Advanced glycation end products and diabetic retinopathy (Q37930514)

25 August 2017

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title

Advanced glycation end products and diabetic retinopathy (English)

1 reference

advanced glycation end-product

25 August 2017

1 reference

ChEBI release 2020-05-28

Ross Milne

1

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PubMed ID

21909978

25 August 2017

Seymour Brownstein

series ordinal

2

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25 August 2017

11 September 2011

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25 August 2017

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25 August 2017

44

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25 August 2017

6

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25 August 2017

1397-1407

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https://scigraph.springernature.com/pub.10.1007/s00726-011-1071-3

25 August 2017

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cites work

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Advanced glycation endproducts: what is their relevance to diabetic complications?

21 January 2018

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Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins

21 January 2018

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A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy

21 January 2018

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Pericytes: cell biology and pathology

21 January 2018

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An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes

21 January 2018

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Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group

21 January 2018

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Endothelial/pericyte interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The RAGE axis in early diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

RAGE and its ligands in retinal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The role of pericytes in blood-vessel formation and maintenance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Chronic diabetes increases advanced glycation end products on cardiac ryanodine receptors/calcium-release channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Müller cells in the healthy and diseased retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The pathobiology of diabetic complications: a unifying mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Correlation of different circulating endothelial progenitor cells to stages of diabetic retinopathy: first in vivo data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Early breakdown of the blood-retinal barrier in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Pharmacological approach to diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Methylglyoxal downregulates Raf-1 protein through a ubiquitination-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Increased serum levels of the specific advanced glycation end product methylglyoxal-derived hydroimidazolone are associated with retinopathy in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complicat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Clinical review: The role of advanced glycation end products in progression and complications of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Differential accumulation of advanced glycation end products in the course of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Pericytes and the pathogenesis of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Diabetic retinopathy: targeting vasoregression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Signaling vascular morphogenesis and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The mechanism by which dietary AGEs are a risk to human health is via their interaction with RAGE: arguing against the motion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Diabetes and advanced glycoxidation end products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Role of lipids in chemical modification of proteins and development of complications in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Vascular plasticity--the role of the angiopoietins in modulating ocular angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Suppression of diabetic retinopathy with angiopoietin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Advanced glycation end products increase retinal vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor-induced ICAM-1 expression: inhibitory effect of antioxidants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Glyoxalase I deficiency is associated with an unusual level of advanced glycation end products in a hemodialysis patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Emerging drugs for diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT S

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Angiopoietin modulation of vascular endothelial growth factor: Effects on retinal endothelial cell permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Arguing for the motion: yes, RAGE is a receptor for advanced glycation endproducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

In situ observation of living pericytes in rat retinal capillaries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Dietary advanced glycation endproducts (AGEs) and their health effects--PRO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The effect of angiostatin on vascular leakage and VEGF expression in rat retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Advanced glycation end-products: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The role of advanced glycation in the pathogenesis of diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Effects of intensive glucose lowering in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

The glyoxalase system in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Regulation of vascular endothelial growth factor expression by advanced glycation end products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Protein glycation, diabetes, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Therapeutic potential of breakers of advanced glycation end product–protein crosslinks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Breakers of advanced glycation end products restore large artery properties in experimental diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Receptor-mediated toxicity to pericytes of advanced glycosylation end products: a possible mechanism of pericyte loss in diabetic microangiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

Toxic action of advanced glycation end products on cultured retinal capillary pericytes and endothelial cells: relevance to diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-1071-3

10.1007/S00726-011-1071-3

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21909978