Type 2 diabetes and obesity: genomics and the clinic (Q37885799)

24 August 2017

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title

Type 2 diabetes and obesity: genomics and the clinic (English)

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24 August 2017

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Mark I McCarthy

2

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author name string

Mary E Travers

series ordinal

1

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24 August 2017

7 June 2011

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24 August 2017

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24 August 2017

130

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24 August 2017

41-58

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24 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00439-011-1023-8

24 August 2017

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cites work

FTO genetic variation and association with obesity in West Africans and African Americans

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

21 January 2018

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Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Effect of direct-to-consumer genomewide profiling to assess disease risk

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population

21 January 2018

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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Rare variants create synthetic genome-wide associations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Cause-specific excess deaths associated with underweight, overweight, and obesity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A map of open chromatin in human pancreatic islets

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

The clinical application of genetic testing in type 2 diabetes: a patient and physician survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Fine mapping of the association with obesity at the FTO locus in African-derived populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Predictive testing for complex diseases using multiple genes: fact or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Clinical risk factors, DNA variants, and the development of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genetic and environmental factors in relative body weight and human adiposity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genomics, type 2 diabetes, and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genotype score in addition to common risk factors for prediction of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genomic Priorities and Public Health

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Prevalence of loss-of-function FTO mutations in lean and obese individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Worldwide population differentiation at disease-associated SNPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Pharmacogenetics in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genetic cause of hyperglycaemia and response to treatment in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance--a population-based twin study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

The human obesity gene map: the 2005 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Combined analyses of 20 common obesity susceptibility variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genotype-based risk and pharmacogenetic sampling in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Prospective study of zinc intake and risk of type 2 diabetes in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Common nonsynonymous variants in PCSK1 confer risk of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Evaluation of risk prediction updates from commercial genome-wide scans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-011-1023-8

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

21 January 2018

1 reference

12 December 2020

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

1 reference

12 December 2020

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

12 December 2020

Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups

1 reference

12 December 2020

Variants in MTNR1B influence fasting glucose levels

1 reference

12 December 2020

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

1 reference

12 December 2020

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

1 reference

12 December 2020

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

1 reference

12 December 2020

1 reference

12 December 2020

Common variants near MC4R are associated with fat mass, weight and risk of obesity

1 reference

12 December 2020

Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment

1 reference

12 December 2020

Variation across the allele frequency spectrum

1 reference

12 December 2020

Genetic testing for glucokinase mutations in clinically selected patients with MODY: a worthwhile investment.

1 reference

12 December 2020

Alpha-2 adrenergic activity of bromocriptine and quinpirole in chicken pineal gland. Effects on melatonin synthesis and [3H]rauwolscine binding

1 reference

12 December 2020

Type 2 diabetes: pathogenesis and treatment

1 reference

12 December 2020

Overexpression of Fto leads to increased food intake and results in obesity

1 reference

12 December 2020

Medicine. Life cycle of translational research for medical interventions

1 reference

12 December 2020

Genetic risk sum score comprised of common polygenic variation is associated with body mass index

1 reference

12 December 2020

Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program

1 reference

12 December 2020

10.1007/S00439-011-1023-8

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21647602