Recent advances in our understanding of neurodegeneration (Q34999535)

5 August 2017

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title

Recent advances in our understanding of neurodegeneration (English)

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5 August 2017

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Kurt A Jellinger

1

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5 August 2017

publication date

5 June 2009

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Journal of Neural Transmission

5 August 2017

published in

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5 August 2017

volume

116

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5 August 2017

issue

9

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5 August 2017

page(s)

1111-1162

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Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target

5 August 2017

cites work

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Is malfunction of the ubiquitin proteasome system the primary cause of alpha-synucleinopathies and other chronic human neurodegenerative disease?

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Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy

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Mitochondrial respiratory chain in brain homogenates: activities in different brain areas in patients with Alzheimer's disease.

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Axonal transport and neurodegenerative disease

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The role of caspase cleavage of tau in Alzheimer disease neuropathology

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Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

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The ubiquitin-proteasome pathway in Huntington's disease.

21 January 2018

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Environmental toxicity, oxidative stress and apoptosis: ménage à trois.

21 January 2018

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

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Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

21 January 2018

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Failure of protein quality control in amyotrophic lateral sclerosis

21 January 2018

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DNA repair deficiency and neurodegeneration

21 January 2018

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Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

21 January 2018

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Molecular basis of programmed cell death involved in neurodegeneration

21 January 2018

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Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

21 January 2018

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Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights

21 January 2018

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Mitochondrial DNA sequence variation and neurodegeneration

21 January 2018

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Fatty acid oxidation in the pathogenesis of Alzheimer's disease

21 January 2018

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Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

21 January 2018

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Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

21 January 2018

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Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

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Apoptotic and Oxidative Indicators in Alzheimer's Disease

21 January 2018

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Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis

21 January 2018

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Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

21 January 2018

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Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies

21 January 2018

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Neurotrophic factors in Alzheimer’s disease: role of axonal transport

21 January 2018

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Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0240-Y

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0240-Y

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0240-Y

Autophagy: principles and significance in health and disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00702-009-0240-Y

Autophagy in neurodegeneration and development

21 January 2018

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Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease.

21 January 2018

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21 January 2018

Apoptosis: an overview

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Metals and amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

12 December 2020

Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis

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12 December 2020

Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element

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12 December 2020

Neurotrophic support and oxidative stress: converging effects in the normal and diseased nervous system

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12 December 2020

Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases

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12 December 2020

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

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12 December 2020

A dynamic relationship between intracellular and extracellular pools of Abeta

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12 December 2020

Calcium signaling in neurodegeneration

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12 December 2020

Regulation and interplay of apoptotic and non-apoptotic cell death

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12 December 2020

Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway

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12 December 2020

Aggregate formation in Cu,Zn superoxide dismutase-related proteins

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12 December 2020

Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover

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12 December 2020

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

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12 December 2020

The endoplasmic reticulum and the unfolded protein response

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12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

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12 December 2020

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

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12 December 2020

Neurotrophins and neurodegeneration.

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12 December 2020

GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death

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12 December 2020

MicroRNAs (miRNAs) in neurodegenerative diseases

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12 December 2020

Protein misfolding and neurodegeneration

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12 December 2020

The PINK1/Parkin pathway regulates mitochondrial morphology

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12 December 2020

General aspects of neurodegeneration.

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12 December 2020

Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease

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12 December 2020

Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy

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12 December 2020

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

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12 December 2020

Dissecting the ER-associated degradation of a misfolded polytopic membrane protein

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12 December 2020

alpha-Synuclein and neuronal cell death

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12 December 2020

DNA repair, mitochondria, and neurodegeneration

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12 December 2020

Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies

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12 December 2020

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

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12 December 2020

Beta-synuclein occurs in vivo in lipid-associated oligomers and forms hetero-oligomers with alpha-synuclein

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12 December 2020

Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.

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12 December 2020

Autophagy in neurodegenerative disease: friend, foe or turncoat?

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12 December 2020

Biophysical characterization of intrinsically disordered proteins

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12 December 2020

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

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12 December 2020

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

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12 December 2020

Mitochondrial DNA damage and repair in neurodegenerative disorders

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12 December 2020

Neurodegenerative diseases and oxidative stress

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12 December 2020

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

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12 December 2020

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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12 December 2020

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

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12 December 2020

Ubiquitin and ubiquitin-like proteins as multifunctional signals

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12 December 2020

Mitochondria and neurodegeneration.

