The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome (Q37968125)

26 August 2017

title

The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome (English)

1 reference

26 August 2017

0 references

Jodene Eldstrom

1

1 reference

26 August 2017

David Fedida

series ordinal

2

1 reference

26 August 2017

publication date

14 December 2011

1 reference

Expert Reviews in Molecular Medicine

26 August 2017

published in

1 reference

26 August 2017

volume

13

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26 August 2017

page(s)

e38

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Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

26 August 2017

cites work

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Intracellular domains interactions and gated motions of I(KS) potassium channel subunits

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KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel

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KCNE1 constrains the voltage sensor of Kv7.1 K+ channels

21 January 2018

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KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains

21 January 2018

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Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines

21 January 2018

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KCNQ1 mutations in patients with a family history of lethal cardiac arrhythmias and sudden death

21 January 2018

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KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity

21 January 2018

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Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡

21 January 2018

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KCNQ1/KCNE1 assembly, co-translation not required

21 January 2018

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KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression

21 January 2018

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

21 January 2018

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

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Ancillary subunits associated with voltage-dependent K+ channels

21 January 2018

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KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.

21 January 2018

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Arrhythmic risk in congenital long QT syndrome

21 January 2018

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Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis

21 January 2018

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Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

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KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels

21 January 2018

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Molecular and cellular mechanisms of cardiac arrhythmias

21 January 2018

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Amiodarone-associated macroscopic T-wave alternans and torsade de pointes unmasking the inherited long QT syndrome

21 January 2018

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Novel gene hKCNE4 slows the activation of the KCNQ1 channel

21 January 2018

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Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome

21 January 2018

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In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart

21 January 2018

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KCNE4 is an inhibitory subunit to the KCNQ1 channel

21 January 2018

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A constitutively open potassium channel formed by KCNQ1 and KCNE3

21 January 2018

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Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the cystic fibrosis transmembrane conductance regulator

21 January 2018

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Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation

21 January 2018

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Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).

21 January 2018

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Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?

21 January 2018

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Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle

21 January 2018

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Role of heteromultimers in the generation of myocardial transient outward K+ currents.

21 January 2018

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Modulation of A-type potassium channels by a family of calcium sensors

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

21 January 2018

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Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome

21 January 2018

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Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis

21 January 2018

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A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

21 January 2018

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Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.

21 January 2018

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Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

21 January 2018

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21 January 2018

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21 January 2018

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Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium

21 January 2018

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Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current

21 January 2018

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Expression and coassociation of ERG1, KCNQ1, and KCNE1 potassium channel proteins in horse heart

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Anti-minK Antisense Decreases the Amplitude of the Rapidly Activating Cardiac Delayed Rectifier K + Current

21 January 2018

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21 January 2018

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Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

21 January 2018

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A minK-HERG complex regulates the cardiac potassium current I(Kr)

21 January 2018

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Differential association between HERG and KCNE1 or KCNE2

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium.

21 January 2018

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A common polymorphism associated with antibiotic-induced cardiac arrhythmia

21 January 2018

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KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs.

21 January 2018

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Cloning of a membrane protein that induces a slow voltage-gated potassium current

21 January 2018

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Single nucleotide polymorphism map of five long-QT genes.

21 January 2018

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Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

21 January 2018

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Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

21 January 2018

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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

21 January 2018

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The role of the funny current in pacemaker activity.

21 January 2018

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Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

21 January 2018

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Cardiac ion channels in health and disease

21 January 2018

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Mutations in the hminK gene cause long QT syndrome and suppress IKs function

21 January 2018

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Molecular physiology of cardiac repolarization

21 January 2018

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SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

21 January 2018

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Screening for copy number variation in genes associated with the long QT syndrome: clinical relevance.

21 January 2018

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

21 January 2018

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Identification of a Kir3.4 mutation in congenital long QT syndrome

21 January 2018

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Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

21 January 2018

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Pharmacological and non-pharmacological management of the congenital long QT syndrome: the rationale

21 January 2018

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Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

21 January 2018

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Novel insights in the congenital long QT syndrome

21 January 2018

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Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

21 January 2018

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SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome

21 January 2018

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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

21 January 2018

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Cardiac arrhythmia and thyroid dysfunction: a novel genetic link

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice.

21 January 2018

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Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Cardiomyopathic and channelopathic causes of sudden unexplained death in infants and children

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Compound mutations: a common cause of severe long-QT syndrome

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

An intronic mutation causes long QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome

21 January 2018

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Prevalence and spectrum of large deletions or duplications in the major long QT syndrome-susceptibility genes and implications for long QT syndrome genetic testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Gene expression profiling of human cardiac potassium and sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Hyperpolarization-activated cation channels: from genes to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Two pacemaker channels from human heart with profoundly different activation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

The anatomy and physiology of the sinoatrial node--a contemporary review

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Proteomic analysis highlights the molecular complexities of native Kv4 channel macromolecular complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f)

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Prolongation of the QT interval and the sudden infant death syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Prevalence of the congenital long-QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

QTc: how long is too long?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Drug- and non-drug-associated QT interval prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1).

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399411002092

Risk stratification in the long-QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Modulation of Kv4.3 current by accessory subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Kvbeta subunits increase expression of Kv4.3 channels by interacting with their C termini

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

A KCNH2 branch point mutation causing aberrant splicing contributes to an explanation of genotype-negative long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium versus midmyocardium

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Modulation of functional properties of KCNQ1 channel by association of KCNE1 and KCNE2

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Antisense oligodeoxynucleotides directed against Kv1.5 mRNA specifically inhibit ultrarapid delayed rectifier K+ current in cultured adult human atrial myocytes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Xenopus oocytes injected with rat uterine RNA express very slowly activating potassium currents

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411002092

7 January 2021

10.1017/S1462399411002092

Identifiers

DOI

1 reference

26 August 2017

1 reference