as a function of age

1 reference

12 December 2020

Mechanisms of polycomb gene silencing: knowns and unknowns

1 reference

12 December 2020

Heterochromatin islands and their dynamic reorganization: a hypothesis for three distinctive features of cellular aging

1 reference

12 December 2020

Genetic control of hematopoietic stem cell frequency in mice is mostly cell autonomous

1 reference

12 December 2020

Normal Function of Transplanted Mouse Erythrocyte Precursors for 21 Months beyond Donor Life Spans

1 reference

12 December 2020

10.1007/S12185-011-0857-0

Identifiers

DOI

1 reference

24 August 2017

1 reference