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12 December 2020

Interleukins, inflammation, and mechanisms of Alzheimer's disease

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12 December 2020

Neurons may live for decades with neurofibrillary tangles

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12 December 2020

Ionic liquids promote amyloid formation from alpha-synuclein

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12 December 2020

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death

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12 December 2020

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

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12 December 2020

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

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12 December 2020

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications

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12 December 2020

Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

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12 December 2020

Abeta aggregation and possible implications in Alzheimer's disease pathogenesis

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12 December 2020

Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease

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12 December 2020

The role of autophagy in age-related neurodegeneration

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12 December 2020

Chaperone signalling complexes in Alzheimer's disease.

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12 December 2020

Caspase-independent cell death

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12 December 2020

Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease.

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12 December 2020

Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease

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12 December 2020

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in

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12 December 2020

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

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12 December 2020

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

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12 December 2020

The role of alpha-synuclein in both neuroprotection and neurodegeneration

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12 December 2020

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

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12 December 2020

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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12 December 2020

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

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12 December 2020

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

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12 December 2020

The ubiquitin proteasome system in human disease

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12 December 2020

Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice

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12 December 2020

Mitochondrial dynamics and neurodegeneration

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12 December 2020

Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

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12 December 2020

Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation.

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12 December 2020

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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12 December 2020

LRRK2 and neurodegeneration

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

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12 December 2020

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

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12 December 2020

Oxidative damage in Huntington's disease pathogenesis

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12 December 2020

Mitochondrial dysfunction, oxidative stress and neurodegeneration.

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12 December 2020

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

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12 December 2020

Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes

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12 December 2020

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

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12 December 2020

Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments

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12 December 2020

Oxidative stress in neurodegeneration and available means of protection.

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12 December 2020

Autophagy and cell death.

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12 December 2020

Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress

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12 December 2020

Inflammation in Parkinson's disease: causative or epiphenomenal?

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12 December 2020

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

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12 December 2020

The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease

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12 December 2020

All-you-can-eat: autophagy in neurodegeneration and neuroprotection.

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12 December 2020

Following the leader: fibrillization of alpha-synuclein and tau.

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12 December 2020

Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies

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12 December 2020

Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application

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12 December 2020

Mitochondrial dysfunction and oxidative stress in Parkinson's disease.

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12 December 2020

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

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12 December 2020

Sequestration of iron by Lewy bodies in Parkinson's disease

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12 December 2020

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis

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12 December 2020

Multiple cascade effects of oxidative stress on astroglia

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12 December 2020

Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

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12 December 2020

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

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12 December 2020

Cell systems and the toxic mechanism(s) of alpha-synuclein

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12 December 2020

MAPT S305I mutation: implications for argyrophilic grain disease

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12 December 2020

Protein misfolding inside cells: the case of huntingtin and Huntington's disease

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12 December 2020

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

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12 December 2020

Formation of amyloid-beta oligomers in brain vascular smooth muscle cells transiently exposed to iron-induced oxidative stress

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12 December 2020

Polyglutamine neurodegeneration: protein misfolding revisited.

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12 December 2020

Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases.

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12 December 2020

Caspase-2: vestigial remnant or master regulator?

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12 December 2020

Abeta40 inhibits amyloid deposition in vivo.

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12 December 2020

A network dysfunction perspective on neurodegenerative diseases

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12 December 2020

CD4+ T cells mediate cytotoxicity in neurodegenerative diseases

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12 December 2020

Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction.

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12 December 2020

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

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12 December 2020

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

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12 December 2020

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

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12 December 2020

Oxidative stress induces macroautophagy of amyloid beta-protein and ensuing apoptosis.

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12 December 2020

Calcium ions in neuronal degeneration

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12 December 2020

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

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12 December 2020

Mitochondrial DNA mutations in disease, aging, and neurodegeneration

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12 December 2020

Spinocerebellar ataxias due to mitochondrial defects

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12 December 2020

Cell death by necrosis, a regulated way to go.

