Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control (Q37959726)

25 August 2017

title

Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control (English)

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25 August 2017

1

Jeannie T Lee

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25 August 2017

publication date

23 November 2011

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Nature Reviews Molecular Cell Biology

25 August 2017

published in

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25 August 2017

volume

12

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25 August 2017

issue

12

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25 August 2017

page(s)

815-826

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Gene action in the X-chromosome of the mouse (Mus musculus L.)

25 August 2017

cites work

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X chromosome dosage compensation: how mammals keep the balance

21 January 2018

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Chromatin remodeling in dosage compensation

21 January 2018

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Vive la différence: males vs females in flies vs worms

21 January 2018

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A new model for random X chromosome inactivation

21 January 2018

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Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation

21 January 2018

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Mammalian X-chromosome inactivation

21 January 2018

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Dosage compensation in mammals: fine-tuning the expression of the X chromosome

21 January 2018

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21 January 2018

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Nettie M. Stevens and the Discovery of Sex Determination by Chromosomes

21 January 2018

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Some Genetic Aspects of Sex

21 January 2018

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Genetic Control of Biochemical Reactions in Neurospora

21 January 2018

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A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis

21 January 2018

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Formation of the sex chromatin by a single X-chromosome in liver cells of Rattus norvegicus

21 January 2018

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X-chromosome inactivation and developmental patterns in mammals

21 January 2018

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The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker

21 January 2018

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Mammalian X chromosome inactivation: testing the hypothesis of transcriptional control.

21 January 2018

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X Inactivation in Females with X-Linked Disease

21 January 2018

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Biology of the X chromosome

21 January 2018

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Glucose-6-Phosphate Dehydrogenase Mosaicism: Utilization as a Cell Marker in the Study of Leiomyomas

21 January 2018

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X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells

21 January 2018

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Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse

21 January 2018

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Parental imprinting of the mouse H19 gene

21 January 2018

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Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome.

21 January 2018

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Completion of mouse embryogenesis requires both the maternal and paternal genomes

21 January 2018

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Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

21 January 2018

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The role of X-chromosome inactivation during spermatogenesis (Drosophila-allocycly-chromosome evolution-male sterility-dosage compensation).

21 January 2018

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The X and Y chromosomes assemble into H2A.Z-containing [corrected] facultative heterochromatin [corrected] following meiosis.

21 January 2018

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Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids.

21 January 2018

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Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation

21 January 2018

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Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos.

21 January 2018

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Directed Genetic Change Model for X Chromosome Inactivation in Eutherian Mammals

21 January 2018

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HGPRT activity changes in preimplantation mouse embryos

21 January 2018

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Expression of alpha-galactosidase in preimplantation mouse embryos

21 January 2018

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Two-step imprinted X inactivation: repeat versus genic silencing in the mouse

21 January 2018

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Epigenetic dynamics of imprinted X inactivation during early mouse development

21 January 2018

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Reactivation of the paternal X chromosome in early mouse embryos

21 January 2018

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Establishment in culture of pluripotential cells from mouse embryos

21 January 2018

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Altering the genome by homologous recombination

21 January 2018

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X chromosome reactivation initiates in nascent primordial germ cells in mice

21 January 2018

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Early loss of Xist RNA expression and inactive X chromosome associated chromatin modification in developing primordial germ cells.

21 January 2018

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X chromosome activity in mouse XX primordial germ cells

21 January 2018

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Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine

21 January 2018

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X inactivation, differentiation, and DNA methylation

21 January 2018

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Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development

21 January 2018

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Regulation of X-chromosome counting by Tsix and Xite sequences

21 January 2018

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Targeted mutagenesis of Tsix leads to nonrandom X inactivation.

21 January 2018

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Localization of the X inactivation centre on the human X chromosome in Xq13.

21 January 2018

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Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies

21 January 2018

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A 450 kb transgene displays properties of the mammalian X-inactivation center.

21 January 2018

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Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain

21 January 2018

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A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

21 January 2018

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Characterization of a murine gene expressed from the inactive X chromosome

21 January 2018

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Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.

