Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria (Q37929759)

25 August 2017

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title

Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria (English)

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25 August 2017

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Plasmodium falciparum

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2

Kevin C Kain

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25 August 2017

Sarah J Higgins

1

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PubMed ID

21905788

25 August 2017

W Conrad Liles

series ordinal

3

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25 August 2017

1 September 2011

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Expert Review of Anti-infective Therapy

25 August 2017

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25 August 2017

9

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25 August 2017

9

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25 August 2017

803-819

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Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

25 August 2017

1 reference

Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial

21 January 2018

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Cerebral malaria in children is associated with long-term cognitive impairment

21 January 2018

1 reference

Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome

21 January 2018

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Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children

21 January 2018

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Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya

21 January 2018

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Damage control in host-pathogen interactions

21 January 2018

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Immunity to malaria: more questions than answers

21 January 2018

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Acquired immunity to malaria

21 January 2018

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TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria.

21 January 2018

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The immune response to Plasmodium falciparum malaria.

21 January 2018

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Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy con

21 January 2018

1 reference

The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria

21 January 2018

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High-level cerebellar expression of cytokines and adhesion molecules in fatal, paediatric, cerebral malaria

21 January 2018

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Clinical significance of sequestration in adults with severe malaria

21 January 2018

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Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria

21 January 2018

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Differentiating the pathologies of cerebral malaria by postmortem parasite counts

21 January 2018

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Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes

21 January 2018

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Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome

21 January 2018

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The neuropathology of fatal cerebral malaria in malawian children

21 January 2018

1 reference

Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies

21 January 2018

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High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children

21 January 2018

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Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

21 January 2018

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Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition

21 January 2018

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Functional architecture of Weibel-Palade bodies

21 January 2018

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Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

21 January 2018

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Blood coagulation, inflammation, and malaria

21 January 2018

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Dysregulation of coagulation in cerebral malaria.

21 January 2018

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Immunological processes in malaria pathogenesis.

21 January 2018

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Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins

21 January 2018

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Perfusion abnormalities in children with cerebral malaria and malarial retinopathy

21 January 2018

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Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria

21 January 2018

1 reference

Magnetic resonance imaging research in sub-Saharan Africa: challenges and satellite-based networking implementation

21 January 2018

1 reference

The murine cerebral malaria phenomenon

21 January 2018

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Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

21 January 2018

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Neuropathogenesis of human and murine malaria.

21 January 2018

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Cerebral malaria: human versus mouse studies.

21 January 2018

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Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria

21 January 2018

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Diagnosis and management of the neurological complications of falciparum malaria

21 January 2018

1 reference

Mortality after fluid bolus in African children with severe infection

21 January 2018

1 reference

Fluid resuscitation in acute illness--time to reappraise the basics

21 January 2018

1 reference

The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene

21 January 2018

1 reference

Molecular mechanisms of glucocorticoid action and resistance

21 January 2018

1 reference

Use of dexamethasone in cerebral malaria.

21 January 2018

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High-dose dexamethasone in quinine-treated patients with cerebral malaria: a double-blind, placebo-controlled trial

21 January 2018

1 reference

Dexamethasone proves deleterious in cerebral malaria. A double-blind trial in 100 comatose patients.

21 January 2018

1 reference

Intravenous immunoglobulin in the treatment of paediatric cerebral malaria

21 January 2018

1 reference

Curdlan sulphate in human severe/cerebral Plasmodium falciparum malaria

21 January 2018

1 reference

Cytokine expression in the brain in human cerebral malaria

21 January 2018

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Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria

21 January 2018

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Inhibition of endogenous TNF formation by pentoxifylline

21 January 2018

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Pentoxifylline adjunct improves prognosis of human cerebral malaria in adults

21 January 2018

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Pentoxifylline as an adjunct therapy in children with cerebral malaria

21 January 2018

1 reference

Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate

21 January 2018

1 reference

Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria

21 January 2018

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Risk factors for severe disease in adults with falciparum malaria

21 January 2018

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Indicators of life-threatening malaria in African children

21 January 2018

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A simple score to predict the outcome of severe malaria in adults

21 January 2018

1 reference

The Lambaréné Organ Dysfunction Score (LODS) is a simple clinical predictor of fatal malaria in African children

21 January 2018

1 reference

Retinal pathology of pediatric cerebral malaria in Malawi

21 January 2018

1 reference

Biomarkers and surrogate end points--the challenge of statistical validation

21 January 2018

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Biomarkers for pediatric sepsis and septic shock

21 January 2018

1 reference

Nano/Microfluidics for diagnosis of infectious diseases in developing countries

21 January 2018

1 reference

Tumor necrosis factor and disease severity in children with falciparum malaria.