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12 December 2020

alpha-Synuclein: a potent inducer of tau pathology

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12 December 2020

Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease

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12 December 2020

[Recent progress and future direction of neurodegenerative disease research]

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12 December 2020

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

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12 December 2020

A role for alpha-synuclein in the regulation of dopamine biosynthesis

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12 December 2020

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

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12 December 2020

Dopamine complexes of iron in the etiology and pathogenesis of Parkinson's disease

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12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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12 December 2020

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

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12 December 2020

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

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12 December 2020

Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study.

1 reference

12 December 2020

The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up

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12 December 2020

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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12 December 2020

The effects of amyloid precursor protein on postsynaptic composition and activity.

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12 December 2020

A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

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12 December 2020

Selective neuronal degeneration in Huntington's disease

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12 December 2020

Evidence of oxidative stress in the neocortex in incidental Lewy body disease

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study

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12 December 2020

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

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12 December 2020

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

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12 December 2020

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

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12 December 2020

Huntingtin as an essential integrator of intracellular vesicular trafficking

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12 December 2020

Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers

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12 December 2020

Suppression of amyloid deposition leads to long-term reductions in Alzheimer's pathologies in Tg2576 mice

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12 December 2020

The role of neuroimmunomodulation in Alzheimer's disease.

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12 December 2020

Alterations of the microRNA network cause neurodegenerative disease.

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12 December 2020

Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden

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12 December 2020

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

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12 December 2020

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

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12 December 2020

Amyloid-beta aggregation

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12 December 2020

Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.

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12 December 2020

Increase in bax expression and apoptosis are associated in Huntington's disease progression

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12 December 2020

The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

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12 December 2020

The role of alpha-synuclein and tau in neurodegenerative movement disorders

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12 December 2020

Challenges in neuronal apoptosis

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12 December 2020

alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

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12 December 2020

Biochemical and pathological characterization of Lrrk2.

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12 December 2020

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

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12 December 2020

DJ-1 has a role in antioxidative stress to prevent cell death

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12 December 2020

Involvement of oxidative stress in Alzheimer disease

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12 December 2020

Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?

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12 December 2020

Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease

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12 December 2020

Cell death in the nervous system

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12 December 2020

DNA strand breaks, neurodegeneration and aging in the brain

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12 December 2020

Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy.

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12 December 2020

LRRK2 regulates synaptic vesicle endocytosis

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12 December 2020

Use of p62/SQSTM1 antibodies for neuropathological diagnosis

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12 December 2020

Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON)

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12 December 2020

Huntington's disease and mitochondrial DNA deletions: event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?!

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12 December 2020

Amyloid beta peptide, 4-hydroxynonenal and apoptosis

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12 December 2020

Inflammation and susceptibility to neurodegeneration: the use of unbiased genetics to decipher critical regulatory pathways

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12 December 2020

Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

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12 December 2020

The two-fold aspect of the interplay of amyloidogenic proteins with lipid membranes.

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12 December 2020

Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease.

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12 December 2020

Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?

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12 December 2020

Protein folding diseases and neurodegeneration: lessons learned from yeast

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12 December 2020

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

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12 December 2020

Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps

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12 December 2020

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

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12 December 2020

Immunization in Alzheimer's disease: naïve hope or realistic clinical potential?

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12 December 2020

Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases

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12 December 2020

Nanoimaging for protein misfolding and related diseases

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12 December 2020

To die or not to die: that is the autophagic question

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12 December 2020

Brain proteasomal function in sporadic Parkinson's disease and related disorders

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12 December 2020

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

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12 December 2020

Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease

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12 December 2020

Expansion and evolution of cell death programmes

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12 December 2020

Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease

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12 December 2020

Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases

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12 December 2020

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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12 December 2020

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

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12 December 2020

The roles of intracellular protein-degradation pathways in neurodegeneration

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12 December 2020

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

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12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

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12 December 2020

The ubiquitin-proteasome system in Alzheimer's disease

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12 December 2020

Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death

1 reference

12 December 2020

The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy

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12 December 2020

Caspase-1 activation of caspase-6 in human apoptotic neurons

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12 December 2020

Protein misfolding disorders: pathogenesis and intervention

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12 December 2020

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

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12 December 2020

Glycolitic enzymes are targets of oxidation in aged human frontal cortex and oxidative damage of these proteins is increased in progressive supranuclear palsy

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12 December 2020

Glutathionylation of the pro-apoptotic protein p53 in Alzheimer's disease brain: implications for AD pathogenesis

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12 December 2020

Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death

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12 December 2020

Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease

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12 December 2020

Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease

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12 December 2020

Autophagy in cell death: an innocent convict?

