Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways (Q37934996)

25 August 2017

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title

Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways (English)

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25 August 2017

Neil A Turner

1

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publication date

1 September 2011

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25 August 2017

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25 August 2017

volume

7

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25 August 2017

issue

5

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25 August 2017

page(s)

673-691

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Post-infarct remodelling: contribution of wound healing and inflammation

25 August 2017

cites work

1 reference

The immune system and cardiac repair.

21 January 2018

1 reference

The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction

21 January 2018

1 reference

ECM remodeling in hypertensive heart disease

21 January 2018

1 reference

Extracellular matrix remodeling during the progression of volume overload-induced heart failure

21 January 2018

1 reference

Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?

21 January 2018

1 reference

Cardiac fibroblasts: at the heart of myocardial remodeling

21 January 2018

1 reference

Cardiac fibroblast: the renaissance cell

21 January 2018

1 reference

Myocardial remodeling after infarction: the role of myofibroblasts

21 January 2018

1 reference

The origin of fibroblasts and mechanism of cardiac fibrosis

21 January 2018

1 reference

Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale

21 January 2018

1 reference

The complexity of mitogen-activated protein kinases (MAPKs) made simple

21 January 2018

1 reference

Mitogen-activated protein kinases in heart development and diseases

21 January 2018

1 reference

Atypical mitogen-activated protein kinases: structure, regulation and functions

21 January 2018

1 reference

Mechanisms and functions of p38 MAPK signalling.

21 January 2018

1 reference

Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease

21 January 2018

1 reference

Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)

21 January 2018

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Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

21 January 2018

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Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

21 January 2018

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Differential activation of p38MAPK isoforms by MKK6 and MKK3.

21 January 2018

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Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

21 January 2018

1 reference

The JIP family of MAPK scaffold proteins.

21 January 2018

1 reference

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

21 January 2018

1 reference

JNK signaling in apoptosis

21 January 2018

1 reference

c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

21 January 2018

1 reference

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

21 January 2018

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Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells.

21 January 2018

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p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes

21 January 2018

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Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart

21 January 2018

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Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo

21 January 2018

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Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.

21 January 2018

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Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

21 January 2018

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The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

21 January 2018

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p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

21 January 2018

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Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury

21 January 2018

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Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart

21 January 2018

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Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies

21 January 2018

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p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

21 January 2018

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Targeting p38-MAPK in the ischaemic heart: kill or cure?

21 January 2018

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Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point

21 January 2018

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The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning

21 January 2018

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The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes

21 January 2018

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Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

21 January 2018

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Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms

21 January 2018

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The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

21 January 2018

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Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase

21 January 2018

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c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

21 January 2018

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Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

21 January 2018

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Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload

21 January 2018

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c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction

21 January 2018

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The selectivity of protein kinase inhibitors: a further update

21 January 2018

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BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

21 January 2018

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The as-yet unfulfilled promise of p38 MAPK inhibitors

21 January 2018

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Inhibition of p38 Mitogen-Activated Protein Kinase Reduces Inflammation After Coronary Vascular Injury in Humans

21 January 2018

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Small molecule JNK (c-Jun N-terminal kinase) inhibitors.

21 January 2018

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Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster

21 January 2018

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Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene

21 January 2018

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Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

21 January 2018

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Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

21 January 2018

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A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo

21 January 2018

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Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.

21 January 2018

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Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.

21 January 2018

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Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.

21 January 2018

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ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts

21 January 2018

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Stimulation of adenosine A(2B) receptors induces interleukin-6 secretion in cardiac fibroblasts via the PKC-delta-P38 signalling pathway.

21 January 2018

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Noncanonical cAMP pathway and p38 MAPK mediate beta2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts.

21 January 2018

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AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK.

21 January 2018

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Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression

21 January 2018

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Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction

21 January 2018

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Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to acute hypoxia.

21 January 2018

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Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogen-activated protein kinase in the heart.

21 January 2018

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Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats

21 January 2018

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IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation

21 January 2018

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Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts

21 January 2018

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ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

21 January 2018

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Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway

21 January 2018

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Effects of visfatin on proliferation and collagen synthesis in rat cardiac fibroblasts.

21 January 2018

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The gp130 ligand oncostatin M regulates tissue inhibitor of metalloproteinases-1 through ERK1/2 and p38 in human adult cardiac myocytes and in human adult cardiac fibroblasts: a possible role for the gp130/gp130 ligand system in the modulation of ex

21 January 2018

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Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases

21 January 2018

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Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts

21 January 2018

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p38 mitogen-activated protein kinase inhibition decreases TNFalpha secretion and protects against left ventricular remodeling in rats with myocardial ischemia

21 January 2018

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Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus

21 January 2018

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Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction

21 January 2018

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Cell survival signalling in heart derived myofibroblasts induced by preconditioning and bradykinin: the role of p38 MAP kinase

21 January 2018

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Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.

21 January 2018

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Effects of interleukin-18 on cardiac fibroblast function and gene expression

21 January 2018

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Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling

21 January 2018

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Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta

21 January 2018

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Matricellular proteins in the heart: possible role during stress and remodeling

21 January 2018

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ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts

21 January 2018

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Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression

21 January 2018

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The cardiac fibroblast: therapeutic target in myocardial remodeling and failure

21 January 2018

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Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis

21 January 2018

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Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis

21 January 2018

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Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

21 January 2018

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Periostin as a heterofunctional regulator of cardiac development and disease

21 January 2018

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Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes.

21 January 2018

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Effect of cell-based intercellular delivery of transcription factor GATA4 on ischemic cardiomyopathy.

21 January 2018

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Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium.

21 January 2018

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Intramyocardial transplantation of fibroblasts expressing vascular endothelial growth factor attenuates cardiac dysfunction.

21 January 2018

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The inflammatory mediator oncostatin M induces stromal derived factor-1 in human adult cardiac cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FCA.11.41

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25 August 2017

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