The roles of fascins in health and disease (Q37880684)

24 August 2017

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title

The roles of fascins in health and disease (English)

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24 August 2017

Josephine C Adams

3

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author name string

Yosuke Hashimoto

series ordinal

1

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PubMed ID

21618240

24 August 2017

Dae Joong Kim

series ordinal

2

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24 August 2017

25 May 2011

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24 August 2017

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24 August 2017

224

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24 August 2017

3

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24 August 2017

289-300

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Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all β-trefoil proteins 1 1Edited by J. Thornton

24 August 2017

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Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein

21 January 2018

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Binding of hisactophilin I and II to lipid membranes is controlled by a pH-dependent myristoyl-histidine switch

21 January 2018

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Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling

21 January 2018

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Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility

21 January 2018

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Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin

21 January 2018

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Rac regulates the interaction of fascin with protein kinase C in cell migration

21 January 2018

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Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes

21 January 2018

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Preparation and purification of polymerized actin from sea urchin egg extracts

21 January 2018

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"Malabsorptive" dermatitis herpetiformis. A study with particular regard to biopsy findings of the small intestine (author's transl)

21 January 2018

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Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension

21 January 2018

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Phenotypes of Drosophila brain neurons in primary culture reveal a role for fascin in neurite shape and trajectory.

21 January 2018

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Fascin is required for blood cell migration during Drosophila embryogenesis.

21 January 2018

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Roles for Drosophila melanogaster myosin IB in maintenance of enterocyte brush-border structure and resistance to the bacterial pathogen Pseudomonas entomophila

21 January 2018

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Proper cellular reorganization during Drosophila spermatid individualization depends on actin structures composed of two domains, bundles and meshwork, that are differentially regulated and have different functions

21 January 2018

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Expression of fascin-1, the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis.

21 January 2018

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Fascin expression in human embryonic, fetal, and normal adult tissue

21 January 2018

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Fascin1 is dispensable for mouse development but is favorable for neonatal survival

21 January 2018

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Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42

21 January 2018

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Disruption of the cytoskeleton during Semaphorin 3A induced growth cone collapse correlates with differences in actin organization and associated binding proteins.

21 January 2018

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Effects of UVB on fascin expression in dendritic cells and Langerhans cells

21 January 2018

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Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.

21 January 2018

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MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro

21 January 2018

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The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion

21 January 2018

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Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin

21 January 2018

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Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes

21 January 2018

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Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella

21 January 2018

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Regulation of actin binding and actin bundling activities of fascin by caldesmon coupled with tropomyosin.

21 January 2018

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Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments

21 January 2018

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Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling protein: retinal fascin

21 January 2018

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Retina-specific protein fascin 2 is an actin cross-linker associated with actin bundles in photoreceptor inner segments and calycal processes

21 January 2018

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Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head

21 January 2018

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Analysis of proteomic changes associated with sperm capacitation through the combined use of IPG-strip pre-fractionation followed by RP chromatography LC-MS/MS analysis.

21 January 2018

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Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells

21 January 2018

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The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer

21 January 2018

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Minor expression of fascin-1 gene (FSCN1) in NTera2 cells depleted of CREB-binding protein

21 January 2018

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miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer

21 January 2018

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miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma

21 January 2018

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Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma

21 January 2018

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Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis

21 January 2018

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Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin

21 January 2018

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Cytoplasmic domain of protocadherin-alpha enhances homophilic interactions and recognizes cytoskeletal elements

21 January 2018

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Rab35 controls actin bundling by recruiting fascin as an effector protein.

21 January 2018

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Phosphorylation of human fascin inhibits its actin binding and bundling activities

21 January 2018

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Cell-matrix adhesions differentially regulate fascin phosphorylation

21 January 2018

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Role of fascin in filopodial protrusion

21 January 2018

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Fascins, and their roles in cell structure and function.

21 January 2018

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Actin cross-link assembly and disassembly mechanics for alpha-Actinin and fascin

21 January 2018

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Intrinsic dynamic behavior of fascin in filopodia

21 January 2018

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Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones

21 January 2018

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Functional synergy of actin filament cross-linking proteins

21 January 2018

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The stepping pattern of myosin X is adapted for processive motility on bundled actin

21 January 2018

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A cytoskeletal demolition worker: myosin II acts as an actin depolymerization agent.

21 January 2018

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Unconventional processive mechanics of non-muscle myosin IIB.

21 January 2018

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Formation of filopodia-like bundles in vitro from a dendritic network

21 January 2018

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Mechanism of filopodia initiation by reorganization of a dendritic network

21 January 2018

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Arp2/3 branched actin network mediates filopodia-like bundles formation in vitro.

21 January 2018

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Electron tomography reveals unbranched networks of actin filaments in lamellipodia

21 January 2018

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The filamentous actin cross-linking/bundling activity of mammalian formins.

21 January 2018

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Self-assembly of filopodia-like structures on supported lipid bilayers

21 January 2018

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C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines

21 January 2018

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Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer

21 January 2018

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Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells

21 January 2018

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Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer

21 January 2018

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Effects of small interfering RNAs targeting Fascin on gene expression in oral cancer cells

21 January 2018

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Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines

21 January 2018

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Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro

21 January 2018

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Genes that mediate breast cancer metastasis to lung

21 January 2018

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Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression

21 January 2018

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Migrastatin analogues target fascin to block tumour metastasis

21 January 2018

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Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice

21 January 2018

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The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis

21 January 2018

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Fascin expression in 90 patients with glioblastoma multiforme.

21 January 2018

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The role of fascin in the migration and invasiveness of malignant glioma cells.

21 January 2018

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Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades.

21 January 2018

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Dysregulation of growth factor receptor-bound protein 2 and fascin in hippocampus of mice polytransgenic for chromosome 21 structures

21 January 2018

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Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance

21 January 2018

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Actin-binding protein fascin expression in skin neoplasia

21 January 2018

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Comparative proteomic analysis of mouse melanoma cell line B16, a metastatic descendant B16F10, and B16 overexpressing the metastasis-associated tyrosine phosphatase PRL-3.

21 January 2018

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Autosomal Dominant Macular Degeneration Associated With 208del G Mutation in the FSCN2 Gene

21 January 2018

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The 208delG mutation in FSCN2 does not associate with retinal degeneration in Chinese individuals

21 January 2018

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Targeted disruption of FSCN2 gene induces retinopathy in mice

21 January 2018

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Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa

21 January 2018

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How the genetics of deafness illuminates auditory physiology

21 January 2018

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The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

21 January 2018

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Retinal neurodegeneration in the DBA/2J mouse-a model for ocular hypertension.

21 January 2018

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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

21 January 2018

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The RickA protein of Rickettsia conorii activates the Arp2/3 complex

21 January 2018

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The pH-sensitive actin-binding protein hisactophilin of Dictyostelium exists in two isoforms which both are myristoylated and distributed between plasma membrane and cytoplasm.

21 January 2018

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F actin bundles in Drosophila bristles. I. Two filament cross-links are involved in bundling

21 January 2018

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Filopodia: Complex models for simple rods.

21 January 2018

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Filopodia: molecular architecture and cellular functions

21 January 2018

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A role for syndecan-1 in coupling fascin spike formation by thrombospondin-1

21 January 2018

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Cell-adhesive responses to tenascin-C splice variants involve formation of fascin microspikes

21 January 2018

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Induction of fascin spikes in breast cancer cells by activation of the insulin-like growth factor-I receptor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.2894

1 reference

24 August 2017

1 reference

PubMed ID

21618240