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12 December 2020

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

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12 December 2020

Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.

1 reference

12 December 2020

Regulation of the apoptosis-necrosis switch

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12 December 2020

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

1 reference

12 December 2020

The neuronal ubiquitin-proteasome system: murine models and their neurological phenotype.

1 reference

12 December 2020

Structural characterization of a soluble amyloid beta-peptide oligomer.

1 reference

12 December 2020

Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease

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12 December 2020

Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses

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12 December 2020

Is the ubiquitin-proteasome system impaired in Huntington's disease?

1 reference

12 December 2020

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

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12 December 2020

Proteomic identification of novel proteins in cortical lewy bodies

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12 December 2020

Regulation of p53 family members by the ubiquitin-like SUMO system

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12 December 2020

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

1 reference

12 December 2020

Cell death by necrosis: towards a molecular definition

1 reference

12 December 2020

Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies

1 reference

12 December 2020

Oxidative stress in neurodegeneration: cause or consequence?

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12 December 2020

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

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12 December 2020

Ubiquitin-binding domains and their role in the DNA damage response

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12 December 2020

Molecular pathophysiology of Parkinson's disease

1 reference

12 December 2020

Biological and chemical approaches to diseases of proteostasis deficiency

1 reference

12 December 2020

Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

1 reference

12 December 2020

Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models

1 reference

12 December 2020

Role of brain-derived neurotrophic factor in Huntington's disease

1 reference

12 December 2020

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

1 reference

12 December 2020

Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.

1 reference

12 December 2020

DCTN1 mutations in Perry syndrome

1 reference

12 December 2020

Programmed cell death mechanisms in neurological disease

1 reference

12 December 2020

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

1 reference

12 December 2020

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

1 reference

12 December 2020

A possible role for humoral immunity in the pathogenesis of Parkinson's disease

1 reference

12 December 2020

RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation?

1 reference

12 December 2020

The effects of TNF deficiency on age-related cognitive performance.

1 reference

12 December 2020

Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease

1 reference

12 December 2020

Excitotoxic neuronal death and the pathogenesis of Huntington's disease

1 reference

12 December 2020

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

1 reference

12 December 2020

Damage control: DNA repair, transcription, and the ubiquitin-proteasome system

1 reference

12 December 2020

Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease.

1 reference

12 December 2020

Spontaneous aggregation and altered intracellular distribution of endogenous alpha-synuclein during neuronal apoptosis.

1 reference

12 December 2020

Polyglutamine diseases and molecular chaperones

1 reference

12 December 2020

Chaperones increase association of tau protein with microtubules

1 reference

12 December 2020

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death

1 reference

12 December 2020

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

12 December 2020

The ubiquitylation machinery of the endoplasmic reticulum

1 reference

12 December 2020

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

1 reference

12 December 2020

Neurotrophins, synaptic plasticity and dementia

1 reference

12 December 2020

Alzheimer disease pathology as a host response

1 reference

12 December 2020

Clearance of mutant aggregate-prone proteins by autophagy.

1 reference

12 December 2020

Friedreich ataxia: the oxidative stress paradox

1 reference

12 December 2020

Signal transduction cascades associated with oxidative stress in Alzheimer's disease

1 reference

12 December 2020

Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors

1 reference

12 December 2020

Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders

1 reference

12 December 2020

Mechanisms of neurodegeneration in Huntington's disease.

1 reference

12 December 2020

Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease

1 reference

12 December 2020

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

1 reference

12 December 2020

The relevance of iron in the pathogenesis of Parkinson's disease.

1 reference

12 December 2020

Tau aggregates and tau pathology.

1 reference

12 December 2020

Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases

1 reference

12 December 2020

Microglial activation induced by neurodegeneration: a proteomic analysis

1 reference

12 December 2020

Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies

1 reference

12 December 2020

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1 reference

12 December 2020

Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo.

