Forming functional fat: a growing understanding of adipocyte differentiation (Q37939532)

25 August 2017

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title

Forming functional fat: a growing understanding of adipocyte differentiation (English)

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25 August 2017

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Ana G Cristancho

1

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PubMed ID

21952300

25 August 2017

Mitchell A Lazar

series ordinal

2

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25 August 2017

28 September 2011

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Nature Reviews Molecular Cell Biology

25 August 2017

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25 August 2017

12

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25 August 2017

722-734

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25 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm3198

25 August 2017

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The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

31 March 2020

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31 March 2020

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The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis

31 March 2020

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The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism

31 March 2020

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Inhibition of adipogenesis by Wnt signaling

31 March 2020

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Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha

31 March 2020

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Wnt10b inhibits development of white and brown adipose tissues.

31 March 2020

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Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma

31 March 2020

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Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.

31 March 2020

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Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

31 March 2020

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A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

31 March 2020

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The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop

31 March 2020

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Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms.

31 March 2020

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Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes

31 March 2020

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Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes

31 March 2020

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Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation

31 March 2020

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Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure

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Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation

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Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity

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BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

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Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis

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Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone).

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Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes

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Schnurri-2 Controls BMP-Dependent Adipogenesis via Interaction with Smad Proteins

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

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Adipose tissue extracellular matrix: newly organized by adipocytes during differentiation

31 March 2020

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Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes

31 March 2020

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Changes in integrin expression during adipocyte differentiation

31 March 2020

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Matrix elasticity directs stem cell lineage specification

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Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation.

31 March 2020

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Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuli.

31 March 2020

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A pericellular collagenase directs the 3-dimensional development of white adipose tissue

31 March 2020

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Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling.

31 March 2020

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TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation

31 March 2020

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Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells

31 March 2020

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Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha

31 March 2020

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Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal

31 March 2020

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

31 March 2020

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Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation

31 March 2020

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Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes.

31 March 2020

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Matrix metalloproteinase inhibition impairs adipose tissue development in mice

31 March 2020

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Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity

31 March 2020

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MT1-MMP: a key regulator of cell migration in tissue

31 March 2020

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Genetic link between obesity and MMP14-dependent adipogenic collagen turnover

31 March 2020

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Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation

31 March 2020

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TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix

31 March 2020

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Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in mice does not affect adipogenesis or adipose tissue development

31 March 2020

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Blood vessel density in de novo formed adipose tissue is decreased upon overexpression of TIMP-1.

31 March 2020

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Transplantation of adipose tissue and stem cells: role in metabolism and disease

31 March 2020

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An established pre-adipose cell line and its differentiation in culture.

31 March 2020

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Adipose conversion of 3T3 cells depends on a serum factor

31 March 2020

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Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone

31 March 2020

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A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker

31 March 2020

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Mitotic clonal expansion: a synchronous process required for adipogenesis

31 March 2020

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Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts

31 March 2020

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Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

31 March 2020

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Geometric cues for directing the differentiation of mesenchymal stem cells

31 March 2020

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Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.

31 March 2020

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Role of YAP/TAZ in mechanotransduction

31 March 2020

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Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

31 March 2020

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Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.

31 March 2020

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Transcriptional control of preadipocyte determination by Zfp423.

31 March 2020

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The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning.

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells

31 March 2020

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Stem cells and TCF proteins: a role for beta-catenin--independent functions

31 March 2020

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New developments in adipogenesis

31 March 2020

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Adipocyte differentiation and leptin expression

31 March 2020

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Adipocyte differentiation from the inside out

31 March 2020

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Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins

31 March 2020

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Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis

31 March 2020

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Propagation of adipogenic signals through an epigenomic transition state.

31 March 2020

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Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.

31 March 2020

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PKA-dependent and independent cAMP signaling in 3T3-L1 fibroblasts differentiation

31 March 2020

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Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes

31 March 2020

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PPARγ: a circadian transcription factor in adipogenesis and osteogenesis

31 March 2020

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PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

31 March 2020

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Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

31 March 2020

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Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.

