Toll-like receptor-4 antagonist eritoran tetrasodium for severe sepsis (Q37879190)

24 August 2017

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title

Toll-like receptor-4 antagonist eritoran tetrasodium for severe sepsis (English)

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24 August 2017

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Mark Tidswell

1

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PubMed ID

21609262

24 August 2017

Steven P LaRosa

series ordinal

2

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24 August 2017

1 May 2011

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Expert Review of Anti-infective Therapy

24 August 2017

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24 August 2017

9

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24 August 2017

5

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24 August 2017

507-520

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Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock

24 August 2017

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Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study.

21 January 2018

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Combination therapy with polymyxin B-immobilized fibre haemoperfusion and teicoplanin for sepsis due to methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

Molecular biology of inflammation and sepsis: a primer

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

21 January 2018

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Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa.

21 January 2018

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

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Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin

21 January 2018

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Innate immune sensing and its roots: the story of endotoxin

21 January 2018

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

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Toll-like receptor signalling

21 January 2018

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

21 January 2018

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Bench-to-bedside review: Cytopathic hypoxia

21 January 2018

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Hmgb-1 as a therapeutic target for infectious and inflammatory disorders.

21 January 2018

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Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock

21 January 2018

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The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

21 January 2018

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Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis

21 January 2018

1 reference

Therapeutic approaches to superantigen‐based diseases: a review

21 January 2018

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Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis.

21 January 2018

1 reference

Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

21 January 2018

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21 January 2018

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Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis

21 January 2018

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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

21 January 2018

1 reference

Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.

21 January 2018

1 reference

The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim

21 January 2018

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Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

21 January 2018

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Structural analysis of the nontoxic lipid A of Rhodobacter capsulatus 37b4.

21 January 2018

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E5531, a pure endotoxin antagonist of high potency

21 January 2018

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Consequences of interaction of a lipophilic endotoxin antagonist with plasma lipoproteins

21 January 2018

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Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers

21 January 2018

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Inhibition of endotoxin response by synthetic TLR4 antagonists

21 January 2018

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21 January 2018

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Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

21 January 2018

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Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008

21 January 2018

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Early goal-directed therapy in the treatment of severe sepsis and septic shock

21 January 2018

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Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network

21 January 2018

1 reference

Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock

21 January 2018

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Hydrocortisone therapy for patients with septic shock

21 January 2018

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

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Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death

21 January 2018

1 reference

Intensive insulin therapy in critically ill patients

21 January 2018

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Intensive versus conventional glucose control in critically ill patients

21 January 2018

1 reference

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis.

21 January 2018

1 reference

Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli

21 January 2018

1 reference

Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group

21 January 2018

1 reference

Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide

21 January 2018

1 reference

A controlled trial of HA-1A in a canine model of gram-negative septic shock.

21 January 2018

1 reference

The sirens' songs of confirmatory sepsis trials: selection bias and sampling error.

21 January 2018

1 reference

Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: relationship to endotoxin and cytokine levels

21 January 2018

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Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria

21 January 2018

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Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group

21 January 2018

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Bactericidal/permeability-increasing protein--lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia

21 January 2018

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Safety and pharmacokinetics of an endotoxin-binding phospholipid emulsion

21 January 2018

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Neutralization of endotoxin by a phospholipid emulsion in healthy volunteers.

21 January 2018

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Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial

21 January 2018

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Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis.

21 January 2018

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Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors

21 January 2018

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Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review

21 January 2018

1 reference

Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate

21 January 2018

1 reference

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis

21 January 2018

1 reference

Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

21 January 2018

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Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection.

21 January 2018

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Association of the endotoxin antagonist E5564 with high-density lipoproteins in vitro: dependence on low-density and triglyceride-rich lipoprotein concentrations

21 January 2018

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Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia

21 January 2018

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Continuous pharmacodynamic activity of eritoran tetrasodium, a TLR4 antagonist, during intermittent intravenous infusion into normal volunteers

21 January 2018

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Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia

21 January 2018

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APACHE II: a severity of disease classification system

21 January 2018

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TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines

21 January 2018

1 reference

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria

21 January 2018

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Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

21 January 2018

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A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass.

21 January 2018

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TLR4 is essential in acute lung injury induced by unresuscitated hemorrhagic shock.

21 January 2018

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Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

21 January 2018

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Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen

21 January 2018

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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

21 January 2018

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Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice

21 January 2018

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Injury, sepsis, and the regulation of Toll-like receptor responses

21 January 2018

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TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.

21 January 2018

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TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.

21 January 2018

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Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms

21 January 2018

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Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

21 January 2018

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Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling

21 January 2018

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

21 January 2018

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Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

21 January 2018

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Toll-dependent selection of microbial antigens for presentation by dendritic cells

21 January 2018

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CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERI.11.27

1 reference

24 August 2017

1 reference

PubMed ID

21609262