1 reference

12 December 2020

Tau pathophysiology in neurodegeneration: a tangled issue

1 reference

12 December 2020

Cell death: protein misfolding and neurodegenerative diseases

1 reference

12 December 2020

Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies

1 reference

12 December 2020

Axonal transport defects: a common theme in neurodegenerative diseases

1 reference

12 December 2020

Proteasome regulators: activators and inhibitors.

1 reference

12 December 2020

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

12 December 2020

Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

1 reference

12 December 2020

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

1 reference

12 December 2020

1 reference

12 December 2020

Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

1 reference

12 December 2020

Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement.

1 reference

12 December 2020

Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: the role of innate immunity

1 reference

12 December 2020

Mechanisms of neuronal death in disease: defining the models and the players.

1 reference

12 December 2020

Mechanisms of prion protein aggregation

1 reference

12 December 2020

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

The nuclear proteasome and the degradation of oxidatively damaged proteins.

1 reference

12 December 2020

Molecular and cellular aspects of protein misfolding and disease

1 reference

12 December 2020

Autophagy-physiology and pathophysiology

1 reference

12 December 2020

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

1 reference

12 December 2020

Calcium and neurodegeneration

1 reference

12 December 2020

In vitro and in vivo neurotoxicity of prion protein oligomers.

1 reference

12 December 2020

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease.

1 reference

12 December 2020

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

1 reference

12 December 2020

Molecular mechanisms and pathophysiology of necrotic cell death

1 reference

12 December 2020

Amyloid fibril formation can proceed from different conformations of a partially unfolded protein

1 reference

12 December 2020

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

1 reference

12 December 2020

Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system.

1 reference

12 December 2020

The axonal transport of mitochondria.

1 reference

12 December 2020

Chromogranin peptides in amyotrophic lateral sclerosis.

1 reference

12 December 2020

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

1 reference

12 December 2020

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

1 reference

12 December 2020

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy.

1 reference

12 December 2020

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.

1 reference

12 December 2020

Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.

1 reference

12 December 2020

Alpha-synuclein misfolding and neurodegenerative diseases

1 reference

12 December 2020

Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space

1 reference

12 December 2020

Autophagic neuron death

1 reference

12 December 2020

Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease

1 reference

12 December 2020

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches

1 reference

12 December 2020

Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease

1 reference

12 December 2020

The significance of neuroinflammation in understanding Alzheimer's disease.

1 reference

12 December 2020

Aggresome formation and neurodegenerative diseases: therapeutic implications

1 reference

12 December 2020

Proteasome-independent functions of ubiquitin in endocytosis and signaling

1 reference

12 December 2020

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

1 reference

12 December 2020

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death.

1 reference

12 December 2020

Golgi apparatus and neurodegenerative diseases

1 reference

12 December 2020

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

1 reference

12 December 2020

Expression and activity of antioxidants in the brain in progressive supranuclear palsy

1 reference

12 December 2020

Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease

1 reference

12 December 2020

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

1 reference

12 December 2020

Protein degradation in Parkinson disease revisited: it's complex

1 reference

12 December 2020

Mitochondrial membrane permeabilization: the sine qua non for cell death

1 reference

12 December 2020

Axonal transport of human α-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations

1 reference

12 December 2020

Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies

1 reference

12 December 2020

Inclusion bodies: Specificity in their aggregation process and amyloid-like structure

1 reference

12 December 2020

What causes cell death in Parkinson's disease?

1 reference

12 December 2020

Apoptosis in Parkinson's disease: signals for neuronal degradation

1 reference

12 December 2020

MicroRNAs in neurodegeneration

1 reference

12 December 2020

Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease

1 reference

12 December 2020

The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.

