Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look? (Q37921797)

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scientific article published on 25 August 2011

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English	Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look?	scientific article published on 25 August 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 August 2017

1 reference

Europe PubMed Central

Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look? (English)

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Europe PubMed Central

PubMed publication ID

25 August 2017

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David Bruce

1

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Europe PubMed Central

PubMed publication ID

25 August 2017

Peng H Tan

2

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Europe PubMed Central

PubMed publication ID

25 August 2017

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publication date

25 August 2011

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Europe PubMed Central

PubMed publication ID

25 August 2017

Expert Opinion on Investigational Drugs

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Europe PubMed Central

PubMed publication ID

25 August 2017

20

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Europe PubMed Central

PubMed publication ID

25 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

1413-1434

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Europe PubMed Central

PubMed publication ID

25 August 2017

VEGF receptor signalling - in control of vascular function

1 reference

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Review: monoclonal antibodies to the vascular endothelial growth factor receptor-2 in cancer therapy

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An overview of small-molecule inhibitors of VEGFR signaling

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Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation

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The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells

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Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1).

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FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?

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The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis

1 reference

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21 January 2018

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

1 reference

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The role of the VEGF-C/VEGFR-3 axis in cancer progression

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Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

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Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3.

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What Is the Evidence That Tumors Are Angiogenesis Dependent?

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Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

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The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review

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Mechanisms of resistance to antiangiogenesis therapy

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Tyrphostins and other tyrosine kinase inhibitors

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Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis

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Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.

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A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability

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Targeting cancer with small molecule kinase inhibitors

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Mechanisms of drug inhibition of signalling molecules

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Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo

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Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer

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Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies

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Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma

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Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study

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AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts

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AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer

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Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib

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Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer

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AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

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Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

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Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane

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Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer

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21 January 2018

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Identifiers

10.1517/13543784.2011.611801

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

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