The insider's guide to leukocyte integrin signalling and function (Q37877543)

24 August 2017

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title

The insider's guide to leukocyte integrin signalling and function (English)

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24 August 2017

Nancy Hogg

1

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24 August 2017

Irene Patzak

series ordinal

2

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24 August 2017

Frances Willenbrock

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3

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24 August 2017

language of work or name

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20 May 2011

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Nature Reviews Immunology

24 August 2017

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24 August 2017

11

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24 August 2017

416-426

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24 August 2017

6

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Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies

24 August 2017

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The ins and outs of leukocyte integrin signaling

21 January 2018

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The tail of integrins, talin, and kindlins

21 January 2018

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21 January 2018

Integrins in immunity

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The cellular context of T cell signaling

21 January 2018

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Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

21 January 2018

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Rapid leukocyte migration by integrin-independent flowing and squeezing

21 January 2018

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LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo

21 January 2018

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Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

21 January 2018

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Structural basis of integrin regulation and signaling

21 January 2018

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Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells

21 January 2018

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Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bonds

21 January 2018

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Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

21 January 2018

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

21 January 2018

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The phosphotyrosine binding-like domain of talin activates integrins

21 January 2018

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RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

21 January 2018

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

21 January 2018

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The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1).

21 January 2018

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Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

21 January 2018

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21 January 2018

Rolling cell adhesion

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Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state

21 January 2018

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Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1

21 January 2018

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Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion

21 January 2018

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Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

21 January 2018

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The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.

21 January 2018

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Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane

21 January 2018

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

21 January 2018

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Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

21 January 2018

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Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.

21 January 2018

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Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

21 January 2018

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T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes

21 January 2018

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

21 January 2018

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RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation

21 January 2018

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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

21 January 2018

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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

21 January 2018

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Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

21 January 2018

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Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module.

21 January 2018

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Critical role of PIP5KI{gamma}87 in InsP3-mediated Ca(2+) signaling

21 January 2018

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Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

21 January 2018

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The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

21 January 2018

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Structural basis for the autoinhibition of talin in regulating integrin activation

21 January 2018

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

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Chemokine-induced Zap70 kinase-mediated dissociation of the Vav1-talin complex activates alpha4beta1 integrin for T cell adhesion.

21 January 2018

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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

21 January 2018

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A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

21 January 2018

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LAD-1/variant syndrome is caused by mutations in FERMT3.

21 January 2018

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Kindlin-3: a new gene involved in the pathogenesis of LAD-III.

21 January 2018

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Kindlins: essential regulators of integrin signalling and cell-matrix adhesion

21 January 2018

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The molecular basis of filamin binding to integrins and competition with talin

21 January 2018

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Structural basis of the migfilin-filamin interaction and competition with integrin beta tails

21 January 2018

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Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

21 January 2018

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Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

21 January 2018

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Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.

21 January 2018

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

21 January 2018

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Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

21 January 2018

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21 January 2018

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Recreation of the terminal events in physiological integrin activation

21 January 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

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A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.

21 January 2018

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Structural basis of integrin activation by talin

21 January 2018

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Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners

21 January 2018

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Kindlin-3 is essential for integrin activation and platelet aggregation

21 January 2018

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Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

21 January 2018

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Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell

21 January 2018

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Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

21 January 2018

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T-cell receptor signaling to integrins

21 January 2018

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Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.

21 January 2018

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The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells

21 January 2018

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The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation

21 January 2018

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Role for ADAP in shear flow-induced platelet mechanotransduction

21 January 2018

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Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

21 January 2018

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Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

21 January 2018

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PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling

21 January 2018

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E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling

21 January 2018

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Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

21 January 2018

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Genetic etiologies of leukocyte adhesion defects

21 January 2018

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Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

21 January 2018

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A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections.

21 January 2018

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Importance of integrin LFA-1 deactivation for the generation of immune responses

21 January 2018

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Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes

21 January 2018

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Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.

21 January 2018

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Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes

21 January 2018

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PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells

21 January 2018

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Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation

21 January 2018

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Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.

21 January 2018

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

21 January 2018

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The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.

21 January 2018

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Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.

21 January 2018

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Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells

21 January 2018

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Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell Memory

21 January 2018

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Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

21 January 2018

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The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

31 March 2020

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The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in susta

31 March 2020

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Talin1 regulates TCR-mediated LFA-1 function

31 March 2020

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Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling

31 March 2020

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RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes

31 March 2020

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T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76

31 March 2020

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LFA-1 to LFA-1 signals involve zeta-associated protein-70 (ZAP-70) tyrosine kinase: relevance for invasion and migration of a T cell hybridoma

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21597477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21597477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Leukocyte adhesion deficiency-III in an African-American patient

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21597477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2986

1 reference

24 August 2017

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