1 reference

12 December 2020

Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain

1 reference

12 December 2020

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

1 reference

12 December 2020

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

1 reference

12 December 2020

Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein

1 reference

12 December 2020

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

1 reference

12 December 2020

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

1 reference

12 December 2020

Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence

1 reference

12 December 2020

The role of tau phosphorylation and cleavage in neuronal cell death

1 reference

12 December 2020

Protein aggregation in Alzheimer's disease and other neoropathological disorders

1 reference

12 December 2020

Autophagy: a lysosomal degradation pathway with a central role in health and disease

1 reference

12 December 2020

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

1 reference

12 December 2020

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

1 reference

12 December 2020

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

12 December 2020

Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration

1 reference

12 December 2020

Neuronal inclusions in degenerative disorders Do they represent static features or a key to understand the dynamics of the disease?

1 reference

12 December 2020

Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease

1 reference

12 December 2020

Modulation of neurodegeneration by molecular chaperones

1 reference

12 December 2020

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

1 reference

12 December 2020

The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP).

1 reference

12 December 2020

Mitochondrial damage modulates alternative splicing in neuronal cells: implications for neurodegeneration

1 reference

12 December 2020

ALS and FTLD: two faces of TDP-43 proteinopathy

1 reference

12 December 2020

Heat shock protein 27 in neuronal survival and neurite outgrowth

1 reference

12 December 2020

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

1 reference

12 December 2020

Mitochondria in Parkinson disease: back in fashion with a little help from genetics

1 reference

12 December 2020

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

1 reference

12 December 2020

K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons

1 reference

12 December 2020

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

1 reference

12 December 2020

The p38 MAP kinase signaling pathway in Alzheimer's disease.

1 reference

12 December 2020

Regulation of DNA repair by parkin.

1 reference

12 December 2020

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

1 reference

12 December 2020

Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease

1 reference

12 December 2020

Effects of ubiquilin 1 on the unfolded protein response

1 reference

12 December 2020

TrkA pathway activation induced by amyloid-beta (Abeta).

1 reference

12 December 2020

Role of complement in neurodegeneration and neuroinflammation.

1 reference

12 December 2020

Amyloid-beta immunisation for Alzheimer's disease

1 reference

12 December 2020

Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity

1 reference

12 December 2020

Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease

1 reference

12 December 2020

The role of mitochondria in inherited neurodegenerative diseases

1 reference

12 December 2020

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

1 reference

12 December 2020

Protein folding and misfolding on surfaces.

1 reference

12 December 2020

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

1 reference

12 December 2020

Why have we failed to achieve neuroprotection in Parkinson's disease?

1 reference

12 December 2020

Superoxide dismutase and the death of motoneurons in ALS.

1 reference

12 December 2020

Autophagic cell death: the story of a misnomer

1 reference

12 December 2020

Oxidative and inflammatory pathways in Parkinson's disease

1 reference

12 December 2020

Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice

1 reference

12 December 2020

Lysozyme Amyloid Oligomers and Fibrils Induce Cellular Death via Different Apoptotic/Necrotic Pathways

1 reference

12 December 2020

Delineation of Early Changes in Cases with Progressive Supranuclear Palsy-Like Pathology. Astrocytes in Striatum are Primary Targets of Tau Phosphorylation and GFAP Oxidation

1 reference

12 December 2020

Mitochondria, calcium and cell death: a deadly triad in neurodegeneration

1 reference

12 December 2020

Oxidative RNA damage and neurodegeneration

1 reference

12 December 2020

Mechanisms underlying ubiquitination

1 reference

12 December 2020

Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions

1 reference

12 December 2020

Mitochondrial alterations in Parkinson's disease: new clues

1 reference

12 December 2020

Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain

1 reference

12 December 2020

DNA damage and repair: relevance to mechanisms of neurodegeneration

1 reference

12 December 2020

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

1 reference

12 December 2020

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.

1 reference

12 December 2020

Alpha-synuclein: normal function and role in neurodegenerative diseases.

1 reference

12 December 2020

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

12 December 2020

Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases

1 reference

12 December 2020

Ubiquitin-independent degradation of proteins by the proteasome

1 reference

12 December 2020

Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.

