TDP-43 autoregulation: implications for disease (Q37890940)

24 August 2017

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title

TDP-43 autoregulation: implications for disease (English)

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24 August 2017

2

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24 August 2017

Mauricio Budini

1

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24 August 2017

publication date

18 June 2011

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Journal of Molecular Neuroscience

24 August 2017

published in

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24 August 2017

volume

45

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24 August 2017

issue

3

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24 August 2017

page(s)

473-479

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https://scigraph.springernature.com/pub.10.1007/s12031-011-9573-8

24 August 2017

exact match

0 references

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TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander

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Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

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Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis

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Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration

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TAR DNA-binding protein 43 in neurodegenerative disease

21 January 2018

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Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

21 January 2018

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TDP-43 is recruited to stress granules in conditions of oxidative insult.

21 January 2018

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TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

21 January 2018

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Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

21 January 2018

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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

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Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

21 January 2018

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Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

21 January 2018

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Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.

21 January 2018

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Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases

21 January 2018

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A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

21 January 2018

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Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

21 January 2018

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Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases

21 January 2018

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TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

21 January 2018

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TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization

21 January 2018

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Biomarkers in frontotemporal lobar degeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

21 January 2018

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Recent advances in our understanding of neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

21 January 2018

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Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics

21 January 2018

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Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

21 January 2018

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TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

A Drosophila model for TDP-43 proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

ALS and FTLD: two faces of TDP-43 proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Nonsense-mediated mRNA decay in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Molecular neuropathology of TDP-43 proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Review: Recent progress in frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

The exosome: a multipurpose RNA-decay machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Molecular pathways of frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Progressive motor weakness in transgenic mice expressing human TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Protein aggregation and defective RNA metabolism as mechanisms for motor neuron damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Research advances in amyotrophic lateral sclerosis, 2009 to 2010.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Implications of the prion-related Q/N domains in TDP-43 and FUS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

RNA processing pathways in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9573-8

Regulation of gene expression by TDP-43 and FUS/TLS in frontotemporal lobar degeneration

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21681666

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TDP-43 in aging and Alzheimer's disease - a review

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21681666

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pathogenic TARDBP mutations in amyotrophic lateral sclerosis and frontotemporal dementia: disease-associated pathways.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21681666

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12031-011-9573-8

1 reference

24 August 2017

1 reference