21 January 2018

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The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

21 January 2018

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The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

21 January 2018

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XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure

21 January 2018

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Requirement for Xist in X chromosome inactivation

21 January 2018

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Chromosomal silencing and localization are mediated by different domains of Xist RNA.

21 January 2018

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The product of the H19 gene may function as an RNA

21 January 2018

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Igf2 imprinting does not require its own DNA methylation or H19 RNA.

21 January 2018

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Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes

21 January 2018

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Role of histone H3 lysine 27 methylation in X inactivation

21 January 2018

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A chromosomal memory triggered by Xist regulates histone methylation in X inactivation

21 January 2018

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Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells

21 January 2018

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Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

21 January 2018

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2-D structure of the A region of Xist RNA and its implication for PRC2 association

21 January 2018

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

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Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

21 January 2018

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YY1 tethers Xist RNA to the inactive X nucleation center

21 January 2018

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Tsix, a gene antisense to Xist at the X-inactivation centre

21 January 2018

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Disruption of imprinted X inactivation by parent-of-origin effects at Tsix.

21 January 2018

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The DXPas34 repeat regulates random and imprinted X inactivation

21 January 2018

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Intersection of the RNA interference and X-inactivation pathways

21 January 2018

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Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice.

21 January 2018

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A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice

21 January 2018

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Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells

21 January 2018

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Role of the region 3' to Xist exon 6 in the counting process of X-chromosome inactivation

21 January 2018

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The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene

21 January 2018

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An essential role for the DXPas34 tandem repeat and Tsix transcription in the counting process of X chromosome inactivation

21 January 2018

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Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.

21 January 2018

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Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.

21 January 2018

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Tsix silences Xist through modification of chromatin structure

21 January 2018

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Tsix defective in splicing is competent to establish Xist silencing.

21 January 2018

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Effect of TSIX disruption on XIST expression in male ES cells.

21 January 2018

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Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein.

21 January 2018

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Transient homologous chromosome pairing marks the onset of X inactivation

21 January 2018

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A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization

21 January 2018

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Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation

21 January 2018

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Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a

21 January 2018

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X chromosome inactivation in the absence of Dicer.

21 January 2018

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Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: implications for X inactivation

21 January 2018

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Is Tsix repression of Xist specific to mouse?

21 January 2018

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Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation

21 January 2018

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Xite, X-inactivation intergenic transcription elements that regulate the probability of choice

21 January 2018

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A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.

21 January 2018

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Characterization of expression at the human XIST locus in somatic, embryonal carcinoma, and transgenic cell lines

21 January 2018

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The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation

21 January 2018

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RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation

21 January 2018

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RNF12 activates Xist and is essential for X chromosome inactivation

21 January 2018

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Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice

21 January 2018

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A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx.

21 January 2018

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The mouse Tsx gene is expressed in Sertoli cells of the adult testis and transiently in premeiotic germ cells during puberty

21 January 2018

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Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain

21 January 2018

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Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

21 January 2018

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Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist

21 January 2018

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The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

21 January 2018

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Molecular coupling of Tsix regulation and pluripotency

21 January 2018

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Molecular coupling of Xist regulation and pluripotency.

21 January 2018

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Chromatin structure of active and inactive human X chromosomes

21 January 2018

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Comparison of transformation efficiency of human active and inactive X-chromosomal DNA.

21 January 2018

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The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences

21 January 2018

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A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

21 January 2018

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Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome

21 January 2018

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The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.

21 January 2018

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The Lyon and the LINE hypothesis

21 January 2018

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Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis

21 January 2018

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Evidence of influence of genomic DNA sequence on human X chromosome inactivation

21 January 2018

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LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation

21 January 2018

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X chromosome inactivation and Xist evolution in a rodent lacking LINE-1 activity

21 January 2018

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Silencing of the mammalian X chromosome

21 January 2018

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The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation

21 January 2018

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The matrix protein hnRNP U is required for chromosomal localization of Xist RNA.

21 January 2018

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Scaffold attachment factor A (SAF-A) is concentrated in inactive X chromosome territories through its RGG domain

21 January 2018

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SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells

21 January 2018

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Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing.