1 reference

12 December 2020

Role of axonal transport in neurodegenerative diseases

1 reference

12 December 2020

Clinical correlates of mitochondrial function in Huntington's disease muscle

1 reference

12 December 2020

Phagocytosis of apoptotic cells: a matter of balance

1 reference

12 December 2020

Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

1 reference

12 December 2020

Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration

1 reference

12 December 2020

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

12 December 2020

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

1 reference

12 December 2020

Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress

1 reference

12 December 2020

Targeting programmed cell death in neurodegenerative diseases

1 reference

12 December 2020

Autophagosome and phagosome

1 reference

12 December 2020

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

1 reference

12 December 2020

Neurodegenerative diseases target large-scale human brain networks

1 reference

12 December 2020

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

1 reference

12 December 2020

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

1 reference

12 December 2020

Lipoperoxidation is selectively involved in progressive supranuclear palsy

1 reference

12 December 2020

Oxidative stress and neurodegeneration: where are we now?

1 reference

12 December 2020

Microglial activation and dopamine terminal loss in early Parkinson's disease

1 reference

12 December 2020

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

1 reference

12 December 2020

Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging

1 reference

12 December 2020

Cerebral mitochondrial metabolism in early Parkinson's disease

1 reference

12 December 2020

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.

1 reference

12 December 2020

Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease.

1 reference

12 December 2020

On the key role played by altered protein conformation in Parkinson's disease

1 reference

12 December 2020

Mitochondrial fragmentation in neurodegeneration

1 reference

12 December 2020

[Mitochondrial encephalomyopathies]

1 reference

12 December 2020

The ubiquitin-proteasome pathway in cell cycle control.

1 reference

12 December 2020

Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies

1 reference

12 December 2020

Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3.

1 reference

12 December 2020

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

1 reference

12 December 2020

Apoptosis: a review of programmed cell death

1 reference

12 December 2020

Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration

1 reference

12 December 2020

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

12 December 2020

Protein aggregation, metals and oxidative stress in neurodegenerative diseases

1 reference

12 December 2020

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

1 reference

12 December 2020

Towards an understanding of kinesin-1 dependent transport pathways through the study of protein-protein interactions

1 reference

12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

12 December 2020

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins

1 reference

12 December 2020

Neurodegenerative diseases and oxidative stress

1 reference

12 December 2020

Involvement of Maillard reactions in Alzheimer disease

1 reference

12 December 2020

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

1 reference

12 December 2020

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

1 reference

12 December 2020

Apoptosis-inducing factor: a matter of neuron life and death

1 reference

12 December 2020

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

1 reference

12 December 2020

Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death

1 reference

12 December 2020

Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism

1 reference

12 December 2020

Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.

1 reference

12 December 2020

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

1 reference

12 December 2020

No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease

1 reference

12 December 2020

Prion protein misfolding and disease

1 reference

12 December 2020

TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis

1 reference

12 December 2020

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

12 December 2020

Autophagy in neuroprotection and neurodegeneration: A question of balance.

1 reference

12 December 2020

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases

1 reference

12 December 2020

Mitochondria: more than just a powerhouse

1 reference

12 December 2020

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

1 reference

12 December 2020

Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.

1 reference

12 December 2020

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

1 reference

12 December 2020

Debris clearance by microglia: an essential link between degeneration and regeneration.

1 reference

12 December 2020

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

1 reference

12 December 2020

The role of protein aggregates in neuronal pathology: guilty, innocent, or just trying to help?

1 reference

12 December 2020

The aggregation and fibrillation of alpha-synuclein

1 reference

12 December 2020

Ubiquitin dimers control the hydrolase activity of UCH-L3

1 reference

12 December 2020

Global changes to the ubiquitin system in Huntington's disease.

1 reference

12 December 2020

DNA damage and repair in Alzheimer's disease

1 reference

12 December 2020

[Parkin and mitochondria]

1 reference

12 December 2020

Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models

1 reference

12 December 2020

Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

1 reference

12 December 2020

Abeta inhibits the proteasome and enhances amyloid and tau accumulation

1 reference

12 December 2020

Detecting morphologically distinct oligomeric forms of alpha-synuclein

1 reference

12 December 2020

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

1 reference

12 December 2020

Microglia and Alzheimer's disease pathogenesis

1 reference

12 December 2020

Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2.