31 March 2020

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Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis

31 March 2020

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Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).

31 March 2020

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JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription

31 March 2020

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Transcriptional regulation of adipogenesis by KLF4

31 March 2020

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Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms

31 March 2020

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Phosphorylation of C/EBPbeta at a consensus extracellular signal-regulated kinase/glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes

31 March 2020

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Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis

31 March 2020

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DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression

31 March 2020

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Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex

31 March 2020

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Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5

31 March 2020

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Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene

31 March 2020

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Sequential gene promoter interactions of C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis

31 March 2020

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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

31 March 2020

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

31 March 2020

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Thiazolidinediones regulate adipose lineage dynamics

31 March 2020

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mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

31 March 2020

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Comparative epigenomic analysis of murine and human adipogenesis

31 March 2020

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Redundant control of adipogenesis by histone deacetylases 1 and 2

31 March 2020

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Regulation of adipocyte differentiation by histone deacetylase inhibitors

31 March 2020

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Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis

31 March 2020

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Histone deacetylase 9 is a negative regulator of adipogenic differentiation

31 March 2020

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Down-regulation of histone deacetylases stimulates adipocyte differentiation

31 March 2020

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HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

31 March 2020

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

31 March 2020

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SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

31 March 2020

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Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis

31 March 2020

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Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis

31 March 2020

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Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}

31 March 2020

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Bifunctional role of Rev-erbalpha in adipocyte differentiation

31 March 2020

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A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation.

31 March 2020

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Function of GATA transcription factors in preadipocyte-adipocyte transition

31 March 2020

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TLE3 is a dual-function transcriptional coregulator of adipogenesis

31 March 2020

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Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

31 March 2020

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Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype

31 March 2020

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Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes

31 March 2020

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Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse

31 March 2020

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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

31 March 2020

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Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites

31 March 2020

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Species-specific strategies underlying conserved functions of metabolic transcription factors

31 March 2020

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PPARgamma in the control of brown adipocyte differentiation.

31 March 2020

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Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex

31 March 2020

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Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

31 March 2020

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

31 March 2020

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Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

31 March 2020

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Fat and beyond: the diverse biology of PPARgamma

31 March 2020

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Inhibitors of HDACs--effective drugs against cancer?

31 March 2020

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Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells

31 March 2020

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Inducible gene targeting in mice using the Cre/lox system

31 March 2020

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In vivo activation of cAMP-dependent protein kinase by aminophylline and 1-methyl, 3-isobutylxanthine

31 March 2020

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Human SGBS cells - a unique tool for studies of human fat cell biology

31 March 2020

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Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes

31 March 2020

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Transcriptional regulation of gene expression during adipocyte differentiation

31 March 2020

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A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo

31 March 2020

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Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes

31 March 2020

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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

31 March 2020

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Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development.

31 March 2020

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Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research

31 March 2020

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Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression

31 March 2020

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Rb regulates fate choice and lineage commitment in vivo

31 March 2020

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Enhanced synthesis and secretion of type IV collagen and entactin during adipose conversion of 3T3-L1 cells and production of unorthodox laminin complex.

31 March 2020

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12 December 2020

Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation

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12 December 2020

Increased cellular proliferation in adipose tissue of adult rats fed a high-fat diet

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12 December 2020

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation

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12 December 2020

Differentiation of 3T3-L1 fibroblasts to adipocytes. Effect of insulin and indomethacin on the levels of insulin receptors

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12 December 2020

Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes

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12 December 2020

Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice.

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12 December 2020

Regulation of adipogenesis by nuclear receptor PPARγ is modulated by the histone demethylase JMJD2C.

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12 December 2020

Diet-induced adipocyte number increase in adult rats: a new model of obesity

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12 December 2020

Cellularity of rat adipose tissue: effects of growth, starvation, and obesity

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12 December 2020

Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone.

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12 December 2020

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

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12 December 2020

Identifiers

DOI

10.1038/NRM3198

1 reference

PubMed ID

21952300

Dimensions Publication ID

25 August 2017

0 references

1 reference

PubMed ID

21952300