Toll-like receptors and diabetes: a therapeutic perspective (Q37954396)

25 August 2017

title

Toll-like receptors and diabetes: a therapeutic perspective (English)

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25 August 2017

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Mohan R Dasu

1

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25 August 2017

Sandra Ramirez

series ordinal

2

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25 August 2017

Roslyn R Isseroff

series ordinal

3

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25 August 2017

language of work or name

English

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publication date

1 March 2012

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25 August 2017

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25 August 2017

volume

122

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25 August 2017

issue

5

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25 August 2017

page(s)

203-214

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National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

25 August 2017

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Hyaluronan fragments stimulate endothelial recognition of injury through TLR4.

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The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

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Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects

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Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects

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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

21 January 2018

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Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

21 January 2018

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TLR4 links innate immunity and fatty acid-induced insulin resistance

21 January 2018

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High glucose induces toll-like receptor expression in human monocytes: mechanism of activation

21 January 2018

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Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation

21 January 2018

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Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications

21 January 2018

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Chemogenomics with peptide secondary structure mimetics

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Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs

21 January 2018

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Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

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Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

21 January 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells

21 January 2018

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Protein kinase C activation and the development of diabetic complications

21 January 2018

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Diabetes and atherosclerosis: is there a role for hyperglycemia?

21 January 2018

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TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase

21 January 2018

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Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.

21 January 2018

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Regulation of dendritic cell function through Toll-like receptors

21 January 2018

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TGF-alpha regulates TLR expression and function on epidermal keratinocytes

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Human adipose cells as candidates in defense and tissue remodeling phenomena

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Presence of functional TLR2 and TLR4 on human adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Lipid metabolism in human skeletal muscle cells: effects of palmitate and chronic hyperglycaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Tlr2 is critical for diet-induced metabolic syndrome in a murine model.

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

21 January 2018

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Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

21 January 2018

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Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study

21 January 2018

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Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation

21 January 2018

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A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet.

21 January 2018

1 reference

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Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3

21 January 2018

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Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Role of interleukin-1beta in the pathogenesis of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Cooperation of Toll-like receptor signals in innate immune defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Toll-like receptors and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

High glucose induces IL-1beta expression in human monocytes: mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Oxidative Stress and Diabetic Complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Linking oxidative stress to inflammation: Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Association of Toll-like receptor signaling and reactive oxygen species: a potential therapeutic target for posttrauma acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Diabetes is a proinflammatory state: a translational perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Toll-like receptors as targets for immune disorders

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Targeting Toll-like receptors: emerging therapeutics?

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Simvastatin treatment is associated with improvement in coronary endothelial function and decreased cytokine activation in patients after heart transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Emerging roles of PPARs in inflammation and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator–Activated Receptor-γ Agonist in Hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

PPARgamma agonist, rosiglitazone, regulates angiotensin II-induced vascular inflammation through the TLR4-dependent signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Central role of the AT(1)-receptor in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Inflammation and angiotensin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Angiotensin-converting enzyme and vascular remodeling

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Angiotensin receptor blockade in diabetic renal disease--focus on candesartan

21 January 2018

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Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Candesartan inhibits carotid intimal thickening and ameliorates insulin resistance in balloon-injured diabetic rats

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Vascular and metabolic effects of candesartan: insights from therapeutic interventions.

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Candesartan Reduces Oxidative Stress and Inflammation in Patients with Essential Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Anti-inflammatory and metabolic effects of candesartan in hypertensive patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Decoding the patterns of self and nonself by the innate immune system

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

21 January 2018

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https://api.crossref.org/works/10.1042%2FCS20110357

Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Anti-allergic activity of naringenin chalcone from a tomato skin extract

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Immunomodulation by polyunsaturated fatty acids: mechanisms and effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Folic acid says NO to vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Adding fuel to fire: microRNAs as a new class of mediators of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

MicroRNAs: the fine-tuners of Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Involvement of PKCα/β in TLR4 and TLR2 dependent activation of NF-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

Local Overexpression of Toll-Like Receptors at the Vessel Wall Induces Atherosclerotic Lesion Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20110357

21 January 2018

Identifiers

DOI

10.1042/CS20110357

1 reference

25 August 2017

1 reference