Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker. (Q37968528)

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18 January 2020

title

Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker (English)

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18 January 2020

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3

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18 January 2020

author name string

Zhonglin Hao

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Hui Zhang

series ordinal

2

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18 January 2020

language of work or name

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16 December 2011

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18 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

33

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18 January 2020

issue

3

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18 January 2020

page(s)

723-730

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https://scigraph.springernature.com/pub.10.1007/s13277-011-0291-1

18 January 2020

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cites work

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Validation of UBE2C protein as a prognostic marker in node-positive breast cancer

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The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

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Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma

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Basic mechanism of eukaryotic chromosome segregation

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How do so few control so many?

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EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes

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Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.

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Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10

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Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

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Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubule-targeted drugs in killing human cancer cells

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Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10

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UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.

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UbcH10 expression on thyroid fine-needle aspirates.

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Hallmarks of Cancer: The Next Generation

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CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability

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DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables

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Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

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Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

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Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma.

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12 December 2020

The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

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12 December 2020

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

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12 December 2020

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

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The influence of resection and aneuploidy on mortality in oral leukoplakia

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Regulatory mechanisms involved in the control of ubiquitin homeostasis

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Identification and validation of genes involved in cervical tumourigenesis

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Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

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Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

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Severity of carpal tunnel syndrome assessed with high frequency ultrasonography

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UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas

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c-Myc: linking transformation and genomic instability

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UbcH10 expression in human lymphomas.

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12 December 2020

Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution

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12 December 2020

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

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12 December 2020

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

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12 December 2020

Ubiquitin-binding domains

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12 December 2020

Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.

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12 December 2020

Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma

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12 December 2020

Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.

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12 December 2020

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

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12 December 2020

UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas

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12 December 2020

Prediction of metastatic relapse in node-positive breast cancer: establishment of a clinicogenomic model after FEC100 adjuvant regimen

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12 December 2020

Association of clinicopathological features with UbcH10 expression in colorectal cancer

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12 December 2020

Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas

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12 December 2020

Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors

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12 December 2020

Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth

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12 December 2020

All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo

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12 December 2020

Divergent routes to oral cancer

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12 December 2020

Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma.

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12 December 2020

Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer

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12 December 2020

UbcH10 is overexpressed in malignant breast carcinomas

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12 December 2020

Mutual regulation between the spindle checkpoint and APC/C.

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12 December 2020

Ubiquitin ligases and the immune response

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12 December 2020

Recycling the cell cycle: cyclins revisited

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12 December 2020

RETRACTED ARTICLE. Painful os intermetatarseum in athletes: a literature review of this condition is presented

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1007/S12178-010-9062-7

Identifiers

DOI

10.1007/S13277-011-0291-1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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