21 January 2018

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Escape from X inactivation in mice and humans

21 January 2018

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A first-generation X-inactivation profile of the human X chromosome

21 January 2018

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X-inactivation profile reveals extensive variability in X-linked gene expression in females

21 January 2018

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Genes that escape from X inactivation

21 January 2018

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Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development

21 January 2018

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Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus

21 January 2018

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Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation.

21 January 2018

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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

21 January 2018

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Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic.

21 January 2018

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Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression

21 January 2018

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Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation

21 January 2018

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Symmetry-breaking model for X-chromosome inactivation.

21 January 2018

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Genome-wide transcription and the implications for genomic organization

21 January 2018

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Evolution and functions of long noncoding RNAs

21 January 2018

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The transcriptional landscape of the mammalian genome

21 January 2018

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The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene

21 January 2018

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Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome

21 January 2018

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The X as model for RNA's niche in epigenomic regulation

21 January 2018

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Genome-wide identification of polycomb-associated RNAs by RIP-seq

21 January 2018

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Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

21 January 2018

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No-nonsense functions for long noncoding RNAs

21 January 2018

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Long noncoding RNA in genome regulation: prospects and mechanisms

21 January 2018

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Long noncoding RNAs with enhancer-like function in human cells

21 January 2018

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

21 January 2018

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X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

21 January 2018

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X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected

21 January 2018

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In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes

21 January 2018

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Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development.

21 January 2018

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Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice

21 January 2018

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SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation

21 January 2018

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The evolution of chromosomal sex determination and dosage compensation

21 January 2018

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Sex chromosome specialization and degeneration in mammals

21 January 2018

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Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes

21 January 2018

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Dosage compensation of the active X chromosome in mammals

21 January 2018

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RNA sequencing shows no dosage compensation of the active X-chromosome

21 January 2018

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X-chromosome kiss and tell: how the Xs go their separate ways.

21 January 2018

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Late DNA Replication in the Paternally Derived X Chromosome of Female Kangaroos

21 January 2018

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Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

21 January 2018

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X–chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro

21 January 2018

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Possible mechanisms of X chromosome inactivation.

21 January 2018

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Postmeiotic sex chromatin in the male germline of mice

31 March 2020

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Dosage compensation for an X-linked gene in pre-implantation mouse embryos

31 March 2020

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Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation

31 March 2020

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Evidence for two functional X chromosomes in human oocytes

31 March 2020

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5-Azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line

31 March 2020

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Evidence of non-random X chromosome activity in the mouse

31 March 2020

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Human X inactivation center induces random X chromosome inactivation in male transgenic mice

31 March 2020

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Molecular correlates of the murine Xce locus

31 March 2020

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Xist-deficient mice are defective in dosage compensation but not spermatogenesis

31 March 2020

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Imprinted X inactivation maintained by a mouse Polycomb group gene

31 March 2020

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Enox, a novel gene that maps 10 kb upstream of Xist and partially escapes X inactivation

31 March 2020

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Homologous association of oppositely imprinted chromosomal domains

31 March 2020

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X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

31 March 2020

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More about the mammalian X chromosome

31 March 2020

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X-chromosome inactivation mosaicism in the three germ layers and the germ line of the mouse embryo

31 March 2020

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12 December 2020

X inactivation in females with X-linked disease.

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12 December 2020

Variegated-type position effects in the mouse.

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12 December 2020

Random X-chromosome inactivation in female primordial germ cells in the mouse

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12 December 2020

Regulation of X-chromosome inactivation in development in mice and humans

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12 December 2020

Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine

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12 December 2020

Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth

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12 December 2020

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

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12 December 2020

Controlling elements in the mouse X chromosome

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12 December 2020

Regulation of imprinted X-chromosome inactivation in mice by Tsix.

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12 December 2020

Sex chromatin and the sex chromosomes: on the origin of sex chromatin from a single X chromosome

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12 December 2020

Imprinting and X-chromosome inactivation.

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12 December 2020

Phosphoribosyltransferase Activity during Early Mammalian Development

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12 December 2020

X-chromosome activity in foetal germ cells of the mouse

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12 December 2020

X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation

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12 December 2020

Identifiers

DOI

10.1038/NRM3231

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25 August 2017

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