The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma (Q37969932)

26 August 2017

title

The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma (English)

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26 August 2017

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Nardin Samuel

1

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26 August 2017

Thomas J Hudson

series ordinal

2

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26 August 2017

language of work or name

English

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publication date

20 December 2011

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Nature Reviews Gastroenterology & Hepatology

26 August 2017

published in

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26 August 2017

volume

9

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26 August 2017

issue

2

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26 August 2017

page(s)

77-87

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

26 August 2017

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21 January 2018

Cancer statistics, 2010

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genetics and biology of pancreatic ductal adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Proteomics of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Stromal biology of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Stromal biology and therapy in pancreatic cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Pancreatic cancer: understanding and overcoming chemoresistance

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Development and characterization of gemcitabine-resistant pancreatic tumor cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Somatic variation and cancer: therapies lost in the mix.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

The molecular pathology of cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Signatures of mutation and selection in the cancer genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Pancreatic cancer biology and genetics

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Pancreatic intraductal sampling during ERCP in patients with chronic pancreatitis and pancreatic cancer: cytologic studies and k-ras-2 codon 12 molecular analysis in 47 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genetic progression in the pancreatic ducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Mucin gene and antigen expression in biliopancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Integrated genomic analyses of ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Linking somatic genetic alterations in cancer to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

International network of cancer genome projects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Expression profiling identifies microRNA signature in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Exploring the genomes of cancer cells: progress and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Molecular predictors of response to trastuzumab and lapatinib in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

An effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Identification of frequent chromosomal aberrations in ductal adenocarcinoma of the pancreas by comparative genomic hybridization (CGH).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

A comparison of DNA copy number changes detected by comparative genomic hybridization in malignancies of the liver, biliary tract and pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

High-resolution characterization of the pancreatic adenocarcinoma genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genome-wide aberrations in pancreatic adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genome-wide analysis of pancreatic cancer using microarray-based techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Molecular pathogenesis of pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Relative contribution of Ki-ras gene analysis and brush cytology during ERCP for the diagnosis of biliary and pancreatic diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Differential MUC 1 expression in normal and neoplastic human pancreatic tissue. An immunohistochemical study of 60 samples

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Comparative genomic hybridization analysis for pancreatic cancer specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

The prevalence of BRCA2 mutations in familial pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

31 March 2020

12 December 2020

Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Amplification of DNA sequences from chromosome 19q13.1 in human pancreatic cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Detection of genetic alterations in pancreatic cancers by comparative genomic hybridization coupled with tissue microdissection and degenerate oligonucleotide primed polymerase chain reaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.215

Familial pancreatic cancer: a review.

31 March 2020

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12 December 2020

Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization

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12 December 2020

Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis

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12 December 2020

The genetic basis of sporadic pancreatic cancer.

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12 December 2020

Progression model for pancreatic cancer.

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12 December 2020

The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.

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12 December 2020

K-ras mutations in pancreatic ductal proliferative lesions

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12 December 2020

Tumor-suppressive pathways in pancreatic carcinoma.

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12 December 2020

Pancreatic adenocarcinomas frequently show p53 gene mutations.

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12 December 2020

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes

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12 December 2020

Molecular signatures of pancreatic cancer

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12 December 2020

Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene

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12 December 2020

Mapping of chromosomal imbalances in pancreatic carcinoma by comparative genomic hybridization

1 reference

12 December 2020

10.1038/NRGASTRO.2011.215

Identifiers

DOI

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26 August 2017

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