Polycomb group proteins: navigators of lineage pathways led astray in cancer (Q37620148)

21 August 2017

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title

Polycomb group proteins: navigators of lineage pathways led astray in cancer (English)

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21 August 2017

2

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21 August 2017

Adrian P Bracken

1

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language of work or name

English

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publication date

1 November 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

773-784

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21 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrc2736

21 August 2017

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The polycomb group protein Suz12 is required for embryonic stem cell differentiation

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Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

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Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

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Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

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Polycomb CBX7 has a unifying role in cellular lifespan

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

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Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

31 March 2020

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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

31 March 2020

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Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

31 March 2020

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Tumor suppression by Ink4a-Arf: progress and puzzles

31 March 2020

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The Polycomb group protein EZH2 directly controls DNA methylation

31 March 2020

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Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation

31 March 2020

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Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome

31 March 2020

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors

31 March 2020

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EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

31 March 2020

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

31 March 2020

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

31 March 2020

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The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer

31 March 2020

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Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma.

31 March 2020

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The polycomb group protein EZH2 is involved in progression of prostate cancer

31 March 2020

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High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma.

31 March 2020

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The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

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Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

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Polycomb-group genes as regulators of mammalian lymphopoiesis

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Stability and dynamics of polycomb target sites in Drosophila development.

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The RUNX genes: gain or loss of function in cancer

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The emerging roles of forkhead box (Fox) proteins in cancer

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Modulating Hox gene functions during animal body patterning

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A PANorama of PAX genes in cancer and development

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The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

31 March 2020

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RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1

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Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling

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Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.

31 March 2020

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The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

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Ikaros represses the transcriptional response to Notch signaling in T-cell development

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Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation.

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Long non-coding RNAs: insights into functions

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Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation

31 March 2020

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

31 March 2020

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Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos

31 March 2020

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Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

31 March 2020

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Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

31 March 2020

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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

31 March 2020

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Structured non-coding RNAs and the RNP Renaissance

31 March 2020

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A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes.

31 March 2020

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Chromodomains are protein-RNA interaction modules

31 March 2020

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Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin

31 March 2020

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Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha

31 March 2020

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

31 March 2020

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

31 March 2020

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PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

31 March 2020

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Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

31 March 2020

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Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding

31 March 2020

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Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

31 March 2020

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MYB function in normal and cancer cells

31 March 2020

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Lineage dependency and lineage-survival oncogenes in human cancer

31 March 2020

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Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia

31 March 2020

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GATA-3 and the regulation of the mammary luminal cell fate

31 March 2020

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The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control

31 March 2020

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BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

31 March 2020

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Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

31 March 2020

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Oct-3/4 is a dose-dependent oncogenic fate determinant

31 March 2020

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Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues

31 March 2020

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A stem cell molecular signature

31 March 2020

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Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

31 March 2020

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Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

31 March 2020

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Pax3 functions at a nodal point in melanocyte stem cell differentiation

31 March 2020

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Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal

31 March 2020

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31 March 2020

Plzf pushes stem cells.

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

31 March 2020

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

31 March 2020

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Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

31 March 2020

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Multiple roles for Sox2 in the developing and adult mouse trachea

31 March 2020

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Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers

31 March 2020

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Haematopoietic cell-fate decisions, chromatin regulation and ikaros

31 March 2020

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

31 March 2020

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Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.

31 March 2020

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Luminal cells GATA have it

31 March 2020

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Nuclear reprogramming in cells

31 March 2020

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Epigenetic reprogramming and induced pluripotency

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

31 March 2020

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Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Regulatory networks in embryo-derived pluripotent stem cells

31 March 2020

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Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis

31 March 2020

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Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

31 March 2020

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A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas

31 March 2020

1 reference

RNA-Seq: a revolutionary tool for transcriptomics

31 March 2020

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Extreme makeover: converting one cell into another

31 March 2020

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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

31 March 2020

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Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors.

31 March 2020

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Stepwise reprogramming of B cells into macrophages

31 March 2020

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In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

31 March 2020

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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.

31 March 2020

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The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis

31 March 2020

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Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer

31 March 2020

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NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

31 March 2020

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The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells

31 March 2020

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Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

31 March 2020

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

31 March 2020

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MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A

31 March 2020

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Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis

31 March 2020

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Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

31 March 2020

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

31 March 2020

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Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

31 March 2020

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Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

31 March 2020

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

31 March 2020

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E protein silencing by the leukemogenic AML1-ETO fusion protein

31 March 2020

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A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

31 March 2020

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Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.

31 March 2020

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TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

31 March 2020

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

31 March 2020

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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

31 March 2020

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Characterizing the cancer genome in lung adenocarcinoma

31 March 2020

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Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice

31 March 2020

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CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer.

31 March 2020

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Homeosis and intestinal tumours in Cdx2 mutant mice

31 March 2020

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CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene.

31 March 2020

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

31 March 2020

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Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

31 March 2020

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FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene

31 March 2020

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GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland

31 March 2020

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Mutation of GATA3 in human breast tumors

31 March 2020

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CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis

31 March 2020

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Compromised HOXA5 function can limit p53 expression in human breast tumours

31 March 2020

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The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control

31 March 2020

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Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas.

31 March 2020

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KLF6, a candidate tumor suppressor gene mutated in prostate cancer

31 March 2020

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Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.

31 March 2020

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KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3

31 March 2020

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia

31 March 2020

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

31 March 2020

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Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

31 March 2020

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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

31 March 2020

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Causal relationship between the loss of RUNX3 expression and gastric cancer

31 March 2020

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RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

31 March 2020

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

31 March 2020

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Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

31 March 2020

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An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

31 March 2020

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A tumor suppressor and oncogene: the WT1 story.

31 March 2020

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T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes

31 March 2020

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12 December 2020

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.

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12 December 2020

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia

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12 December 2020

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

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12 December 2020

Chromosome 13q deletion mapping in head and neck squamous cell carcinomas: identification of two distinct regions of preferential loss

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12 December 2020

Induction of p21 by the Wilms' tumor suppressor gene WT1

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12 December 2020

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas

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12 December 2020

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

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12 December 2020

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

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12 December 2020

Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors

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12 December 2020

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

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12 December 2020

Genomic amplification of orthodenticle homologue 2 in medulloblastomas

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12 December 2020

Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas

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12 December 2020

Identifiers

DOI

10.1038/NRC2736

1 reference

PubMed ID

19851313

Dimensions Publication ID

21 August 2017

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1 reference

PubMed ID

19851313