Progress and challenges in the discovery of macrofilaricidal drugs (Q37912232)

25 August 2017

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title

Progress and challenges in the discovery of macrofilaricidal drugs (English)

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25 August 2017

Timothy G Geary

1

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PubMed ID

21819332

25 August 2017

Charles D Mackenzie

series ordinal

2

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25 August 2017

1 August 2011

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Expert Review of Anti-infective Therapy

25 August 2017

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25 August 2017

9

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25 August 2017

681-695

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25 August 2017

8

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The global programme to eliminate lymphatic filariasis: health impact after 8 years

25 August 2017

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Control of onchocerciasis

21 January 2018

1 reference

The Mectizan Donation Program (MDP).

21 January 2018

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Heartworm disease in animals and humans

21 January 2018

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Heartworm biology, treatment, and control

21 January 2018

1 reference

Ivermectin 20 years on: maturation of a wonder drug

21 January 2018

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Avermectin binding in Caenorhabditis elegans. A two-state model for the avermectin binding site.

21 January 2018

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High-affinity ivermectin binding to recombinant subunits of the Haemonchus contortus glutamate-gated chloride channel

21 January 2018

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Final report of the Conference on the eradicability of Onchocerciasis

21 January 2018

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Elimination of lymphatic filariasis: do we have the drugs to complete the job?

21 January 2018

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Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug

21 January 2018

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Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients

21 January 2018

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Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi

21 January 2018

1 reference

Unresolved issues in anthelmintic pharmacology for helminthiases of humans

21 January 2018

1 reference

Treatment of bancroftian filariasis in Recife, Brazil: a two-year comparative study of the efficacy of single treatments with ivermectin or diethylcarbamazine.

21 January 2018

1 reference

Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology.

21 January 2018

1 reference

Clinical picture, epidemiology and outcome of Loa-associated serious adverse events related to mass ivermectin treatment of onchocerciasis in Cameroon

21 January 2018

1 reference

Loa loa encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: implications for the future

21 January 2018

1 reference

Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study

21 January 2018

1 reference

Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

21 January 2018

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P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus

21 January 2018

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Evaluation of efficacy of heartworm preventive products at the FDA.

21 January 2018

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Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype

21 January 2018

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Clinical picture and outcome of Serious Adverse Events in the treatment of Onchocerciasis

21 January 2018

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Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis

21 January 2018

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Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

21 January 2018

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Combined ivermectin and doxycycline treatment has microfilaricidal and adulticidal activity against Dirofilaria immitis in experimentally infected dogs

21 January 2018

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A combination of doxycycline and ivermectin is adulticidal in dogs with naturally acquired heartworm disease (Dirofilaria immitis).

21 January 2018

1 reference

Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon

21 January 2018

1 reference

The safety-net story about macrocyclic lactone heartworm preventives: a review, an update, and recommendations

21 January 2018

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Treatment strategies underpinning the global programme to eliminate lymphatic filariasis

21 January 2018

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Lymphatic filariasis and onchocerciasis

21 January 2018

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Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment

21 January 2018

1 reference

Heartworm and Wolbachia: therapeutic implications

21 January 2018

1 reference

The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans

21 January 2018

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Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship

21 January 2018

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Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway

21 January 2018

1 reference

Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals.

21 January 2018

1 reference

21 January 2018

1 reference

Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action

21 January 2018

1 reference

Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle

21 January 2018

1 reference

Influence of the cyclooctadepsipeptides PF1022A and PF1022E as natural products on the design of semi-synthetic anthelmintics such as emodepside.

21 January 2018

1 reference

Albendazole: a broad spectrum anthelminthic for treatment of individuals and populations

21 January 2018

1 reference

Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.

21 January 2018

1 reference

Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice.

21 January 2018

1 reference

Induction of chromosomal aberrations, cytotoxicity, and morphological transformation in mammalian cells by the antiparasitic drug flubendazole and the antineoplastic drug harringtonine

21 January 2018

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Effect of oral dosing vehicles on the developmental toxicity of flubendazole in rats

21 January 2018

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The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

21 January 2018

1 reference

UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle.

21 January 2018

1 reference

Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep

21 January 2018

1 reference

Nitazoxanide: a review of its use in the treatment of gastrointestinal infections

21 January 2018

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Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells

21 January 2018

1 reference

Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes

21 January 2018

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A new class of anthelmintics effective against drug-resistant nematodes

21 January 2018

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A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep

21 January 2018

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Phylogenomics of ligand-gated ion channels predicts monepantel effect

21 January 2018

1 reference

Marcfortine and paraherquamide class of anthelmintics: discovery of PNU-141962.

21 January 2018

1 reference

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand

21 January 2018

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Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China

21 January 2018

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The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist

21 January 2018

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The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats

21 January 2018

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Recent developments in search of antifilarial agents

21 January 2018

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Towards novel antifilarial drugs: challenges and recent developments

21 January 2018

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The challenges of developing novel antiparasitic drugs

21 January 2018

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Challenges in drug discovery for novel antifilarials

21 January 2018

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Prospects for rational approaches to anthelmintic discovery

21 January 2018

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Mechanism-based screening: discovery of the next generation of anthelmintics depends upon more basic research

21 January 2018

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Caenorhabditis elegans: how good a model for veterinary parasites?

21 January 2018

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A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

21 January 2018

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Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans

21 January 2018

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Anthelmintic discovery and development in the animal health industry

21 January 2018

1 reference

Genomic filtering: an approach to discovering novel antiparasitics

21 January 2018

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Mining predicted essential genes of Brugia malayi for nematode drug targets

21 January 2018

1 reference

Genomic-scale prioritization of drug targets: the TDR Targets database

21 January 2018

1 reference

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

21 January 2018

1 reference

RNAi-based discovery and validation of new drug targets in filarial nematodes

21 January 2018

1 reference

RNA interference in parasitic nematodes of animals: a reality check?

21 January 2018

1 reference

Onchocerca volvulus: parasitologic and serologic responses in experimentally infected chimpanzees and mangabey monkeys

21 January 2018

1 reference

Presbytis entellus: a primate model for parasitic disease research.

21 January 2018

1 reference

Of mice, cattle, and humans: the immunology and treatment of river blindness

21 January 2018

1 reference

The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.

21 January 2018

1 reference

Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products

21 January 2018

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Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling

21 January 2018

1 reference

Innovative lead discovery strategies for tropical diseases

21 January 2018

1 reference

The Concept Paper on the Helminth Drug Initiative. Onchocerciasis/lymphatic filariasis and schistosomiasis: opportunities and challenges for the discovery of new drugs/diagnostics

21 January 2018

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Advancing drug innovation for neglected diseases-criteria for lead progression

21 January 2018

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COMPARISON OF FLUBENDAZOLE AND DIETHYLCARBAMAZINE IN TREATMENT OF ONCHOCERCIASIS

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERI.11.76

1 reference

25 August 2017

1 reference

PubMed ID

21819332