1 reference

12 December 2020

Autophagy in the Pathogenesis of Disease

1 reference

12 December 2020

The role of the immune system in clearance of Abeta from the brain

1 reference

12 December 2020

SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization

1 reference

12 December 2020

Imaging microglial activation in Huntington's disease

1 reference

12 December 2020

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

1 reference

12 December 2020

Mitochondria and neurodegeneration

1 reference

12 December 2020

Alzheimer's disease and NGF signaling

1 reference

12 December 2020

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

1 reference

12 December 2020

Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction

1 reference

12 December 2020

Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase?

1 reference

12 December 2020

No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases

1 reference

12 December 2020

Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation

1 reference

12 December 2020

Protective autoimmunity in the nervous system

1 reference

12 December 2020

Microglial activation in presymptomatic Huntington's disease gene carriers

1 reference

12 December 2020

Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

1 reference

12 December 2020

Ubiquitin-proteasome system as a modulator of cell fate

1 reference

12 December 2020

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

1 reference

12 December 2020

Aggresome formation by mutant prion proteins: the unfolding role of proteasomes in familial prion disorders

1 reference

12 December 2020

Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases

1 reference

12 December 2020

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

12 December 2020

ER stress and neurodegenerative diseases

1 reference

12 December 2020

MPTP as a mitochondrial neurotoxic model of Parkinson's disease

1 reference

12 December 2020

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

1 reference

12 December 2020

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

1 reference

12 December 2020

Neuronal apoptosis in neurodegeneration

1 reference

12 December 2020

Protein-misfolding diseases and chaperone-based therapeutic approaches

1 reference

12 December 2020

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

1 reference

12 December 2020

Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease

1 reference

12 December 2020

Ubiquitin-proteasome system and Parkinson's disease

1 reference

12 December 2020

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

1 reference

12 December 2020

Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy

1 reference

12 December 2020

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

12 December 2020

Oxidative stress and neurotoxicity

1 reference

12 December 2020

Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

1 reference

12 December 2020

Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants

1 reference

12 December 2020

Axonal transport of synucleins is mediated by all rate components

1 reference

12 December 2020

Characterization of apoptotic pathway associated with caspase-independent excision of DNA loop domains.

1 reference

12 December 2020

Ubiquitin binding proteins protect ubiquitin conjugates from disassembly

1 reference

12 December 2020

Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

1 reference

12 December 2020

OPA1-associated disorders: phenotypes and pathophysiology.

1 reference

12 December 2020

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

1 reference

12 December 2020

The cytoskeleton in neurodegenerative diseases

1 reference

12 December 2020

TDP-43: a novel neurodegenerative proteinopathy

1 reference

12 December 2020

The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

1 reference

12 December 2020

MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein.

1 reference

12 December 2020

Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models

1 reference

12 December 2020

Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?

1 reference

12 December 2020

Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

12 December 2020

PP1 inhibition by Abeta peptide as a potential pathological mechanism in Alzheimer's disease

1 reference

12 December 2020

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

1 reference

12 December 2020

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

1 reference

12 December 2020

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

12 December 2020

Effects of overexpression of huntingtin proteins on mitochondrial integrity

1 reference

12 December 2020

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component

1 reference

12 December 2020

The rotenone model of parkinsonism--the five years inspection.

1 reference

12 December 2020

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

1 reference

12 December 2020

Molecular chaperones: multiple functions, pathologies, and potential applications

1 reference

12 December 2020

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

12 December 2020

Mitochondrial alterations in Alzheimer's disease

1 reference

12 December 2020

Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

1 reference

12 December 2020

A role for ubiquitin in the clearance of nonfunctional rRNAs

1 reference

12 December 2020

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

12 December 2020

Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity

1 reference

12 December 2020

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

1 reference

12 December 2020

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

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12 December 2020

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

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12 December 2020

Interaction of ?-synuclein and tau genotypes in Parkinson's disease

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12 December 2020

Iron, brain ageing and neurodegenerative disorders

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12 December 2020

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

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12 December 2020

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

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12 December 2020

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

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12 December 2020

Mitochondria, mitochondrial DNA and Alzheimer's disease. What comes first?

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12 December 2020

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

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12 December 2020

Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications.

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12 December 2020

TDP-43 pathology in familial British dementia

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12 December 2020

Update on the pathogenesis of Parkinson's disease

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12 December 2020

10.1007/S00702-009-0240-Y

Identifiers

DOI

1 reference

5 August 2017

1 reference