21 January 2018

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Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria

21 January 2018

1 reference

Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha

21 January 2018

1 reference

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

21 January 2018

1 reference

Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study

21 January 2018

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Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study

21 January 2018

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Intravascular immunity: the host-pathogen encounter in blood vessels.

21 January 2018

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Evolving functions of endothelial cells in inflammation

21 January 2018

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The L-arginine-nitric oxide pathway

21 January 2018

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Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines

21 January 2018

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Anti-Adhesive Effect of Nitric Oxide on Plasmodium falciparum Cytoadherence under Flow

21 January 2018

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Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.

21 January 2018

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Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

21 January 2018

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Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production

21 January 2018

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Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria

21 January 2018

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Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome

21 January 2018

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Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria

21 January 2018

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Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.

21 January 2018

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Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology

21 January 2018

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Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations

21 January 2018

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Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics

21 January 2018

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

21 January 2018

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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

21 January 2018

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

21 January 2018

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Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression

21 January 2018

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Recognition of plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system

21 January 2018

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The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

21 January 2018

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

21 January 2018

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Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria

21 January 2018

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Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children

21 January 2018

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COMP-angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

21 January 2018

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Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1

21 January 2018

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Angiopoietin-1 protects the adult vasculature against plasma leakage.

21 January 2018

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Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

21 January 2018

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Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

21 January 2018

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VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.

21 January 2018

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Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis

21 January 2018

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VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.

21 January 2018

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Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells

21 January 2018

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High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria.

21 January 2018

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VEGF promotes malaria-associated acute lung injury in mice

21 January 2018

1 reference

Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India

21 January 2018

1 reference

Peroxisome proliferator activating receptor (PPAR) in cerebral malaria (CM): a novel target for an additional therapy

21 January 2018

1 reference

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

The mechanisms of action of PPARs

21 January 2018

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Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

21 January 2018

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PPARalpha in atherosclerosis and inflammation

21 January 2018

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PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

21 January 2018

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PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells

21 January 2018

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Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells

21 January 2018

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Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity

21 January 2018

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Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.

21 January 2018

1 reference

Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria

21 January 2018

1 reference

Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial

21 January 2018

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Are studies on severe malaria still possible?

21 January 2018

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

21 January 2018

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Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor

21 January 2018

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Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability.

21 January 2018

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Neuroprotection by erythropoietin administration after experimental traumatic brain injury

21 January 2018

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Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis

21 January 2018

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Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury

21 January 2018

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In vivo evidence that erythropoietin protects neurons from ischemic damage

21 January 2018

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Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria

21 January 2018

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Artesunate-erythropoietin combination for murine cerebral malaria treatment.

21 January 2018

1 reference

Recombinant human erythropoietin increases survival and reduces neuronal apoptosis in a murine model of cerebral malaria

21 January 2018

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Recombinant human erythropoietin prevents the death of mice during cerebral malaria

21 January 2018

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Recombinant human erythropoietin in the treatment of acute ischemic stroke

21 January 2018

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Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system

21 January 2018

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Erythropoietin as an antiapoptotic, tissue-protective cytokine.

21 January 2018

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Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF.

21 January 2018

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Levamisole inhibits sequestration of infected red blood cells in patients with falciparum malaria

21 January 2018

1 reference

CD36 and malaria: friends or foes?

21 January 2018

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CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium

21 January 2018

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Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria

21 January 2018

1 reference

The effect of curdlan sulphate on development in vitro of Plasmodium falciparum.

21 January 2018

1 reference

Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition

21 January 2018

1 reference

Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment.

21 January 2018

1 reference

Pharmacokinetics of L-arginine in adults with moderately severe malaria

21 January 2018

1 reference

Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali

21 January 2018

1 reference

Bridging the gap by AAA ATPases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERI.11.96

1 reference

25 August 2017

1 reference

PubMed ID

21905788